Reducing Disparities by way of a Cancer Disparities Research Training Program

Background: For minority populations, there is a continuing disparity in the burden of death and illness from cancer. Research to address this disparity should be conducted by investigators who can best understand and address the needs of culturally diverse communities. However, minorities are under-represented in health-related research. The goal of this project was to develop and evaluate an approach to motivating and preparing master’s degree students for careers dedicated to cancer disparities research. Method: A Cancer Disparities Research Training Program (CDRTP) was initiated in 2010. The program consists of coursework, practicum experiences, and research opportunities. Assessment of the curriculum is based on monitoring achievement of evaluation indicators and includes a quantitative assessment and qualitative approach. Results: In its first three years, the program graduated 20 trainees, all of whom were minorities (18 African Americans and two Asians). When asked about career goals, two-thirds of the trainees indicated interest in pursuing careers in research on cancer prevention and control. The trainees expressed high satisfaction with the courses, instructor, materials, and curriculum. Although trainees had suggestions about course details, evaluations overall were positive. Across focus groups, three recurrent themes emerged regarding activities to enhance the student experience: having a wider variety of topics, more guest speakers, and field trips. Conclusion: The CDRTP was intended to recruit students – primarily African Americans – into research on prevention and control of cancer disparities. Although final evaluation of the program’s overall outcome will not be available for several years, a preliminary evaluation indicates the program is being successful

Topology of Neutral Hydrogen Within the Small Magellanic Cloud

In this paper, genus statistics have been applied to an HI column density map of the Small Magellanic Cloud in order to study its topology. To learn how topology changes with the scale of the system, we provide the study of topology for column density maps at varying resolution. To evaluate the statistical error of the genus we randomly reassign the phases of the Fourier modes while keeping the amplitudes. We find, that at the smallest scales studied ($40 {pc}\leq\lambda\leq 80 {pc}$) the genus shift is in all regions negative, implying a clump topology. At the larger scales ($110 {pc}\leq\lambda\leq 250 {pc}$) the topology shift is detected to be negative in 4 cases and positive (``swiss cheese'' topology) in 2 cases. In 4 regions there is no statistically significant topology shift at large scales

Research on Long-Term Care Homes for Older People in Brazil: Protocol for Scoping Review

LOTUS CONSORTIUM - Improving care in Long-term Care Institutions in Brazil and Europe through Collaboration and ResearchBackground The fast growth of the ageing population in low and middle-income countries, such as Brazil, has allowed little time for social and health care systems to adapt. As the care needs for the most vulnerable and frail older people become increasingly complex, services and governments need to ensure that long term care homes deliver high-quality and evidence-based care to meet their healthcare needs. Aim To examine and map the range of research undertaken in Brazil regarding care homes published in peer reviewed journals. Method This scoping review will consider all relevant peer-reviewed primary studies fully or partly conducted in Brazilian care homes including those which consider workforce (for example, e.g. healthcare professionals, care staff, and management level staff) and care home residents (older people aged 60 years and above), using empirical and original research focused on any health related topic. The searches will be conducted using bibliographic databases (MEDLINE, EMBASE, LILACS and Google Scholar) and manual searching of the reference lists of relevant studies published in English, Portuguese or Spanish from inception up to 2018. Two authors will independently screen each document by title and abstract against the eligibility criteria. In case of disagreement, a third reviewer will be consulted. Data from the included studies will be extracted and reported using tables, graphs, and narrative accounts using elements of content analysis. The Mixed Methods Appraisal Tool will be used to appraise the methodological quality of the included studies

A survey of diffuse interstellar bands in the Andromeda galaxy: optical spectroscopy of M31 OB stars

We present the largest sample to-date of intermediate-resolution blue-to-red optical spectra of B-type supergiants in M31 and undertake the first survey of diffuse interstellar bands (DIBs) in this galaxy. Spectral classifications, radial velocities and interstellar reddenings are presented for 34 stars in three regions of M31. Radial velocities and equivalent widths are given for the 5780 and 6283 DIBs towards 11 stars. Equivalent widths are also presented for the following DIBs detected in three sightlines in M31: 4428, 5705, 5780, 5797, 6203, 6269, 6283, 6379, 6613, 6660, and 6993. All of these M31 DIB carriers reside in clouds at radial velocities matching those of interstellar Na I and/or H I. The relationships between DIB equivalent widths and reddening (E(B-V)) are consistent with those observed in the local ISM of the Milky Way. Many of the observed sightlines show DIB strengths (per unit reddening) which lie at the upper end of the range of Galactic values. DIB strengths per unit reddening are found (with 68% confidence), to correlate with the interstellar UV radiation field strength. The strongest DIBs are observed where the interstellar UV flux is lowest. The mean Spitzer 8/24 micron emission ratio in our three fields is slightly lower than that measured in the Milky Way, but we identify no correlation between this ratio and the DIB strengths in M31. Interstellar oxygen abundances derived from the spectra of three M31 H II regions in one of the fields indicate that the average metallicity of the ISM in that region is 12 + log[O/H] = 8.54 +- 0.18, which is approximately equal to the value in the solar neighbourhood

Demonstrative Evidence - Winning Cases with Exhibits

Speaking on defense exhibits, Gordon Smith (J.D.’78) (left) said one should go through several versions of how to graphically depict something “to find the best delivery.” He discussed the finer points of using a timeline with assistance from Andy Scherffius (J.D.’74). Scherffius, who shared his thoughts on plaintiff exhibits, said the presentation of exhibits at a trial “has become an art and science of its own.

Deep Well Pump Seal

Lifewater International, a Christian non-profit, trains locals to repair water well hand pumps in various third world countries. It would be beneficial to retrofit difficult-to-repair hand pumps with a locally-made pump cylinder such as HydroMission\u27s SlapShot . The majority of the components in the SlapShot can be easily obtained in rural third world villages. However, the thick leather gaskets required to seal the water cylinder during the pumping operation are imported. These thick leather gaskets are expensive, and when they fail, this results in pumps being out of commission for extended periods of time. Lifewater has presented this problem to a team of three undergraduate mechanical engineering students at California Polytechnic State University, San Luis Obispo with the goal of being able to locally source and manufacture an adequate seal to replace the current thick leather seal

Ribosomal S6K1 in POMC and AgRP Neurons Regulates Glucose Homeostasis but Not Feeding Behavior in Mice.

SummaryHypothalamic ribosomal S6K1 has been suggested as a point of convergence for hormonal and nutrient signals in the regulation of feeding behavior, bodyweight, and glucose metabolism. However, the long-term effects of manipulating hypothalamic S6K1 signaling on energy homeostasis and the cellular mechanisms underlying these roles are unclear. We therefore inactivated S6K1 in pro-opiomelanocortin (POMC) and agouti-related protein (AgRP) neurons, key regulators of energy homeostasis, but in contrast to the current view, we found no evidence that S6K1 regulates food intake and bodyweight. In contrast, S6K1 signaling in POMC neurons regulated hepatic glucose production and peripheral lipid metabolism and modulated neuronal excitability. S6K1 signaling in AgRP neurons regulated skeletal muscle insulin sensitivity and was required for glucose sensing by these neurons. Our findings suggest that S6K1 signaling is not a general integrator of energy homeostasis in the mediobasal hypothalamus but has distinct roles in the regulation of glucose homeostasis by POMC and AgRP neurons