Rationale for and design of a generic tiled hierarchical phased array beamforming architecture

The purpose of the phased array beamforming project is to develop a generic flexible efficient phased array receiver platform, using a mixed signal hardware/software-codesign approach. The results will be applicable to any radio (RF) system, but we will focus on satellite receiver (DVB-S) and radar applications. We will present a preliminary mapping of beamforming processing on a tiled architecture and determine its scalability.\ud \ud The functionality, size and cost constraints imply an integrated mixed signal CMOS solution. For a generic flexible multi-standard solution, a software defined radio approach is taken. Because a scalable and dependable solution is needed, a tiled hierarchical architecture is proposed with reconfigurable hardware to regain flexibility. A mapping is provided of beamforming on the proposed architecture. The advantages and disadvantages of each solution are discussed with respect to applicability and scalability.\ud \ud Different beamforming processing solutions can be mapped on the same proposed tiled hierarchical architecture. This provides a flexible, scalable and reconfigurable solution for a wide application domain. Beamforming is a data-driven streaming process which lends itself well for a regular scalable architecture. Beamsteering on the other hand is much more control-oriented and future work will focus on how to support beamsteering on the proposed architecture as well

Non-power-of-Two FFTs: Exploring the Flexibility of the Montium TP

Coarse-grain reconfigurable architectures, like the Montium TP, have proven to be a very successful approach for low-power and high-performance computation of regular digital signal processing algorithms. This paper presents the implementation of a class of non-power-of-two FFTs to discover the limitations and Flexibility of the Montium TP for less regular algorithms. A non-power-of-two FFT is less regular compared to a traditional power-of-two FFT. The results of the implementation show the processing time, accuracy, energy consumption and Flexibility of the implementation

Towards effective modeling and programming multi-core tiled reconfigurable architectures

For a generic flexible efficient array antenna receiver platform a hierarchical reconfigurable tiled architecture has been proposed. The architecture provides a flexible reconfigurable solution, but partitioning, mapping, modeling and programming such systems remains an issue. We will advocate a model-based design approach and propose a single semantic (programming) model for representing the specification, design and implementation. This approach tackles these problems at a higher conceptual level, thereby exploiting the inherent composability and parallelism available in the formalism. A case study illustrates the use of the semantic model with examples from analogue/digital co-design and hardware/software co-design

Multi-core Architectures and Streaming Applications

In this paper we focus on algorithms and reconfigurable multi-core architectures for streaming digital signal processing (DSP) applications. The multi-core concept has a number of advantages: (1) depending on the requirements more or fewer cores can be switched on/off, (2) the multi-core structure fits well to future process technologies, more cores will be available in advanced process technologies, but the complexity per core does not increase, (3) the multi-core concept is fault tolerant, faulty cores can be discarded and (4) multiple cores can be configured fast in parallel. Because in our approach processing and memory are combined in the cores, tasks can be executed efficiently on cores (locality of reference). There are a number of application domains that can be considered as streaming DSP applications: for example wireless baseband processing (for HiperLAN/2, WiMax, DAB, DRM, and DVB), multimedia processing (e.g. MPEG, MP3 coding/decoding), medical image processing, colour image processing, sensor processing (e.g. remote surveillance cameras) and phased array radar systems. In this paper the key characteristics of streaming DSP applications are highlighted, and the characteristics of the processing architectures to efficiently support these types of applications are addressed. We present the initial results of the Annabelle chip that we designed with our approach

Smart Chips for Smart Surroundings -- 4S

The overall mission of the 4S project (Smart Chips for Smart Surroundings) was to define and develop efficient flexible, reconfigurable core building blocks, including the supporting tools, for future Ambient System Devices. Reconfigurability offers the needed flexibility and adaptability, it provides the efficiency needed for these systems, it enables systems that can adapt to rapidly changing environmental conditions, it enables communication over heterogeneous wireless networks, and it reduces risks: reconfigurable systems can adapt to standards that may vary from place to place or standards that have changed during and after product development. In 4S we focused on heterogeneous building blocks such as analogue, hardwired functions, fine and coarse grain reconfigurable tiles and microprocessors. Such a platform can adapt to a wide application space without the need for specialized ASICs. A novel power aware design flow and runtime system was developed. The runtime system decides dynamically about the near-optimal application mapping to the given hardware platform. The overall concept was verified on hardware platforms based on an existing SoC and in a second step with novel silicon. DRM (Digital Radio Mondiale) and MPEG4 Video applications have been implemented on the platforms demonstrating the adaptability of the 4S concept

Advantages of robotic assistance over a manual approach in simulated subretinal injections and its relevance for gene therapy

Subretinal injection is a method for gene delivery to treat genetic diseases of the photoreceptors and retinal pigment epithelium. A reflux-free subretinal injection is important to allow effective, safe, and cost-effective gene therapy to the retina. We report on a comparison between manual and robotic assistance in simulated subretinal injections using an artificial retina model. Nine surgeons carried out the procedure with and without the Preceyes Surgical System, using an OPMI Lumera 700 Zeiss surgical microscope equipped with intra-operative optical coherence tomography. Success in creating a bleb without reflux, injection duration, drift, tremor, and increase in the diameter of the puncture hole were analyzed. Robotic assistance improved drift (median 16 vs 212 mu m), tremor (median 1 vs 18 mu m), enlargement of the retinal hole, and allowed for prolonged injection times (median 52 vs 29 sec). Robotic assistance allowed higher rate of bleb formation (8/9 vs 4/9 attempts) with a moderate reduction in reflux (7/9 vs 8/9 attempts) in this artificial model. Robotic assistance can significantly contribute to subretinal injections and provide quantifiable parameters in assessing surgical and clinical success of novel retinal gene therapies.Ophthalmic researc

Nuclear Eg5 (kinesin spindle protein) expression predicts docetaxel response and prostate cancer aggressiveness

Novel biomarkers predicting prostate cancer (PCa) aggressiveness and docetaxel therapy response of PCa patients are needed. In this study the correlation between nuclear Eg5-expression, PCa docetaxel response and PCa aggressiveness was assessed. Immunohistochemical staining for nuclear Eg5 was performed on 117 archival specimens from 110 PCa patients treated with docetaxel between 2004 and 2012. Samples were histologically categorized as positive/negative. Median follow-up time from diagnosis was 11.6 years. Nuclear Eg5-expression was significantly related to docetaxel response (p=0.036) in tissues acquired within three years before docetaxel initiation. Nuclear Eg5-expression was not related to Gleason-score (p=0.994). Survival of patients after docetaxel initiation did not differ based on nuclear Eg5-expression (p=0.540). Analyzing samples taken before hormonal therapy, overall survival and time to docetaxel use were significantly decreased in patients with nuclear Eg5-expressing tumors (p<0.01). Eg5-positive nuclei were found more frequently in T4-staged tumors (p=0.04), Gleason 8-10 tumors (p=0.08), and in metastasized tumors (p<0.01). Multivariate analyses indicated that nuclear Eg5-expression may be an independent parameter for tumor aggressiveness. Limitations of a retrospective analysis apply. In conclusion, nuclear Eg5-expression may be a predictive biomarker for docetaxel response in metastatic castrate-resistant PCa patients and a prognostic biomarker for hormone-naive PCa patients. Prospective validation studies are needed