240 research outputs found

    Strengthening "Giving Voice to Values" in business schools by reconsidering the "invisible hand" metaphor

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    The main contention of this paper is that our ability to embed a consideration of values into business school curricula is hampered by certain normative parameters that our students have when entering the classroom. If we don't understand the processes of valuation that underpin our students' reasoning, our ethics teaching will inevitably miss its mark. In this paper, we analyze one of the most prevalent metaphors that underpin moral arguments about business, and reveal the beliefs and assumptions that underpin it. By revisiting the content of Adam Smith's "invisible hand" metaphor, we show that the moral content of the metaphor has been significantly misconstrued through its subsequent reception in economic theory. The "Giving Voice to Values" (GVV) pedagogy aims to enable students to act on their tacit values and address the rationalizations that they may encounter for not acting on these values (Gentile in Giving voice to values. How to speak your mind when you know what's right, Yale University Press, Yale, 2010a; Discussions about ethics in the accounting classroom: student assumptions and faculty paradigms, Darden Business Publishing, 2010b. http://store.darden.virginia.edu/Syllabus%20Copy/Discussions-about-Ethics-in-Accounting_S.pdf; Educating for values-driven leadership across the curriculum: giving voice to values, Business Expert Press, New York, 2013). We believe our analysis can strengthen the employment of GVV in three ways: (1) understanding tacit blockages to moral action, i.e., how students' belief in the moral efficacy of the invisible hand could undermine their own sense of moral duty; (2) addressing common rationalizations that may emerge from different assumptions about morally appropriate courses of action in the workplace; and (3) resolving values conflicts on how to act

    Toward optimal control of flat plate photobioreactors: the greenhouse analogy?

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    Abstract: The cultivation of algae in photo-bioreactors shows similarities to crop cultivation in greenhouses, especially when the reactors are driven by sun light. Advanced methodologies for dynamic optimization and optimal control for greenhouses are known from earlier research. The aim here is to extend these methodologies to microalgae cultivated in a flat plate photo-bioreactor. A one-state space model for the algal biomass in the reactor is presented. The growth rate vs. light curve is parameterized on the basis of experimental evidence. Spatial distribution of light and growth rate between the plates is also considered. The control variable is the dilution rate. Dynamic optimal control trajectories are presented for various choices of goal function and external solar irradiation trajectories over a horizon of 3 days. It was found that the algae present in the reactor at final time represent a value for the future. Numerical and theoretical results suggest that the control is bang-(singular-)bang, with a strong dependence on the weather. The optimal biomass also depends on the available light, and achieving it to reach a new optimal steady cycle after a prolonged change in weather may take several days. A preliminary theoretical analysis suggests a control law that maximizes the effective growth rate. The analysis shows that like in the greenhouse case, the co-state of the algal biomass plays a pivot role in developing on-line controllers

    In vitro and in vivo evaluation of [I-123]-VEGF(165) as a potential tumor marker

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    peer reviewedOne of the research challenges in oncology is to develop new biochemical methods for noninvasive tumor therapy evaluation to determine,whether the chemotherapeutics is effective. Vascular endothelial growth factor (VEGF) was labeled with radioiodine and evaluated in vitro as well as in vivo, using A2058, a melanoma cell line overexpressing VEGFR-1 and -2. Saturation binding analysis with [I-125]-VEGF resulted in a K-d of 0.1 nM. Internalization assays indicate the preserved ligand induced internalization and metabolization of the tracer. Biodistribution studies with [I-123]-VEGF in wild type and A2058 tumor-bearing athymic mice showed low background activity and a tumor to reference tissue ratio of maximum 6.12. These results suggest that [I-123]-VEGF is a potentially suitable tracer for tumor therapy evaluation. (c) 2005 Elsevier Inc. All rights reserved

    Mobile system for precise aero delivery with global reach network capability

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    This paper discusses the current status of the development of the mobile aerial delivery system to be further employed in a variety of different applications. High accuracy of the developed system enables its use in precision troop resupply, precise sensors placement, urban warfare reconnaissance and other similar operations. This paper overviews the overall system architecture and components of the developed aero delivery system itself and then proceeds with describing the current status of integrating it with an advanced deployment platform, unmanned aerial system, to achieve mobility and autonomy of operations. The paper also discusses some other systems in development pursuing similar goals and reviews some novel applications that become possible with the developed aerial delivery system
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