High-Performance Carbon Electrodes Modified with Polyaniline for Stable and Selective Anion Separation

Capacitive deionization (CDI) is a technology used for water desalination and ion recovery based on the use of capacitive electrodes. Typically, the porous carbon electrodes used for CDI display limited ion storage capacity and selectivity due to the mechanism of ion storage in the electric double layer, but impressive improvements have been achieved using alternative, redox-based electrode materials, including conducting polymers like polyaniline (PAni). PAni is capable of capturing anions based on redox chemistry, but it degrades at anodic potentials typically used in CDI. In this work, we employed a multi-channel membrane CDI cell to map the stability window of a porous carbon electrode modified with PAni by controlling the anodic potential. We demonstrated for the first time that applying a potential as low as + 0.35 V (vs. Ag/AgCl) yields a stable and high chloride removal capacity (65 mgCl/gAnode) with charge and coulombic efficiencies close to 100% for CDI. Furthermore, this is first work to explore the selectivity of the PAni-modified CDI electrodes towards chloride in binary solutions, evidencing that chloride is preferred regardless the valence of the competing anions. We believe that this work provides an important contribution for a larger figure, one in which CDI can be used for both high-performance water desalination, and efficient anion-selective removal and recovery.This work was supported by the European Research Council (ERC Consolidator Grant 682444, E-motion, PI L.d.S)". L.A.M.R. thanks the Sao Paulo State Research Foundation (FAPESP, grant 2017/19838-5). The authors thank Kaíque S. G. C. Oliveira for the synthesis of the PAC material, Dr Sidharam Pujari for the AES measurements, and Ellen Dautzenberg for the nitrogen adsorption/desorption measurements. The authors also would like to thank the participants of the Advanced Materials for Chemical Selectivity group of the Laboratory of Organic Chemistry (WUR), particularly the CDI team, for the fruitful discussions

Long-term changes in dysnatremia incidence in the ICU: a shift from hyponatremia to hypernatremia

Background: Dysnatremia is associated with adverse outcome in critically ill patients. Changes in patients or treatment strategies may have affected the incidence of dysnatremia over time. We investigated long-term changes in the incidence of dysnatremia and analyzed its association with mortality. Methods: Over a 21-year period (1992–2012), all serum sodium measurements were analyzed retrospectively in two university hospital ICUs, up to day 28 of ICU admission for the presence of dysnatremia. The study period was divided into five periods. All serum sodium measurements were collected from the electronic databases of both ICUs. Serum sodium was measured at the clinical chemistry departments using standard methods. All sodium measurements were categorized in the following categories: 160 mmol/L. Mortality was determined at 90 days after ICU admission. Results: In 80,571 ICU patients, 913,272 serum sodium measurements were analyzed. A striking shift in the pattern of ICU-acquired dysnatremias was observed: The incidence of hyponatremia almost halved (47–25 %, p  155 mmol/L) increased dramatically over the years. On ICU day 10 this incidence was 0.7 % in the 1992–1996 period, compared to 6.3 % in the 2009–2012 period (p < 0.001). More severe dysnatremia was associated with significantly higher mortality throughout the 21-year study period (p < 0.001). Conclusions: In two large Dutch cohorts, we observed a marked shift in the incidence of dysnatremia from hyponatremia to hypernatremia over two decades. As hypernatremia was mostly ICU acquired, this strongly suggests changes in treatment as underlying causes. This shift may be related to the increased use of sodium-containing infusions, diuretics, and hydrocortisone. As ICU-acquired hypernatremia is largely iatrogenic, it should be—to an important extent—preventable, and its incidence may be considered as an indicator of quality of care. Strategies to prevent hypernatremia deserve more emphasis; therefore, we recommend that further study should be focused on interventions to prevent the occurrence of dysnatremias during ICU stay

Short-range correlations and meson exchange currents in photonucleon emission

One-nucleon emission processes induced by photon absorption are studied by considering short-range correlations effects. At energies above the giant resonance region the validity of the direct knock-out model has been tested by comparison with continuum Random Phase Approximation results. Nucleon re-scattering effects have been considered by using an optical potential. The role of the electromagnetic convection, magnetization and meson exchange currents has been investigated as a function of both excitation energy and momentum transfer. The short-range correlation effects have been studied by using various correlation functions. We found that the nucleon photo-emission cross section is rather sensitive to the presence of short-range correlations at large values of nucleon emission angle. In this region, however, the effects of meson exchange currents are even larger than those produced by short-range correlations.Comment: 37 pages, 20 figures in postscript, Text in LaTe

Calsequestrin as a risk factor in Graves’ hyperthyroidism and Graves’ ophthalmopathy patients

Background: The pathogenesis of Graves’ ophthalmopathy (GO), Graves’ hyperthyroidism (GH) and the mechanisms for its link to thyroid autoimmunity are poorly understood. Our research focuses on the role of the skeletal muscle calcium binding protein calsequestrin (CASQ1) in thyroid. We measured the concentration of the CASQ1 protein correlating levels with parameters of the eye signs, CASQ1 antibody levels and CASQ1 gene polymorphism rs3838284. Methods: CASQ1 protein was measured by quantitative Western Blotting. The protein concentrations were expressed as pmol/mg total protein by reference to CASQ1 standards. Results: Western blot analysis showed the presence of two forms of CASQ1 in the thyroid. The mean concentration of CASQ1 protein was significantly reduced in patients with Graves’ disease, compared to thyroid from control subjects with multi-nodular goitre or thyroid cancer. Although in patients with GO it was lower than that, compared with patients with GH this difference was not significant. Reduced CASQ1 in Graves’ thyroid correlated with the homozygous genotype of the rs3838284 CASQ1 polymorphism. Conclusions: Decreased CASQ1 in the thyroid of patients with Graves’ disease compared to thyroid from control subjects is not explained but may reflect consumption of the protein during an autoimmune reaction against CASQ1 in the thyroid

Prevalence and incidence rate of hospital admissions related to medication between 2008 and 2013 in The Netherlands

Purpose: In 2009 a Dutch guideline was published containing recommendations to reduce Hospital Admissions Related to Medications (HARMs). This study aims to examine

Hamstring muscles: Architecture and innervation

Knowledge of the anatomical organization of the hamstring muscles is necessary to understand their functions, and to assist in the development of accurate clinical and biomechanical models. The hamstring muscles were examined by dissection in six embalmed human lower limbs with the purpose of clarifying their gross morphology. In addition to obtaining evidence for or against anatomical partitioning ( as based on muscle architecture and pattern of innervation), data pertaining to architectural parameters such as fascicular length, volume, physiological cross-sectional area, and tendon length were collected. For each muscle, relatively consistent patterns of innervation were identified between specimens, and each was unique with respect to anatomical organization. On the basis of muscle architecture, three regions were identified within semimembranosus. However, this was not completely congruent with the pattern of innervation, as a primary nerve branch supplied only two regions, with the third region receiving a secondary branch. Semitendinosus comprised two distinct partitions arranged in series that were divided by a tendinous inscription. A singular muscle nerve or a primary nerve branch innervated each partition. In the biceps femoris long head the two regions were supplied via a primary nerve branch which divided into two primary branches or split into a series of branches. Being the only muscle to cross a single joint, biceps femoris short head consisted of two distinct regions demarcated by fiber direction, with each innervated by a separate muscle nerve. Architecturally, each muscle differed with respect to parameters such as physiological cross-sectional area, fascicular length and volume, but generally all partitions within an individual muscle were similar in fascicular length. The long proximal and distal tendons of these muscles extended into the muscle bellies thereby forming elongated musculotendinous junctions. Copyright (C) 2005 S. Karger AG, Basel

Differential vitreous dye diffusion following microplasmin or plasmin pre-treatment.

Purpose: Plasmin and microplasmin are related enzymes that differ mainly in size. The differential effect of plasmin and microplasmin on vitreous structure, protein degradation, and dye diffusion through porcine vitreous was evaluated. Methods: The enzymatic effect was examined using a number of approaches on fresh porcine eyes: (1) structural integrity of vitreous after a 2-hr incubation using the electron microscope (EM); (2) effect on soluble proteins within the vitreous using gel electrophoresis after incubation at various time points over a 24-hr period; (3) fluorescein dye diffusion within the vitreous cavity measured over a 1-hr period following a 2-hr incubation. The chosen enzymatic activities for plasmin 0.5 IU and microplasmin 125 mu g were within the clinical range, and were chosen for equipotence. A saline control was also used in all experiments. Results: Significant structural changes were seen with both microplasmin and plasmin when examined by EM. Gel electrophoresis showed that microplasmin and plasmin digested the same proteins, mainly molecular weights above 50 kDa. The enzymatic effect was noticeable earlier in microplasmin-treated eyes and was more significant by the end of the incubation period. Differential fluorescein diffusion rates were seen between normal saline, plasmin, and microplasmin within the vitreous cavity. The greatest diffusion rate was seen with microplasmin and was statistically significantly higher than plasmin. Conclusion: Microplasmin and plasmin have a similar enzymatic effect on vitreous. However, an equipotent amount of microplasmin appears to have a more extended effect on vitreous gel. This may, in part, be related to its smaller size allowing it to diffuse more readily through the vitreous matri