Globular Clusters in the Sombrero Galaxy (NGC 4594)

The Sombrero galaxy, NGC 4594, contains the most numerous globular cluster system of any nearby spiral. It is an ideal candidate in which to study the globular clusters and contrast them with those in Local Group spirals. Here we present B and I imaging from the CTIO Schmidt telescope which gives a field-of-view of 31' x 31'. Using DAOPHOT we have detected over 400 globular clusters and derived their magnitudes, B--I colors and photometric metallicities. We have attempted to separate our sample into disk and bulge/halo globular cluster populations, based on location in the galaxy. There is some evidence that the disk population is more metal--rich than the bulge/halo globular clusters, however contamination, dust reddening and small number statistics makes this result very tentative. We find that the median metallicity of the bulge/halo globular clusters is [Fe/H] = -0.8. This metallicity is consistent with previous estimates based on smaller samples. It is also similar to the metallicity predicted by the globular cluster metallicity -- galaxy luminosity relation. As with our Galaxy, there is no radial metallicity gradient in the halo globular clusters. This suggests that the spheriodal component of NGC 4594 did not form by a dissipational process.Comment: 7 pages, Latex. To be published in the Astronomical Journal. Full paper available at http://www.ucolick.org/~forbes/home.htm

The Purple Haze of Eta Carinae: Binary-Induced Variability?

Asymmetric variability in ultraviolet images of the Homunculus obtained with the Advanced Camera for Surveys/High Resolution Camera on the Hubble Space Telescope suggests that Eta Carinae is indeed a binary system. Images obtained before, during, and after the recent ``spectroscopic event'' in 2003.5 show alternating patterns of bright spots and shadows on opposite sides of the star before and after the event, providing a strong geometric argument for an azimuthally-evolving, asymmetric UV radiation field as one might predict in some binary models. The simplest interpretation of these UV images, where excess UV escapes from the secondary star in the direction away from the primary, places the major axis of the eccentric orbit roughly perpendicular to our line of sight, sharing the same equatorial plane as the Homunculus, and with apastron for the hot secondary star oriented toward the southwest of the primary. However, other orbital orientations may be allowed with more complicated geometries. Selective UV illumination of the wind and ejecta may be partly responsible for line profile variations seen in spectra. The brightness asymmetries cannot be explained plausibly with delays due to light travel time alone, so a single-star model would require a seriously asymmetric shell ejection.Comment: 8 pages, fig 1 in color, accepted by ApJ Letter

Characterization of dengue virus entry into HepG2 cells

<p>Abstract</p> <p>Background</p> <p>Despite infections by the dengue virus being a significant problem in tropical and sub-tropical countries, the mechanism by which the dengue virus enters into mammalian cells remains poorly described.</p> <p>Methods</p> <p>A combination of biochemical inhibition, dominant negative transfection of Eps15 and siRNA mediated gene silencing was used to explore the entry mechanism of dengue into HepG2 cells.</p> <p>Results</p> <p>Results were consistent with entry via multiple pathways, specifically via clathrin coated pit mediated endocytosis and macropinocytosis, with clathrin mediated endocytosis being the predominant pathway.</p> <p>Conclusion</p> <p>We propose that entry of the dengue virus to mammalian cells can occur by multiple pathways, and this opens the possibility of the virus being directed to multiple cellular compartments. This would have significant implications in understanding the interaction of the dengue virus with the host cell machinery.</p

A rapid, chromatography-free route to substituted acridine–isoalloxazine conjugates under microwave irradiation

Microwave irradiation was applied to a sequence of condensation reactions from readily available 9-chloroacridines to provide a range of novel acridine–isoalloxazine conjugates. The combination of these two moieties, both of biological interest, was achieved by a chromatography free route

One-pot access to L-5,6-dihalotryptophans and L-alknyltryptophans using tryptophan synthase

The authors thank the European Research Council under the European Union’s Seventh Framework Programme (FP7/2007-2013/ERC grant agreement no 614779, and the University of St Andrews for a studentship (to D. R. M. Smith).We report, for the first time, the use of tryptophan synthase in the generation of L- dihalotryptophans and L-alkynyltryptophans. These previously unpublished compounds will be useful tools in the generation of probes for chemical biology, in biosynthetic diversification and as convenient building blocks for synthesis.PostprintPeer reviewe

LiBeB: High and low energy cosmic ray production and comparison with neutrino induced nucleosynthesis in SNII

We present new calculations of LiBeB production by accelerated particles with various compositions and energy spectra ranging from low energies to relativistic energies, and various ambient medium metallicities ($Z/Z_\odot$). The observed, essentially constant, Be/Fe ratio as a function of $Z/Z_\odot$ can be best understood if the metallicity of the accelerated particles (high energy or low energy) does not vary much with $Z/Z_\odot$. This could be achieved if the particles are accelerated directly from the ejecta of Type II supernovae (SNII) and not from the interstellar medium. Using the observed Be/Fe and the fact that most of the Fe at low $Z/Z_\odot$ is from SNII, we derive the energy content in accelerated particles per SNII (a few times 10$^{50}$ erg). We show that additional $^{11}$B production by neutrinos is consistent with the available data, allowing a neutrino yield from SNII less than or equal to the nominal published yields. We further show that the observed $^6$Li at low $Z/Z_\odot$ suggests that the accelerated particles responsible for the LiBeB at such $Z/Z_\odot$ are confined to low energies and have a relatively high He/O abundance.Comment: 9 pages with 4 emdedded figures, uuencoded, compressed, tared, style files included. In press Nuclei In the Cosmos, Nuclear Physics, Conference Proceeding

Two Large HI Shells in the Outer Galaxy near l=279 degrees

As part of a survey of HI 21-cm emission in the Southern Milky Way, we have detected two large shells in the interstellar neutral hydrogen near l=279 deg. The center velocities are +36 and +59 km/s, which puts the shells at kinematic distances of 7 and 10 kpc. The larger shell is about 610 pc in diameter and very empty, with density contrast of at least 15 between the middle and the shell walls. It has expansion velocity of about 20 km/s and swept up mass of several million solar masses. The energy indicated by the expansion may be as high as 2.4 X 10^53 ergs. We estimate its age to be 15 to 20 million years. The smaller shell has diameter of about 400 pc, expansion velocity about 10 km/s and swept up mass of about 10^6 solar masses. Morphologically both regions appear to be shells, with high density regions mostly surrounding the voids, although the first appears to have channels of low density which connect with the halo above and below the HI layer. They lie on the edge of the Carina arm, which suggests that they may be expanding horizontally into the interarm region as well as vertically out of the disk. If this interpretation is correct, this is the first detection of an HI chimney which has blown out of both sides of the disk.Comment: 21 pages, 14 jpeg figures, accepted for publication in A