Triple GEM Tracking Detectors for the BM@N Experiment

BM@N (Baryonic Matter at the Nuclotron) is the fixed target experiment aimed to study nuclear matter in the relativistic heavy ion collisions at the Nuclotron accelerator in JINR. The BM@N tracking system is based on Gas Electron Multipliers (GEM) detectors, mounted inside the BM@N analyzing magnet. The structure of the GEM detectors and the results of study of their characteristics are presented. The GEM detectors are integrated into the BM@N experimental setup and data acquisition system. The results of the first test of the GEM tracking system in the technical run with the deuteron beam are shortly reviewed

Three-body correlations in direct reactions: Example of 6^{6}Be populated in (p,n)(p,n) reaction

The $^{6}$Be continuum states were populated in the charge-exchange reaction $^1$H($^{6}$Li,$^{6}$Be)$n$ collecting very high statistics data ($\sim 5 \times 10^6$ events) on the three-body $\alpha$+$p$+$p$ correlations. The $^{6}$Be excitation energy region below $\sim 3$ MeV is considered, where the data are dominated by contributions from the $0^+$ and $2^+$ states. It is demonstrated how the high-statistics few-body correlation data can be used to extract detailed information on the reaction mechanism. Such a derivation is based on the fact that highly spin-aligned states are typically populated in the direct reactions.Comment: submitted to Physical Review

10He low-lying states structure uncovered by correlations

The 0+ ground state of the 10He nucleus produced in the 3H(8He,p)10He reaction was found at about $2.1\pm0.2$ MeV (\Gamma ~ 2 MeV) above the three-body 8He+n+n breakup threshold. Angular correlations observed for 10He decay products show prominent interference patterns allowing to draw conclusions about the structure of low-energy excited states. We interpret the observed correlations as a coherent superposition of the broad 1- state having a maximum at energy 4-6 MeV and the 2+ state above 6 MeV, setting both on top of the 0+ state "tail". This anomalous level ordering indicates that the breakdown of the N=8 shell known in 12Be thus extends also to the 10He system.Comment: 5 pages, 5 figure

New insight into the low-energy 9^9He spectrum

The spectrum of $^9$He was studied by means of the $^8$He($d$,$p$)$^9$He reaction at a lab energy of 25 MeV/n and small center of mass (c.m.) angles. Energy and angular correlations were obtained for the $^9$He decay products by complete kinematical reconstruction. The data do not show narrow states at $\sim$1.3 and $\sim$2.4 MeV reported before for $^9$He. The lowest resonant state of $^9$He is found at about 2 MeV with a width of $\sim$2 MeV and is identified as $1/2^-$. The observed angular correlation pattern is uniquely explained by the interference of the $1/2^-$ resonance with a virtual state $1/2^+$ (limit on the scattering length is obtained as $a > -20$ fm), and with the $5/2^+$ resonance at energy $\geq 4.2$ MeV.Comment: 5 pages, 4 figures, 2 table

Mitoxantrone Quantification by HPLC-MS/MS in Caco-2 Culture Media

Mitoxantrone is a marker substrate of breast cancer resistance protein (BCRP). BCRP is involved in a number of pharmacokinetic drug-drug interactions. The transporter’s possible saturability makes it advisable to use low concentrations of mitoxantrone for in vitro studies. Consequently, mitoxantrone quantification requires   a method with high sensitivity.The aim of the study was to develop and validate a procedure for mitoxantrone quantification in Caco-2 culture media by HPLC-MS/MS.Materials and methods.  The  authors  used  an  Ultimate  3000  HPLC  system  and a TSQ Fortis triple quadrupole mass spectrometer by Thermo Fisher Scientific and a Selectra C18 column (4.6×100 mm, 5 μm, 100 Å) by United Chemical Technologies. The elution ran in a gradient mode with a mobile phase of 1% formic acid solution and methanol. Experimental parameters were as follows: eluent flow rate, 0.3 mL/min; separation column temperature, 35 °C; injection volume, 5  μL; ana lysis time, 10 min; approximate mitoxantrone retention time, 5.51 min. The sample preparation involved protein precipitation from the culture medium with methanol, followed by centrifugation at 13,000 g for 10 min. The detection was performed using electrospray ionisation in the positive ion mode. Detection parameters were   as follows: electrospray voltage, 3700 V; sheath gas flow rate, 50 L/min; auxiliary    gas flow rate, 10 L/min; sweep gas flow rate, 1 L/min; ion-transfer tube temperature, 300 °C; and evaporator temperature, 350 °C. The detection was set at mass transitions of m/z 455 to 88.2 and m/z 455 to 358.1, with the collision energy for these transitions amounting to 25 V and 18 V, respectively. The source fragmentation was at 0, and the CID gas pressure was at 2 mTorr.Results. The analytical procedure showed selectivity, high sensitivity (limit of detection, 10 nmol/L; lower limit of quantification, 50 nmol/L), accuracy, precision, and linearity in the concentration range of 50–1000 nmol/L. The authors observed no carryover or matrix effects. A simulation of real-life storage conditions demonstrated high stability of mitoxantrone samples. Thus, the analytical procedure enables preclinical evaluation of medicinal product effects on the functional activity of BCRP, based on assessing the transcellular mitoxantrone transport in the presence of a test product.Conclusion. The authors developed and validated the analytical procedure for mitoxantrone quantification in Caco-2 culture media by HPLC-MS/MS

\b{eta}-delayed three-proton decay of 31Ar

The beta decay of 31Ar, produced by fragmentation of a 36Ar beam at 880 MeV/nucleon, was investigated. Identified ions of 31Ar were stopped in a gaseous time projection chamber with optical readout allowing to record decay events with emission of protons. In addition to \b{eta}-delayed emission of one and two protons we have clearly observed the beta-delayed three-proton branch. The branching ratio for this channel in 31Ar is found to be 0.07(2)%.Comment: 5 pages, 3 figures, submitted to Physical Rev.