Baltic provenance of top-Famennian siliciclastic material of the northern Rhenish Massif, Rhenohercynian zone of the Variscan orogen

The provenance of top-Famennian sedimentary rocks linked to the Hangenberg Crisis from the northern Rhenish Massif (Germany) was investigated by the means of detrital zircon U-Pb geochronology. Based on the obtained age spectra, three main tectonothermal domains are recognized as possible sources: Paleo- and Mesoproterozoic (~ 2000–1000 Ma) units of Baltica and Early Paleozoic Caledonian orogen (~ 500–400 Ma). Our interpretation of the detritus having been derived from northern source areas, i.e., Baltica and the Scandinavian Caledonides, with a minor input of German-Polish (Rügen-Pomeranian) Caledonides, contradicts the traditional view that, during the Upper Devonian, the northern Rhenish Massif was supplied by detritus from the south. Complementary mineralogical, textural and geochemical analyses point to a derivation of the detritus of Drewer and Hangenberg Sandstones mainly from felsic, recycled continental crust. The elevated concentrations of Pb and Zn in the studied sections are a feature attributed to hydrothermal alteration related to the terminal Devonian synsedimentary volcanism or post-depositional Variscan deformation

Late Paleoproterozoic and Mesoproterozoic magmatism of the Nico Perez Terrane (Uruguay):Tightening up correlations in southwestern Gondwana

New geochronological, isotopic and geochemical data were obtained from the late Paleoproterozoic and Mesoproterozoic magmatic units of the Nico Pérez Terrane (Uruguay). A U-Pb LA-ICP-MS zircon age of 1768 ± 11 Ma confirms the Statherian age for the Illescas rapakivi intrusion, being thus comparable with the age of the Campanero Unit felsic orthogneisses. Though both the Illescas and Campanero intrusions exhibit dominantly granitic, meta- to peraluminous compositions, the first shows a dominant shoshonitic and ferroan composition, whereas high-K calc-alkaline and magnesian to ferroan compositions characterize orthogneisses of the Campanero Unit. Additionally, Sm/Yb and LaN/YbN ratios indicate that both suites were emplaced in a thickened crust, whereas Lu-Hf zircon data of the Illescas granite together with available Sm-Nd data of the Campanero Unit point to significant recycling of an older, Archean and/or Paleoproterozoic crust of the Nico Pérez Terrane. Results suggest a common origin for both the Illescas and Campanero magmatism, probably related to a post-collisional/post-orogenic setting. On the other hand, metagabbros of the Zanja del Tigre Complex present U-Pb LA-ICP-MS zircon ages of 1479 ± 4 and 1482 ± 6 Ma and tholeiitic gabbroic compositions. Geochemical and Sm-Nd isotopic data show similarities with LIP-related intracontinental mafic magmatism, suggesting a mixed magma source derived from depleted asthenosphere and fertile subcontinental lithospheric mantle contributions. Emplacement of the metagabbros was related to lithospheric extension in a continental rifting setting and, therefore, fertilization of the lithospheric mantle probably took place during older Paleoproterozoic subduction-related events. Coeval late Paleoproterozoic and early Mesoproterozoic magmatism is also recorded in the northern Nico Pérez Terrane of southernmost Brazil, and in basement inliers of the Kaoko Belt and the Angolan Shield (southwestern Congo Craton), thus suggesting a common evolution of these blocks prior to the Neoproterozoic

The annual recurrence risk model for tailored surveillance strategy in patients with cervical cancer

Purpose: Current guidelines for surveillance strategy in cervical cancer are rigid, recommending the same strategy for all survivors. The aim of this study was to develop a robust model allowing for individualised surveillance based on a patient's risk profile. Methods: Data of 4343 early-stage patients with cervical cancer treated between 2007 and 2016 were obtained from the international SCCAN (Surveillance in Cervical Cancer) consortium. The Cox proportional hazards model predicting disease-free survival (DFS) was developed and internally validated. The risk score, derived from regression coefficients of the model, stratified the cohort into significantly distinctive risk groups. On its basis, the annual recurrence risk model (ARRM) was calculated. Results: Five variables were included in the prognostic model: maximal pathologic tumour diameter; tumour histotype; grade; number of positive pelvic lymph nodes; and lymphovascular space invasion. Five risk groups significantly differing in prognosis were identified with a five-year DFS of 97.5%, 94.7%, 85.2% and 63.3% in increasing risk groups, whereas a two-year DFS in the highest risk group equalled 15.4%. Based on the ARRM, the annual recurrence risk in the lowest risk group was below 1% since the beginning of follow-up and declined below 1% at years three, four and >5 in the medium-risk groups. In the whole cohort, 26% of recurrences appeared at the first year of the follow-up, 48% by year two and 78% by year five. Conclusion: The ARRM represents a potent tool for tailoring the surveillance strategy in early-stage patients with cervical cancer based on the patient's risk status and respective annual recurrence risk. It can easily be used in routine clinical settings internationally