9,036 research outputs found
Gravitational Waves Probe the Coalescence Rate of Massive Black Hole Binaries
We calculate the expected nHz--Hz gravitational wave (GW) spectrum from
coalescing Massive Black Hole (MBH) binaries resulting from mergers of their
host galaxies. We consider detection of this spectrum by precision pulsar
timing and a future Pulsar Timing Array. The spectrum depends on the merger
rate of massive galaxies, the demographics of MBHs at low and high redshift,
and the dynamics of MBH binaries. We apply recent theoretical and observational
work on all of these fronts. The spectrum has a characteristic strain
, just below the detection limit from
recent analysis of precision pulsar timing measurements. However, the amplitude
of the spectrum is still very uncertain owing to approximations in the
theoretical formulation of the model, to our lack of knowledge of the merger
rate and MBH population at high redshift, and to the dynamical problem of
removing enough angular momentum from the MBH binary to reach a GW-dominated
regime.Comment: 31 Pages, 8 Figures, small changes to match the published versio
Helicobacter pylori interstrain restriction-modification diversity prevents genome subversion by chromosomal DNA from competing strains
Helicobacter pylori, bacteria that colonize the human gastric mucosa, possess a large number of genes for restrictionâmodification (RâM) systems, and essentially, every strain possesses a unique complement of functional and partial RâM systems. Nearly half of the H.pylori strains studied possess an active type IIs RâM system, HpyII, with the recognition sequence GAAGA. Recombination between direct repeats that flank the RâM cassette allows for its deletion whereas strains lacking hpyIIRM can acquire this cassette through natural transformation. We asked whether strains lacking HpyII RâM activity can acquire an active hpyIIRM cassette [containing a 1.4 kb kanamycin resistance (aphA) marker], whether such acquisition is DNase sensitive or resistant and whether restriction barriers limit acquisition of chromosomal DNA. Our results indicate that natural transformation and conjugationâlike mechanisms may contribute to the transfer of large (4.8 kb) insertions of chromosomal DNA between H.pylori strains, that inactive or partial RâM systems can be reactivated upon recombination with a functional allele, consistent with their being contingency genes, and that H.pylori RâM diversity limits acquisition of chromosomal DNA fragments of â„1 kb
QSO's from Galaxy Collisions with Naked Black Holes
In the now well established conventional view (see Rees [1] and references
therein), quasi-stellar objects (QSOs) and related active galactic nuclei (AGN)
phenomena are explained as the result of accretion of plasma onto giant black
holes which are postulated to form via gravitational collapse of the high
density regions in the centers of massive host galaxies. This model is
supported by a wide variety of indirect evidence and seems quite likely to
apply at least to some observed AGN phenomena. However, one surprising set of
new Hubble Space Telescope (HST) observations [2-4] directly challenges the
conventional model, and the well known evolution of the QSO population raises
some additional, though not widely recognized, difficulties. We propose here an
alternative possibility: the Universe contains a substantial independent
population of super-massive black holes, and QSO's are a phenomenon that occurs
due to their collisions with galaxies or gas clouds in the intergalactic medium
(IGM). This hypothesis would naturally explain why the QSO population declines
very rapidly towards low redshift, as well as the new HST data.Comment: plain TeX file, no figures, submitted to Natur
Dynamical modeling of collective behavior from pigeon flight data: flock cohesion and dispersion
Several models of flocking have been promoted based on simulations with
qualitatively naturalistic behavior. In this paper we provide the first direct
application of computational modeling methods to infer flocking behavior from
experimental field data. We show that this approach is able to infer general
rules for interaction, or lack of interaction, among members of a flock or,
more generally, any community. Using experimental field measurements of homing
pigeons in flight we demonstrate the existence of a basic distance dependent
attraction/repulsion relationship and show that this rule is sufficient to
explain collective behavior observed in nature. Positional data of individuals
over time are used as input data to a computational algorithm capable of
building complex nonlinear functions that can represent the system behavior.
Topological nearest neighbor interactions are considered to characterize the
components within this model. The efficacy of this method is demonstrated with
simulated noisy data generated from the classical (two dimensional) Vicsek
model. When applied to experimental data from homing pigeon flights we show
that the more complex three dimensional models are capable of predicting and
simulating trajectories, as well as exhibiting realistic collective dynamics.
The simulations of the reconstructed models are used to extract properties of
the collective behavior in pigeons, and how it is affected by changing the
initial conditions of the system. Our results demonstrate that this approach
may be applied to construct models capable of simulating trajectories and
collective dynamics using experimental field measurements of herd movement.
From these models, the behavior of the individual agents (animals) may be
inferred
"5 Days in August" â How London Local Authorities used Twitter during the 2011 riots
© IFIP International Federation for Information Processing 2012This study examines effects of microblogging communications during emergency events based on the case of the summer 2011 riots in London. During five days in August 2011, parts of London and other major cities in England suffered from extensive public disorders, violence and even loss of human lives. We collected and analysed the tweets posted by the official accounts maintained by 28 London local government authorities. Those authorities used Twitter for a variety of purposes such as preventing rumours, providing official information, promoting legal actions against offenders and organising post-riot community engagement activities. The study shows how the immediacy and communicative power of microblogging can have a significant effect at the response and recovery stages of emergency events
Taken by strum: ukuleles and participatory music-making in Hamilton, Aotearoa/New Zealand
Ethnographic study of ukulele playing in Hamilton, N
Optimal MRI sequences for 68Ga-PSMA-11 PET/MRI in evaluation of biochemically recurrent prostate cancer.
BackgroundPET/MRI can be used for the detection of disease in biochemical recurrence (BCR) patients imaged with 68Ga-PSMA-11 PET. This study was designed to determine the optimal MRI sequences to localize positive findings on 68Ga-PSMA-11 PET of patients with BCR after definitive therapy. Fifty-five consecutive prostate cancer patients with BCR imaged with 68Ga-PSMA-11 3.0T PET/MRI were retrospectively analyzed. Mean PSA was 7.9 ± 12.9 ng/ml, and mean PSA doubling time was 7.1 ± 6.6 months. Detection rates of anatomic correlates for prostate-specific membrane antigen (PSMA)-positive foci were evaluated on small field of view (FOV) T2, T1 post-contrast, and diffusion-weighted images. For prostate bed recurrences, the detection rate of dynamic contrast-enhanced (DCE) imaging for PSMA-positive foci was evaluated. Finally, the detection sensitivity for PSMA-avid foci on 3- and 8-min PET acquisitions was compared.ResultsPSMA-positive foci were detected in 89.1% (49/55) of patients evaluated. Small FOV T2 performed best for lymph nodes and detected correlates for all PSMA-avid lymph nodes. DCE imaging performed the best for suspected prostate bed recurrence, detecting correlates for 87.5% (14/16) of PSMA-positive prostate bed foci. The 8-min PET acquisition performed better than the 3-min acquisition for lymph nodes smaller than 1 cm, detecting 100% (57/57) of lymph nodes less than 1 cm, compared to 78.9% (45/57) for the 3-min acquisition.ConclusionPSMA PET/MRI performed well for the detection of sites of suspected recurrent disease in patients with BCR. Of the MRI sequences obtained for localization, small FOV T2 images detected the greatest proportion of PSMA-positive abdominopelvic lymph nodes and DCE imaging detected the greatest proportion of PSMA-positive prostate bed foci. The 8-min PET acquisition was superior to the 3 min acquisition for detection of small lymph nodes
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