Parallelized Inference for Gravitational-Wave Astronomy

Bayesian inference is the workhorse of gravitational-wave astronomy, for example, determining the mass and spins of merging black holes, revealing the neutron star equation of state, and unveiling the population properties of compact binaries. The science enabled by these inferences comes with a computational cost that can limit the questions we are able to answer. This cost is expected to grow. As detectors improve, the detection rate will go up, allowing less time to analyze each event. Improvement in low-frequency sensitivity will yield longer signals, increasing the number of computations per event. The growing number of entries in the transient catalog will drive up the cost of population studies. While Bayesian inference calculations are not entirely parallelizable, key components are embarrassingly parallel: calculating the gravitational waveform and evaluating the likelihood function. Graphical processor units (GPUs) are adept at such parallel calculations. We report on progress porting gravitational-wave inference calculations to GPUs. Using a single code - which takes advantage of GPU architecture if it is available - we compare computation times using modern GPUs (NVIDIA P100) and CPUs (Intel Gold 6140). We demonstrate speed-ups of $\sim 50 \times$ for compact binary coalescence gravitational waveform generation and likelihood evaluation and more than $100\times$ for population inference within the lifetime of current detectors. Further improvement is likely with continued development. Our python-based code is publicly available and can be used without familiarity with the parallel computing platform, CUDA.Comment: 5 pages, 4 figures, submitted to PRD, code can be found at https://github.com/ColmTalbot/gwpopulation https://github.com/ColmTalbot/GPUCBC https://github.com/ADACS-Australia/ADACS-SS18A-RSmith Add demonstration of improvement in BNS spi

A model of large-scale proteome evolution

The next step in the understanding of the genome organization, after the determination of complete sequences, involves proteomics. The proteome includes the whole set of protein-protein interactions, and two recent independent studies have shown that its topology displays a number of surprising features shared by other complex networks, both natural and artificial. In order to understand the origins of this topology and its evolutionary implications, we present a simple model of proteome evolution that is able to reproduce many of the observed statistical regularities reported from the analysis of the yeast proteome. Our results suggest that the observed patterns can be explained by a process of gene duplication and diversification that would evolve proteome networks under a selection pressure, favoring robustness against failure of its individual components

First Records for \u3ci\u3eAeshna Sitchensis\u3c/i\u3e (Odonata: Aeshnidae) and \u3ci\u3eEnallagma Clausum\u3c/i\u3e (Odonata: Coenagrionidae), and a Northwestern Record for the State-Endangered \u3ci\u3eSomatochlora Incurvata\u3c/i\u3e (Odonata: Corduliidae) in Wisconsin

While surveying for Odonata in coastal peatlands and associated shoreline areas adjacent to Lake Superior in Wisconsin, we documented populations of two new state record species, the zig-zag darner (Aeshna sitchensis Hagen) and the alkali bluet (Enallagma clausum Morse). We also located a robust population of the state-endangered incurvate emerald (Somatochlora incurvata Walker) at the northwestern edge of the known range of this species. Adults and exuviae of A. sitchensis and S. incurvata were found at an insular fen on Stockton Island, Ashland County, within the Apostle Islands National Lakeshore (AINL). Breeding of both species had occurred in areas of the fen where small pools had dried by summer. Additionally, a single adult male A. sitchensis was collected in the City of Superior in Douglas County. Adult E. clausum were found at two sites: on the Lake Superior beach near the mouth of the Sand River within the AINL in Bayfield County, and along the northeast shore of Allouez Bay in the City of Superior in Douglas County

Detection of bondline delaminations in multilayer structures with lossy components

The detection of bondline delaminations in multilayer structures using ultrasonic reflection techniques is a generic problem in adhesively bonded composite structures such as the Space Shuttles's Solid Rocket Motors (SRM). Standard pulse echo ultrasonic techniques do not perform well for a composite resonator composed of a resonant layer combined with attenuating layers. Excessive ringing in the resonant layer tends to mask internal echoes emanating from the attenuating layers. The SRM is made up of a resonant steel layer backed by layers of adhesive, rubber, liner and fuel, which are ultrasonically attenuating. The structure's response is modeled as a lossy ultrasonic transmission line. The model predicts that the acoustic response of the system is sensitive to delaminations at the interior bondlines in a few narrow frequency bands. These predictions are verified by measurements on a fabricated system. Successful imaging of internal delaminations is sensitive to proper selection of the interrogating frequency. Images of fabricated bondline delaminations are presented based on these studies

Consumption-Based Conservation Targeting: Linking Biodiversity Loss to Upstream Demand through a Global Wildlife Footprint.

Although most conservation efforts address the direct, local causes of biodiversity loss, effective long-term conservation will require complementary efforts to reduce the upstream economic pressures, such as demands for food and forest products, which ultimately drive these downstream losses. Here, we present a wildlife footprint analysis that links global losses of wild birds to consumer purchases across 57 economic sectors in 129 regions. The United States, India, China, and Brazil have the largest regional wildlife footprints, while per-person footprints are highest in Mongolia, Australia, Botswana, and the United Arab Emirates. A US$100 purchase of bovine meat or rice products occupies approximately 0.1 km2 of wild bird ranges, displacing 1-2 individual birds, for 1 year. Globally significant importer regions, including Japan, the United Kingdom, Germany, Italy, and France, have large footprints that drive wildlife losses elsewhere in the world and represent important targets for consumption-focused conservation attention

The BTC40 Survey for Quasars at 4.8 < z < 6

The BTC40 Survey for high-redshift quasars is a multicolor search using images obtained with the Big Throughput Camera (BTC) on the CTIO 4-m telescope in V, I, and z filters to search for quasars at redshifts of 4.8 < z < 6. The survey covers 40 sq. deg. in B, V, & I and 36 sq. deg. in z. Limiting magnitudes (3 sigma) reach to V = 24.6, I = 22.9 and z = 22.9. We used the (V-I) vs. (I-z) two-color diagram to select high-redshift quasar candidates from the objects classified as point sources in the imaging data. Follow-up spectroscopy with the AAT and CTIO 4-m telescopes of candidates having I < 21.5 has yielded two quasars with redshifts of z = 4.6 and z = 4.8 as well as four emission line galaxies with z = 0.6. Fainter candidates have been identified down to I = 22 for future spectroscopy on 8-m class telescopes.Comment: 27 pages, 8 figures; Accepted for publication in the Astronomical Journa

Patterns, predictors, variations, and temporal trends in emergency medical service hospital prenotification for acute ischemic stroke.

BACKGROUND#ENTITYSTARTX02014;: Emergency medical services (EMS) hospital prenotification of an incoming stroke patient is guideline recommended as a means of increasing the timeliness with which stroke patients are evaluated and treated. Still, data are limited with regard to national use of, variations in, and temporal trends in EMS prenotification and associated predictors of its use. METHODS AND RESULTS#ENTITYSTARTX02014;: We examined 371 988 patients with acute ischemic stroke who were transported by EMS and enrolled in 1585 hospitals participating in Get With The Guidelines-Stroke from April 1, 2003, through March 31, 2011. Prenotification occurred in 249 197 EMS-transported patients (67.0%) and varied widely by hospital (range, 0% to 100%). Substantial variations by geographic regions and by state, ranging from 19.7% in Washington, DC, to 93.4% in Montana, also were noted. Patient factors associated with lower use of prenotification included older age, diabetes mellitus, and peripheral vascular disease. Prenotification was less likely for black patients than for white patients (adjusted odds ratio 0.94, 95% confidence interval 0.92-0.97, P&lt;0.0001). Hospital factors associated with greater EMS prenotification use were absence of academic affiliation, higher annual volume of tissue plasminogen activator administration, and geographic location outside the Northeast. Temporal improvements in prenotification rates showed a modest general increase, from 58.0% in 2003 to 67.3% in 2011 (P temporal trend &lt;0.0001). CONCLUSIONS#ENTITYSTARTX02014;: EMS hospital prenotification is guideline recommended, yet among patients transported to Get With The Guidelines-Stroke hospitals it is not provided for 1 in 3 EMS-arriving patients with acute ischemic stroke and varies substantially by hospital, state, and region. These results support the need for enhanced implementation of stroke systems of care. (J Am Heart Assoc. 2012;1:e002345 doi: 10.1161/JAHA.112.002345.)

Ambient air pollution and adverse birth outcomes: A review of underlying mechanisms

Epidemiological data provide varying degrees of evidence for associations between prenatal exposure to ambient air pollutants and adverse birth outcomes (suboptimal measures of fetal growth, preterm birth and stillbirth). To assess further certainty of effects, this review examines the experimental literature base to identify mechanisms by which air pollution (particulate matter, nitrogen dioxide and ozone) could cause adverse effects on the developing fetus. It likely that this environmental insult impacts multiple biological pathways important for sustaining a healthy pregnancy, depending upon the composition of the pollutant mixture and the exposure window owing to changes in physiologic maturity of the placenta, its circulations and the fetus as pregnancy ensues. The current body of evidence indicates that the placenta is a target tissue, impacted by a variety of critical processes including nitrosative/oxidative stress, inflammation, endocrine disruption, epigenetic changes, as well as vascular dysregulation of the maternal‐fetal unit. All of the above can disturb placental function and, as a consequence, could contribute to compromised fetal growth as well increasing the risk of stillbirth. Furthermore, given that there is often an increased inflammatory response associated with preterm labour, inflammation is a plausible mechanism mediating the effects of air pollution on premature delivery. In the light of increased urbanisation and an ever‐changing climate, both of which increase ambient air pollution and negatively affect vulnerable populations such as pregnant individuals, it is hoped that the collective evidence may contribute to decisions taken to strengthen air quality policies, reductions in exposure to air pollution and subsequent improvements in the health of those not yet born