Alien Registration- Slauenwhite, William E. (Monmouth, Kennebec County)

https://digitalmaine.com/alien_docs/16411/thumbnail.jp

Bubble-size distributions produced by wall injection of air into flowing freshwater, saltwater and surfactant solutions

As air is injected into a flowing liquid, the resultant bubble characteristics depend on the properties of the injector, near-wall flow, and flowing liquid. Previous research has shown that near-wall bubbles can significantly reduce skin-friction drag. Air was injected into the turbulent boundary layer on a test section wall of a water tunnel containing various concentrations of salt and surfactant (Triton-X-100, Union Carbide). Photographic records show that the mean bubble diameter decreased monotonically with increasing salt and surfactant concentrations. Here, 33 ppt saltwater bubbles had one quarter, and 20 ppm Triton-X-100 bubbles had one half of the mean diameter of freshwater bubbles.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/47073/1/348_2004_Article_850.pd

Leishmania infantum exoproducts inhibit human invariant NKT cell expansion and activation

Leishmania infantum is one of the major parasite species associated with visceral leishmaniasis, a severe form of the disease that can become lethal if untreated. This obligate intracellular parasite has developed diverse strategies to escape the host immune response, such as exoproducts (Exo) carrying a wide range of molecules, including parasite virulence factors, which are potentially implicated in early stages of infection. Herein, we report that L. infantum Exo and its two fractions composed of extracellular vesicles (EVs) and vesicle-depleted-exoproducts (VDEs) inhibit human peripheral blood invariant natural killer T (iNKT) cell expansion in response to their specific ligand, the glycolipid a-GalactosylCeramide (a-GalCer), as well as their capacity to promptly produce IL-4 and IFN¿. Using plate-bound CD1d and a-GalCer, we found that Exo, EV, and VDE fractions reduced iNKT cell activation in a dose-dependent manner, suggesting that they prevented a-GalCer presentation by CD1d molecules. This direct effect on CD1d was confirmed by the observation that CD1d:a-GalCer complex formation was impaired in the presence of Exo, EV, and VDE fractions. Furthermore, lipid extracts from the three compounds mimicked the inhibition of iNKT cell activation. These lipid components of L. infantum exoproducts, including EV and VDE fractions, might compete for CD1-binding sites, thus blocking iNKT cell activation. Overall, our results provide evidence for a novel strategy through which L. infantum can evade immune responses of mammalian host cells by preventing iNKT lymphocytes from recognizing glycolipids in a TCR-dependent manner.This work was supported by Fundação para a Ciência e Tecnologia (FCT)/Ministério da Educação e da Ciência (MEC), co-funded by FEDER under the PT2020 Partnership Agreement through the Research Unit NO. 4293; by European Community’s Seventh Framework Programme under grant agreement No. 603182 (Project MuLeVaClin). RB and BP-C were supported by fellowships from the FCT (No. SFRH/BD/88005/2012) and European Community’s Seventh Framework Programme Project NMTryPI (No. 603240-2), respectively. We also thank the Investissements d’Avenir programme ANR-2010-MIDI-005, France

Alien Registration- Slauenwhite, Asa A. (Monmouth, Kennebec County)

https://digitalmaine.com/alien_docs/16376/thumbnail.jp

Alien Registration- Slauenwhite, William E. (Monmouth, Kennebec County)

https://digitalmaine.com/alien_docs/16411/thumbnail.jp

Senior Show 2020 036

This exhibition, which was featured in the Robert and Elaine Stein Galleries at Wright State University, featuring works by the senior class of 2007. This exhibition ran from April 1 to May 2, 2020, featuring works of from a variety of artists in various mediums.https://corescholar.libraries.wright.edu/restein_exhibitions_all/1439/thumbnail.jp

Alien Registration- Slauenwhite, Asa A. (Monmouth, Kennebec County)

https://digitalmaine.com/alien_docs/16376/thumbnail.jp