Cardiopoietic cell therapy for advanced ischemic heart failure: results at 39 weeks of the prospective, randomized, double blind, sham-controlled CHART-1 clinical trial

Cardiopoietic cells, produced through cardiogenic conditioning of patients' mesenchymal stem cells, have shown preliminary efficacy. The Congestive Heart Failure Cardiopoietic Regenerative Therapy (CHART-1) trial aimed to validate cardiopoiesis-based biotherapy in a larger heart failure cohort

Polyaniline thin films in sensors for detection of toxic welding vapors

In this paper the possibilities of applying sensors based on filters with surface acoustic waves (SAW) for the detection of harmful products in welding processes are analyzed. This review discusses the sensing mechanism and configurations of the sensors. The principles of SAW sensors are considered with special emphasis on the application of conducting polyaniline nanocomposites as sensitive thin layers in sensors for the detection of CO, NO2, and COCl2. The literature suggests the use of In2O3 as a dopant for CO and NO2 detection sensors, and ethylenediamine and phenylenediamine in COCl2 sensors. The paper presents original results of modeling of sensors that are designed for detection of CO and NO2 for which there are experimental data in the literature. The results obtained based on this model are in excellent agreement with results from the literature, which shows the validity of modeling. Based on the developed modeling methods, calculations were done for sensors for the detection of these gases in which the structure was the surface of quartz. From these modeling results it can be concluded that the use of the quartz substrate provides better sensitivity. In addition, the quartz sensors are thermally stable.U radu su analizirane mogućnosti primene senzora u čijoj osnovi se nalaze filtri sa površinskim akustičkim talasom (PAT), za detekciju štetnih produkata u procesu zavarivanja. Objašnjeni su principi rada PAT senzora sa posebnim osvrtom na primenu elektroprovodnih polianilinskih nanokompozitnih materijala – polianilin/In2O3 i etilendiamin i fenilendiamin polianilinskih nanokompozita kao osetljivih tankih slojeva za detekciju CO, NO2 i COCl2. Prikazan je deo originalnih rezultata modelovanja PAT senzora koji su namenjeni detekciji pomenutih gasova. Rezultati dobijeni na bazi sopstvenog modela poređeni su sa rezultatima iz literature. Pokazano je da se ovim na činom modelovanja može uspešno odrediti koncentracija štetnih gasova u okruženju

Effect of ageing on optical and thermal properties of YBa2Cu3O7-delta

Photoacoustic phase and amplitude spectra of YBa2Cu3O7-delta samples synthesised 18 years ago were measured and numerically analysed. The value of thermal diffusivity obtained on the aged samples was lower than the values obtained for fresh samples. Far infrared spectra of YBa2Cu3O7-delta samples synthesised 18 years ago were recorded and analysed enabling determination of reflectivity peak phonon frequencies present at room temperature. X-ray diffraction analysis and far infrared reflectivity measurements enabled determination of a slight change of the oxygen content with time. The YBa2Cu3O7-delta samples synthesised 18 years ago still remained superconducting, which was confirmed by resistivity measurements of the samples between 50 K and room temperature where the critical temperature was reduced from 93 to 73 K. Atomic force microscopy, scanning electron microscopy and energy dispersive X-ray microanalytical measurements were also performed confirming the composition of the sample

Alirocumab and cardiovascular outcomes after acute coronary syndrome

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Alirocumab and Cardiovascular Outcomes after Acute Coronary Syndrome

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Risk Categorization Using New American College of Cardiology/American Heart Association Guidelines for Cholesterol Management and Its Relation to Alirocumab Treatment Following Acute Coronary Syndromes

10.1161/CIRCULATIONAHA.119.042551CIRCULATION140191578-158