Influence of external factors on dielectric permittivity of Rochelle salt: humidity, annealing, stresses, electric field

The present work contains results of experimental investigation of external factors, such as dessicating/wetting, thermal annealing, uniaxial and hydrostatic pressures on dielectric permittivity of Rochelle salt crystals. The obtained results are compared with available literature data. A conslusion is made that the dispersion of experimental data can be attributed to internal polar point defects in crystals and to influence of storage conditions. The obtained results are analyzed within the phenomenological Landau approach

ВИКОРИСТАННЯ РОСЛИННОЇ СИРОВИНИ В ТЕХНОЛОГІЇ СИРКОВИХ МАС

It was established, that the everyday rations of the Ukraine population deficient by the content of almost all nutrients, including alimentary fiber by 30 %, vitamins by 30-55 %. In this connection, creating a wide assortment of functional foods for the correction of population rations nutrition is actual task of the various sectors of the food industry. In the production of dairy products it is possible to introduction various biological additives and therefore the correction of their composition and nutritional value accordance with requirements of norms of the theory of adequate nutrition. Important role for human health played consumption of vegetables, fruits, berries and products manufactured from vegetable raw material. Interesting is the development of technology of products based on milk and vegetable raw materials, because vegetable raw materials allows natural dairy products to enrich with vitamins, pectins, minerals and natural coloring substances.  Установлено, что ежедневные рационы населения Украины дефицитные по содержанию практически всех пищевых веществ, в частности, пищевых волокон на 30 %, витаминов на 30-55 %.В связи с этим создание широкого ассортимента функциональных продуктов для коррекции рационов питания населения является актуальной задачей различных отраслей пищевой промышленности. При производстве молочных продуктов возможно введение различных биологических добавок и таким образом коррекция их состава и пищевой ценности в соответствии с требованиями норм теории адекватного питания.Важную роль для здоровья человека играет употребление овощей, фруктов, ягод, а также продукции, изготовленной на основе растительного сырья.Интересным является разработка технологии продуктов на основе молочно-овощного сырья, поскольку растительное сырье позволяет обогатить молочные продукты натуральными витаминами, пектинами, минеральными веществами, а также природными красящими веществами.Встановлено, що щоденні раціони населення України дефіцитні за вмістом практично всіх харчових речовин, зокрема, харчових волокон на 30 %, вітамінів на 30-55 %. У зв'язку з цим створення широкого асортименту функціональних продуктів для корекції раціонів харчування населення є актуальним завданням  різних галузей харчової промисловості. При виробництві молочних продуктів можливим є введення різноманітних біологічних добавок і таким чином корекція  їх складу і харчової цінності відповідно до вимог норм теорії адекватного харчування. Важливу роль для здоров´я людини відіграє вживання овочів, фруктів, ягід, а також продукції, виготовленої на основі рослинної сировини. Цікавим є розроблення технології продуктів на основі молочно-овочевої сировини, оскільки рослинна сировина дозволяє збагатити молочні продукти натуральними вітамінами, пектинами, мінеральними речовинами, а також природними фарбуючими речовинами. &nbsp

Global prospective case series of ERCPs using a single-use duodenoscope

Background The first commercialized single-use duodenoscope was cleared by the US Food and Drug Administration in December 2019. Data regarding endoscopic retrograde cholangiopancreatography (ERCP) using a single-use duodenoscope are needed on a broader range of cases conducted by endoscopists with varying levels of experience in a wide range of geographic areas. Methods 61 endoscopists at 22 academic centers in 11 countries performed ERCP procedures in adult patients aged ? 18. Outcomes included ERCP completion for the intended indication, rate of crossover to a reusable endoscope, device performance ratings, and serious adverse events (SAEs). Results Among 551 patients, 236 (42.8 %) were aged &gt;65, 281 (51.0 %) were men, and 256 (46.5 %) had their procedure as an inpatient. ERCPs included 196 (35.6 %) with American Society for Gastrointestinal Endoscopy complexity of grades 3 4. A total of 529 ERCPs (96.0 %) were completed: 503 (91.3 %) using only the single-use duodenoscope, and 26 (4.7 %) with crossover to a reusable endoscope. There were 22 ERCPs (4.0 %) that were not completed, of which 11 (2.0 %) included a crossover and 11 (2.0 %) were aborted cases (no crossover). Median ERCP completion time was 24.0 minutes. Median overall satisfaction with the single-use duodenoscope was 8.0 (scale of 1 to 10 [best]). SAEs were reported in 43 patients (7.8 %), including 17 (3.1 %) who developed post-ERCP pancreatitis. Conclusions In academic medical centers over a wide geographic distribution, endoscopists with varying levels of experience using the first marketed single-use duodenoscope had good ERCP procedural success and reported high performance ratings for this device.</p

Use and perceived effectiveness of non-analgesic medical therapies for chronic pancreatitis in the United States

Aliment Pharmacol Ther 2011; 33: 149–159Effectiveness of medical therapies in chronic pancreatitis has been described in small studies of selected patients.To describe frequency and perceived effectiveness of non-analgesic medical therapies in chronic pancreatitis patients evaluated at US referral centres.Using data on 516 chronic pancreatitis patients enrolled prospectively in the NAPS2 Study, we evaluated how often medical therapies [pancreatic enzyme replacement therapy (PERT), vitamins/antioxidants (AO), octreotide, coeliac plexus block (CPB)] were utilized and considered useful by physicians.Oral PERT was commonly used (70%), more frequently in the presence of exocrine insufficiency (EI) (88% vs. 61%, P  < 0.001) and pain (74% vs. 59%, P  < 0.002). On multivariable analyses, predictors of PERT usage were EI (OR 5.14, 95% CI 2.87–9.18), constant (OR 3.42, 95% CI 1.93–6.04) or intermittent pain (OR 1.98, 95% CI 1.14–3.45). Efficacy of PERT was predicted only by EI (OR 2.16, 95% CI 1.36–3.42). AO were tried less often (14%) and were more effective in idiopathic and obstructive vs. alcoholic chronic pancreatitis (25% vs. 4%, P  = 0.03). Other therapies were infrequently used (CPB – 5%, octreotide – 7%) with efficacy generally <50%.Pancreatic enzyme replacement therapy is commonly utilized, but is considered useful in only subsets of chronic pancreatitis patients. Other medical therapies are used infrequently and have limited efficacy.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/79114/1/j.1365-2036.2010.04491.x.pd

Test of octupole coupled 5- state in 146Nd using proton inelastic scattering

The inelastic scattering of 35 MeV protons has been used to excite seven states below 2.1 MeV in 146Nd. A comparison between a coupled-channels calculation that assumes an octupole coupled structure for the 5- state at 1.517 MeV and the observed cross section suggests that the wave function of this state includes only a small two-quasiparticle component. In addition, the present results indicate that the level at 2.073 MeV, previously assigned Jπ=4-, actually has Jπ=3-

An analysis of the utilisation of chemoprophylaxis against Pneumocystis jirovecii pneumonia in patients with malignancy receiving corticosteroid therapy at a cancer hospital

Pneumocystis jirovecii pneumonia (PCP) is associated with high mortality in immunocompromised patients without human immunodeficiency virus infection. However, chemoprophylaxis is highly effective. In patients with solid tumours or haematologic malignancy, several risk factors for developing PCP have been identified, predominantly corticosteroid therapy. The aims of this study were to identify the potentially preventable cases of PCP in patients receiving corticosteroid therapy at a tertiary care cancer centre and to estimate the frequency of utilisation of chemoprophylaxis in these patients. Two retrospective reviews were performed. Over a 10-year period, 14 cases of PCP were identified: no cases were attributable to failed chemoprophylaxis, drug allergy or intolerance. During a 6-month period, 73 patients received high-dose corticosteroid therapy (⩾25 mg prednisolone or ⩾4 mg dexamethasone daily) for ⩾4 weeks. Of these, 22 (30%) had haematologic malignancy, and 51 (70%) had solid tumours. Fewer patients with solid tumours received prophylaxis compared to patients with haematologic malignancy (3.9 vs 63.6%, P<0.0001). Guidelines for PCP chemoprophylaxis in patients with haematologic malignancy or solid tumours who receive corticosteroid therapy are proposed. Successful primary prevention of PCP in this population will require a multifaceted approach targeting the suboptimal prescribing patterns for chemoprophylaxis

Focus on the management of thunderclap headache: from nosography to treatment

Thunderclap headache (TCH) is an excruciating headache characterized by a very sudden onset. Recognition and accurate diagnosis of TCH are important in order to rule out the various, serious underlying brain disorders that, in a high percentage of cases, are the real cause of the headache. Primary TCH, which may recur intermittently and generally has a spontaneous, benign evolution, can thus be diagnosed only when all other potential underlying causes have been excluded through accurate diagnostic work up. In this review, we focus on the management of TCH, paying particular attention to the diagnostic work up and treatment of the condition

Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis

Pancreatitis is a complex, progressively destructive inflammatory disorder. Alcohol was long thought to be the primary causative agent, but genetic contributions have been of interest since the discovery that rare PRSS1, CFTR, and SPINK1 variants were associated with pancreatitis risk. We now report two significant genome-wide associations identified and replicated at PRSS1-PRSS2 (1×10-12) and x-linked CLDN2 (p < 1×10-21) through a two-stage genome-wide study (Stage 1, 676 cases and 4507 controls; Stage 2, 910 cases and 4170 controls). The PRSS1 variant affects susceptibility by altering expression of the primary trypsinogen gene. The CLDN2 risk allele is associated with atypical localization of claudin-2 in pancreatic acinar cells. The homozygous (or hemizygous male) CLDN2 genotype confers the greatest risk, and its alleles interact with alcohol consumption to amplify risk. These results could partially explain the high frequency of alcohol-related pancreatitis in men – male hemizygous frequency is 0.26, female homozygote is 0.07