Inlet and airframe compatibility for a V/STOL fighter/attack aircraft with top-mounted inlets

Aerodynamic force and inlet pressure data are obtained for 9.5% force and pressure models of a V/STOL fighter/attack aircraft configuration with top mounted twin inlets. Data are presented from tests conducted in the Ames Unitary Wind Tunnels at Mach numbers of 0.6, 0.9, and 1.2 at angles of attack up to 27 deg. and angles of sideslip up to 12 deg. Trimmed aerodynamic characteristics and inlet performance are compared for three different leading edge extension (LEX) configurations. The effects of wing leading and trailing-edge flaps on the inlet are also determined. Maneuver perfromance is calculated form combined force and inlet pressure data. The largest of the three LEX sizes tested gives the best airplane maneuver performance. Wing flap deflections improved inlet recovery at all Mach numbers

Test results at transonic speeds on a contoured over-the-wing propfan model

A semispan wing/body model with a powered highly loaded propeller has been tested to provide data on the propulsion installation drag of advanced propfan-powered aircraft. The model had a supercritical wing with a contoured over-the-wing nacelle. It was tested in the Ames Research Center's (ARC) 14-foot Transonic Wind Tunnel at a total pressure of 1 atm. The test was conducted at angles of attack from -0.5 to 4 deg at Mach numbers ranging from 0.6 to 0.8. The test objectives were to determine propeller performance, exhaust jet effects, propeller slipstream interference drag, and total powerplant installation drag. Test results indicated a total powerplant installation drag of 82 counts (0.0082) at a Mach number of 0.8 and a lift coefficient of 0.5, which is approximately 29 percent of a typical airplane cruise drag

Top-mounted inlet system feasibility for transonic-supersonic fighter aircraft

The more salient findings are presented of recent top inlet performance evaluations aimed at assessing the feasibility of top-mounted inlet systems for transonic-supersonic fighter aircraft applications. Top inlet flow field and engine-inlet performance test data show the influence of key aircraft configuration variables-inlet longitudinal position, wing leading-edge extension planform area, canopy-dorsal integration, and variable incidence canards-on top inlet performance over the Mach range of 0.6 to 2.0. Top inlet performance data are compared with those or more conventional inlet/airframe integrations in an effort to assess the viability of top-mounted inlet systems relative to conventional inlet installations

Top-mounted inlet performance for a V/STOL fighter/attack aircraft configuration

Inlet flow-field and compressor-face performance data were obtained for a 0.095-scale model of vertical/short take-off landing (V/STOL) fighter/attack aircraft configuration with twin top-mounted inlets. Tests were conducted at Mach numbers from 0.6 to 2.0 and angles of attack and sideslip up to 27 deg. and 12 deg., respectively. Reynolds number was held constant at 9.8 x 10 to the 6th power per meter. The effects of inlet location, wing leading-edge extension (LEX) planform area, canopy-dorsal integration, variable incidence canards, and wing leading- and trailing-edge flap deflections were determined. The results show that at Mach numbers up to 0.9, distortion is relatively low (20% or less) at all angles of attack and sideslip. However, at Mach numbers of 1.2 and above, operation may be restricted because of either high distortion or low pressure recovery (80% or less), or both. These difficulties may be overcome with alterations to the LEX/canopy/body juncture

From infancy to adolescence: fifteen years of continuous treatment with hydroxyurea in sickle cell anemia

Despite documented laboratory and clinical benefits of hydroxyurea for children with sickle cell anemia (SCA), the drug\u27s long-term safety and efficacy remains poorly defined. The HUSOFT trial and extension study examined feasibility, toxicity, and hematological efficacy of hydroxyurea in infants with SCA.This report describes HUSOFT participants who have continued hydroxyurea therapy for 15 years. With IRB approval, medical records were reviewed for clinical, laboratory, and growth parameters.Twenty-eight infants enrolled in the original 2-year HUSOFT study received open-label liquid hydroxyurea at 20 mg/kg/day; 17 completed the extension study with dose escalation to 30 mg/kg/day. Eight of these 17 (6 girls and 2 boys, all HbSS) have continued on daily hydroxyurea for at least 15 years (median age at last follow-up 17.6 years) without interruption. All hematologic indices (Hb concentration, mean corpuscular volume (MCV), fetal hemoglobin) showed sustained effect after 15 years. The median maximum tolerated dose of hydroxyurea has decreased from 30 to 26 mg/kg/day (range 19.5-31.2); neutropenia [absolute neutrophil count (ANC) \u3c 1.0 x 10/L] prompting temporary drug discontinuation occurred a total of 10 times in 4 subjects and there was no severe neutropenia (ANC \u3c 0.5 x 10/L). Growth rates over 15 years continued at the 50th percentile for both height and weight, and puberty occurred without delay (age range 10-14 years). There were 5.1 vaso-occlusive events (pain and acute chest syndrome)/100 patient years, 7.3 packed red blood cell transfusions/100 patient years. No malignancies, strokes, or deaths occurred. At last follow up, all subjects were at appropriate grade level (10-12 grade) with no history of repeated grades.A cohort of young teenagers with SCA who initiated treatment in infancy have had sustained and continued hematological benefits for a decade and a half. Growth and sexual development are normal and comparable to the general pediatric population. Continuous hydroxyurea therapy since infancy appears safe and efficacious in SCA

Hypusination of Eif5a Regulates Cytoplasmic TDP-43 Aggregation and Accumulation in a Stress-Induced Cellular Model

TAR DNA-binding protein 43 (TDP-43) is a nuclear RNA/DNA binding protein involved in mRNA metabolism. Aberrant mislocalization to the cytoplasm and formation of phosphorylated/aggregated TDP-43 inclusions remains the hallmark pathology in a spectrum of neurodegenerative diseases, including frontotemporal disorders and Alzheimer\u27s disease. Eukaryotic Translation Initiation Factor 5A undergoes a unique post-translation modification of lysine to hypusine (K50), which determines eIF5A binding partners. We used a sodium arsenite-induced cellular stress model to investigate the role of hypusinated eIF5A (eIF5AHypK50) in governing TDP-43 cytoplasmic mislocalization and accumulation in stress granule. Our proteomics and functional data provide evidence that eIF5A interacts with TDP-43 in a hypusine-dependent manner. Additionally, we showed that following stress TDP-43 interactions with eIF5AHypK50 were induced both in the cytoplasm and stress granules. Pharmacological reduction of hypusination or mutations of lysine residues within the hypusine loop decreased phosphorylated and insoluble TDP-43 levels. The proteomic and biochemical analysis also identified nuclear pore complex importins KPNA1/2, KPNB1, and RanGTP as interacting partners of eIF5AHypK50. These findings are the first to provide a novel pathway and potential therapeutic targets that require further investigation in models of TDP-43 proteinopathies

Free induction decay of single spins in diamond

We study both theoretically and experimentally the free induction decay (FID) of the electron spin associated with a single nitrogen-vacancy defect in high purity diamond, where the main source of decoherence is the hyperfine interaction with a bath of $^{13}$C nuclear spins. In particular, we report a systematic study of the FID signal as a function of the strength of a magnetic field oriented along the symmetry axis of the defect. On average, an increment of the coherence time by a factor of $\sqrt{5/2}$ is observed at high magnetic field in diamond samples with a natural abundance of $^{13}$C nuclear spins, in agreement with numerical simulations and theoretical studies. Further theoretical analysis shows that this enhancement is independent of the concentration of nuclear spin impurities. By dividing the nuclear spin bath into shells and cones, we theoretically identify which nuclear spins are responsible for the observed dynamics.Comment: 16 pages, 7 figure

Gas emissions, minerals, and tars associated with three coal fires, Powder River Basin, USA.

Ground-based surveys of three coal fires and airborne surveys of two of the fires were conducted near Sheridan, Wyoming. The fires occur in natural outcrops and in abandoned mines, all containing Paleocene-age subbituminous coals. Diffuse (carbon dioxide (CO(2)) only) and vent (CO(2), carbon monoxide (CO), methane, hydrogen sulfide (H(2)S), and elemental mercury) emission estimates were made for each of the fires. Additionally, gas samples were collected for volatile organic compound (VOC) analysis and showed a large range in variation between vents. The fires produce locally dangerous levels of CO, CO(2), H(2)S, and benzene, among other gases. At one fire in an abandoned coal mine, trends in gas and tar composition followed a change in topography. Total CO(2) fluxes for the fires from airborne, ground-based, and rate of fire advancement estimates ranged from 0.9 to 780mg/s/m(2) and are comparable to other coal fires worldwide. Samples of tar and coal-fire minerals collected from the mouth of vents provided insight into the behavior and formation of the coal fires