26 research outputs found
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Teacher Evaluations in the Special Education Setting: Voices from the Field
National policy mandates have placed greater accountability on districts and schools to improve the outcomes of every student, including students with disabilities. Teacher evaluation systems that accurately identify effective teachers and their impact on student learning have resulted in the widespread design and implementation of new teacher evaluation systems. Nevertheless, limited exploration related to the evaluation of special education teachers exists. Using a qualitative, multi-case study research design, we sought to gain insight into the perceptions and experiences of special education teachers and administrators to better understand (a) the relationship between teacher evaluation and teacher effectiveness; (b) the ways in which educators approach the challenges of applying teacher evaluation systems for special education teachers; and (c) the ways in which teacher evaluation processes support the professional growth and development of special education teachers. The challenges involved in evaluating special education teachers with a uniform teacher evaluation protocol instrument are presented. The need to be able to accurately appraise special education teachers within an inclusive classroom setting, apply criteria from the observation protocol to special education students, and lack of appraisersďż˝ knowledge of the roles and expertise of special education teachers were identified. Recommendations for improvement are provided.Educatio
An Assessment of the Links Between International Diversification, Product Diversification, Performance and Risk Within Service Corporations
Services currently account for the dominant share of the workforce in all developed nations and are the fastest growing sector of employment in most developing nations. Services comprise approximately two-thirds of the GDP (gross domestic product) or total domestic output of final goods and services in highly industrialized nations from the OECD (Organization for Cooperation and Development). They make up almost half of the GDP in developing nations. All economic forecasts predict that services will continue to grow and account for the vast majority of future economic expansion throughout the world. Despite these facts, services have been studied infrequently among management scholars. This neglect stems from an historical lack of available data on services. However, recent advances in technology have made their study feasible. The major theories of the firm have been developed using manufacturing enterprises, and so may not be applicable to services. Similarly, most empirical work in the business literature uses manufacturing data. This dissertation attempts to fill this void in the literature.
Much of the research in management has focused on finding variables that account for performance (Christensen and Montgomery, 1981; Hambrick and Mason, 1984; Hanson and Wernerfelt, 1989). Performance has been a popular topic because it is necessarily a consequence of strategy, and because performance typically is the key objective or goal that defines strategy. Therefore, academics have looked to strategies to account for performance. Among these are international diversification and product diversification. Many researchers have linked these terms, including Miller and Pras (1980), Grant, Jammine and Thomas (1988), Kim, Hwang and Burgers (1989) and Geringer, Beamish and daCosta (1989). However, no definitive relationships have been discovered. This work continues this stream of research while focusing on services. Specifically the relationships between international diversification, product diversification and performance observed among manufacturing firms by Hitt, Hoskisson and Kim (1997) are tested for U.S. service firms. The results show that the curvilinear line between international diversification and performance which is moderated by product diversification was not observed for services. This may be due to the differences between goods and services, which have been noted by a number of marketing scholars (Zeithaml, Parasuraman and Berry, 1990; Lovelock, 1983; Gronroos, 1990). To extend the analysis, the relationship between international diversification, product diversification and risk was also analyzed. Based on previous work a U-shaped curve was anticipated between international diversification and risk, which was moderated by product diversification. Interestingly, evidence of an inverted U-shaped curved line between international diversification and risk was found. The implications of these findings are given for managers and academics. Suggestions for future research are also provided
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Measuring teacher effectiveness through meaningful evaluation : how can reform models apply to general education and special education teachers?
textWhile teacher quality is recognized as a critical component in school reform, and the pursuit of new teacher evaluation systems has gained national attention, the question of whether proposed teacher assessment models meet the needs of special education teachers has gone largely unnoticed. Current efforts to design teacher evaluation processes that accurately distinguish between effective and ineffective teachers must take into account the difficulties of using new, innovative evaluation systems to appraise teachers who serve students with disabilities. Important differences in the roles, expertise, and circumstances in which special education teachers carry out their responsibilities result in challenges related to the use of observation protocols in evaluating instructional practices, obtaining valid measures of student progress, and understanding the relevance of teacher credentials (i.e., degrees earned and certification) in the special education setting. Through this qualitative research dissertation, the researcher sought to gain insight into the perceptions and experiences of special education teachers and administrators to better understand (a) the relationship between teacher evaluation and teacher effectiveness; (b) the ways in which educators approach the challenges of applying teacher evaluation systems for special education teachers; and (c) the ways in which teacher evaluation processes support the professional growth and development of special education teachers.Educational Administratio
Pilot trial of paclitaxel-trastuzumab adjuvant therapy for early stage breast cancer: a trial of the ECOG-ACRIN cancer research group (E2198)
BACKGROUND:
Blockade of human epidermal growth factor receptor type 2 (HER2) has dramatically improved outcome for patients with HER2-positive breast cancer. Trastuzumab, an anti-HER2 monoclonal antibody, has previously demonstrated improvement in overall survival (OS) in patients with metastatic and early stage HER2-positive breast cancer. However, trastuzumab can cause congestive heart failure (CHF) with an increased frequency for patients who have also received an anthracycline. The current trial was designed to evaluate the impact of the duration of trastuzumab on CHF.
METHODS:
E2198 included 227 eligible women with histologically confirmed stage II or IIIA HER2-positive breast cancer. The patients were randomised to receive 12 weeks of paclitaxel and trastuzumab followed by four cycles of doxorubicin and cyclophosphamide (abbreviated Arm) or the aforementioned treatment with additional 1 year of trastuzumab (conventional Arm). The primary end point was to evaluate the safety of this variable duration of trastuzumab therapy, particularly cardiac toxicity defined as CHF or left ventricular ejection fraction decrease >10%. Secondary end points included disease-free survival (DFS) and OS.
RESULTS:
Compared with 12-week treatment with trastuzumab, 1 year of trastuzumab-based therapy did not increase the frequency or severity of cardiac toxicity: three patients on the abbreviated Arm and four on the conventional Arm experienced CHF. The 5-year DFS was 76% and 73% for the abbreviated and conventional Arms, respectively, with a hazard ratio (HR) of 1.3 (95% CI: 0.8-2.1; P=0.3). There was also no statistically significance difference in OS (HR, 1.4; P=0.3).
CONCLUSIONS:
Compared with 12 weeks of treatment, 1 year of treatment with trastuzumab did not significantly increase the risk of cardiac toxicity. Although not powered for efficacy comparisons, the longer duration of trastuzumab therapy did not demonstrate a signal for marked superiority
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Teacher Evaluation in the Special Education Setting: Voices from the Field
This article uses a qualitative, multi-case study research design to gain insight into the perceptions and experiences of special education teachers and administrators
Persistent behavioral impairment caused by embryonic methylphenidate exposure in zebrafish
Effects of HIV Protease Inhibitor Ritonavir on Akt-Regulated Cell Proliferation in Breast Cancer
Purpose
These studies were designed to determine whether ritonavir inhibits breast cancer in vitro and in vitro and, if so, how.
Experimental Design
Ritonavir effects on breast cancer cell growth were studied in the estrogen receptor (ER)-positive lines MCF7 and T47D and in the ER-negative lines MDA-MB-436 and MDA-MB-231. Effects of ritonavir on Rb-regulated and Akt-mediated cell proliferation were studied. Ritonavir was tested for inhibition of a mammary carcinoma xenograft.
Results
ER-positive estradiol-dependent lines (IC50, 12–24 µmol/L) and ER-negative (IC50, 45 µmol/L) lines exhibit ritonavir sensitivity. Ritonavir depletes ER-α levels notably in ER-positive lines. Ritonavir causes G1 arrest, depletes cyclin-dependent kinases 2, 4, and 6 and cyclin D1 but not cyclin E, and depletes phosphorylated Rb and Ser473 Akt. Ritonavir induces apoptosis independent of G1 arrest, inhibiting growth of cells that have passed the G1 checkpoint. Myristoyl-Akt, but not activated K-Ras, rescues ritonavir inhibition. Ritonavir inhibited a MDA-MB-231 xenograft and intratumoral Akt activity at a clinically attainable serum Cmax of 22 ± 8 µmol/L. Because heat shock protein 90 (Hsp90) substrates are depleted by ritonavir, ritonavir effects on Hsp90 were tested. Ritonavir binds Hsp90 (KD, 7.8 µmol/L) and partially inhibits its chaperone function. Ritonavir blocks association of Hsp90 with Akt and, with sustained exposure, notably depletes Hsp90. Stably expressed Hsp90α short hairpin RNA also depletes Hsp90, inhibiting proliferation and sensitizing breast cancer cells to low ritonavir concentrations.
Conclusions
Ritonavir inhibits breast cancer growth in part by inhibiting Hsp90 substrates, including Akt. Ritonavir may be of interest for breast cancer therapeutics and its efficacy may be increased by sustained exposure or Hsp90 RNA interference