Estimation of surface potential of lymphocytes from patients with leukemia using kelvin probe mode

The feasibilities of the Kelvin probe mode were shown to estimate a surface potential of lympho cytes from the patients with leukemia. Having compared the values of the surface potential obtained by the traditional method of microelectrophoresis and by the Kelvin probe mode, it was established that the use of the atomic force microscope made it possible to obtain data which were of specified diagnostic importance while studying lymphocyte functional status at different stages in leucopoiesis and indicated progression of the pathological proces

Application of technologies of atomic force microscope investigation for evaluation of structure and properties of blood cells’ surfaces

With application of techniques of atomic force microscope investigation, we studied properties and topography of blood cells’ surfaces in patients with acute lymphoblastic and myeloblastic leucosis. It was stated that development of acute forms of lymphoblastic and myeloblastic types of proliferation is accompanied with reduction of stiffness of cell surface and increase of surface potentia

Changes of the biophysical properties of blood corpuscles from the elderly under mechanical stress in vitro

Features of biophysical properties in blood cells from the elderly under mechanical stress applied in vitro have been studied. This stress was reported to trigger the signaling pathway engaged by purinergic receptor activation. The stiffness of the cell surfaces of red blood cells, granulocytes, lymphocytes, and platelets decreased, and the surface potential became more positive. Our findings add to the knowledge of the effect of mechanical deformation on leukocytes and platelets, which are the key regulators of homeostatic processes in the microvasculature, and on red blood cells involved in the regulation of vascular tone in arterioles and tissue oxygenation in the elderl

Конструкция системы охлаждения двигателей внутреннего сгорания

For the English abstract and full text of the article please see the attached PDF-File (English version follows Russian version). ABSTRACT The article proposes authors’ design to reduce the temperature of exhaust gases on the surface of pipelines of the resonator and the catalyst. To do so plates of various geometric shapes and sizes are arranged perpendicularly and (or) at an angle to their longitudinal axis, spaced apart from each other. The expediency of using this variant of modernization of the exhaust system of the internal combustion engine is supported by theoretical and experimental studies, the reliability of which is confirmed with a confidence probability of 0,95. The regression dependencies obtained give grounds for recommending their own order of regulating the rate of cooling of a pipeline that removes exhaust gases, in accordance with their initial parameters and subsequent dynamics of indicators. In addition, during the experiment it was possible to reveal the physical picture of the process of heating and cooling of a pipeline along its length. Keywords: internal combustion engine, theoretical and experimental studies, regression dependencies, cooling system, design, vehicle, temperature.Текст аннотации на англ. языке и полный текст статьи на англ. языке находится в прилагаемом файле ПДФ (англ. версия следует после русской версии). В предлагаемой конструкции для снижения температуры отработавших газов на поверхности трубопроводов резонатора и катализатора перпендикулярно и (или) под углом к их продольной оси на расстоянии друг от друга расположены пластины различной геометрической формы и размеров, которые могут чередоваться между собой. Целесообразность использования этого варианта модернизации выхлопной системы двигателя внутреннего сгорания подкреплена проведёнными теоретическими и экспериментальными исследованиями, достоверность которых подтверждена с доверительной вероятностью 0,95. Полученные регрессионные зависимости дают основание рекомендовать порядок регулирования скорости остывания трубопровода, отводящего отработавшие газы, в соответствии с их исходными параметрами и последующей динамикой показателей. Кроме того, в ходе эксперимента удалось выявить физическую картину процесса нагревания и остывания трубопровода по длине

The Gnevyshev Gap Effect in Galactic Cosmic Rays

Abstract During the last three solar cycles and in a wide energy range of galactic cosmic rays both the modulation and the variability of the intensity demonstrate effects related to the Gnevyshev Gap (GG) -a substantial decrease once or twice during the maximum phase of each solar cycle of a parameter that generally varies in phase with the cycle. The GG-effect also manifests itself in the behaviour of both the strength of the average interplanetary magnetic field and the power of its fluctuating component. The energy dependence of the GGeffect in the modulation and in the variability of the cosmic ray intensity was found to be different. The start of the GG-effect in the cosmic ray modulation practically coincides with a change in the energy dependence of the cosmic ray modulation

Migration-related detention centers : The challenges of an ecological perspective with a focus on justice

Background: In recent years, border control and migration-related detention have become increasingly widespread practices affecting the lives of undocumented migrants, their families, and communities at large. In spite of the concern within academia, few studies have directly witnessed the life and experiences of people confined to migration-related detention centers. In the medical and psychological fields, a considerable body of research has demonstrated the pathogenic nature of detention in terms of mental health, showing an association between length of detention and severity of distress. Nevertheless, it was limited to the assessment of individuals’ clinical consequences, mainly focusing on asylum seekers. There currently exists a need to adopt an ecological perspective from which to study detained migrants’ experiences as context-dependent, and influenced by power inequalities. This paper addresses this gap. Discussion: Drawing upon advances in community psychology, we illustrate an ecological framework for the study of migration-related detention contexts, and their effects on the lives of detained migrants and all people exposed to them. Making use of existing literature, Kelly’s four principles (interdependence, cycling of resources, adaptation, succession) are analyzed at multiple ecological levels (personal, interpersonal, organizational, communal), highlighting implications for future research in this field. A focus on justice, as a key-dimension of analysis, is also discussed. Wellbeing is acknowledged as a multilevel, dynamic, and value-dependent phenomenon. Summary: In presenting this alternative framework, the potential for studying migration-related detention through an ecological lens is highlighted, pointing the way for future fields of study. We argue that ecological multilevel analyses, conceptualized in terms of interdependent systems and with a focus on justice, can enhance the comprehension of the dynamics at play in migration-related detention centers, providing an effective tool to address the multi-level challenges of doing research within them. Furthermore, they can contribute to the development of policies and practices concerned with health, equality, and human rights of all people exposed to migration-related detention. Consistent with these assumptions, empirical studies adopting such a framework are strongly encouraged. These studies should use mixed and multi-method culturally situated designs, based on the development of collaborative and empowering relationships with participants. Ethnographic approaches are recommended.Fundação para a Ciência e Tecnologia (FCT

The change of electrical properties of blood corpuscles under in vitro mechanical stress

Changes in the electrical properties of blood corpuscles that are experiencing mechanical stress modeled in vitro have been studied. An increase in the concentration of ATP molecules in the intercellular space in response to the mechanical effect of moving plasma layers both in the blood of healthy people and patients with acute lymphoblastic leukemia is demonstrate

Estimation of surface potential of lymphocytes from patients with leukemia using kelvin probe mode

The feasibilities of the Kelvin probe mode were shown to estimate a surface potential of lympho cytes from the patients with leukemia. Having compared the values of the surface potential obtained by the traditional method of microelectrophoresis and by the Kelvin probe mode, it was established that the use of the atomic force microscope made it possible to obtain data which were of specified diagnostic importance while studying lymphocyte functional status at different stages in leucopoiesis and indicated progression of the pathological proces

Nanotechnological approach to evaluation of mechanical properties of cell surfaces during stimulation and blockade of adrenoceptors

yesBSUWe used a new nanotechnological approach for evaluation of functional activity of adrenoceptors during treatment of cell surfaces with various drugs. Local elasticity maps by nanoindentation points were constructed, which show the targets for drugs on transporter cells under natural conditions. The applied approach allowed identifi cation of structural transformations in the membrane leading to changes in its elasticity, which can be used in cell physiology studies for controlling the processes of cell signalin

Nanotechnological approach to evaluation of mechanical properties of cell surfaces during stimulation and blockade of adrenoceptors

We used a new nanotechnological approach for evaluation of functional activity of adrenoceptors during treatment of cell surfaces with various drugs. Local elasticity maps by nanoindentation points were constructed, which show the targets for drugs on transporter cells under natural conditions. The applied approach allowed identifi cation of structural transformations in the membrane leading to changes in its elasticity, which can be used in cell physiology studies for controlling the processes of cell signalingyesBS