Photometric brown-dwarf classification. I. A method to identify and accurately classify large samples of brown dwarfs without spectroscopy

Aims. We present a method, named photo-type, to identify and accurately classify L and T dwarfs onto the standard spectral classification system using photometry alone. This enables the creation of large and deep homogeneous samples of these objects efficiently, without the need for spectroscopy. Methods. We created a catalogue of point sources with photometry in 8 bands, ranging from 0.75 to 4.6 microns, selected from an area of 3344 deg^2, by combining SDSS, UKIDSS LAS, and WISE data. Sources with 13.0 < J < 17.5, and Y - J > 0.8, were then classified by comparison against template colours of quasars, stars, and brown dwarfs. The L and T templates, spectral types L0 to T8, were created by identifying previously known sources with spectroscopic classifications, and fitting polynomial relations between colour and spectral type. Results. Of the 192 known L and T dwarfs with reliable photometry in the surveyed area and magnitude range, 189 are recovered by our selection and classification method. We have quantified the accuracy of the classification method both externally, with spectroscopy, and internally, by creating synthetic catalogues and accounting for the uncertainties. We find that, brighter than J = 17.5, photo-type classifications are accurate to one spectral sub-type, and are therefore competitive with spectroscopic classifications. The resultant catalogue of 1157 L and T dwarfs will be presented in a companion paper.Comment: 15 pages, 12 figures, Accepted for publication in A &

The Ultracool SpeXtroscopic Survey. I. Volume-Limited Spectroscopic Sample and Luminosity Function of M7−-L5 Ultracool Dwarfs

We present a volume-limited, spectroscopically-verified sample of M7$-$L5 ultracool dwarfs within 25\,pc. The sample contains 410 sources, of which $93\%$ have trigonometric distance measurements ($80\%$ from \textit{Gaia} DR2), and $81\%$ have low-resolution ($R\sim120$), near-infrared (NIR) spectroscopy. We also present an additional list of 60 sources which may be M7$-$L5 dwarfs within 25\,pc when distance or spectral type uncertainties are taken into account. The spectra provide NIR spectral and gravity classifications, and we use these to identify young sources, red and blue $J-K_S$ color outliers, and spectral binaries. We measure very low gravity and intermediate gravity fractions of $2.1^{+0.9}_{-0.8}\%$ and $7.8^{+1.7}_{-1.5}\%$, respectively; fractions of red and blue color outliers of $1.4^{+0.6}_{-0.5}$\% and $3.6^{+1.0}_{-0.9}$\%, respectively; and a spectral binary fraction of $1.6^{+0.5}_{-0.5}\%$. We present an updated luminosity function for M7$-$L5 dwarfs continuous across the hydrogen burning limit that agrees with previous studies. We estimate our completeness to range between $69-80\%$ when compared to an isotropic model. However, we find that the literature late-M sample is severely incomplete compared to L dwarfs, with completeness of $62^{+8}_{-7}\%$ and $83^{+10}_{-9}\%$, respectively. This incompleteness can be addressed with astrometric-based searches of ultracool dwarfs with \textit{Gaia} to identify objects previously missed by color- and magnitude-limited surveys.Comment: 71 pages, 27 figures, and 18 table

Ultracool SpeXtroscopic Survey. I. Volume-limited Spectroscopic Sample and Luminosity Function of M7−L5 Ultracool Dwarfs

We present a volume-limited, spectroscopically verified sample of M7−L5 ultracool dwarfs (UCDs) within 25 pc. The sample contains 410 sources, of which 93% have trigonometric distance measurements (80% from Gaia DR2) and 81% have low-resolution (R ~ 120), near-infrared (NIR) spectroscopy. We also present an additional list of 60 sources that may be M7−L5 dwarfs within 25 pc when distance or spectral-type uncertainties are taken into account. The spectra provide NIR spectral and gravity classifications, and we use these to identify young sources, red and blue J − K S color outliers, and spectral binaries. We measure very low gravity and intermediate-gravity fractions of 2.1^(+0.9)_(−0.8)% and 7.8^(+1.7)_(−1.5)%, respectively; fractions of red and blue color outliers of 1.4^(+0.6)_(−0.5)% and 3.6^(+1.0)_(−0.9)%, respectively; and a spectral binary fraction of 1.6^(+0.5)_(−0.5)%. We present an updated luminosity function for M7−L5 dwarfs continuous across the hydrogen-burning limit that agrees with previous studies. We estimate our completeness to range between 69% and 80% when compared to an isotropic model. However, we find that the literature late-M sample is severely incomplete compared to L dwarfs, with completeness of 62^(+8)_(−7)% and 83^(+10)_(−9)%, respectively. This incompleteness can be addressed with astrometric-based searches of UCDs with Gaia to identify objects previously missed by color- and magnitude-limited surveys

The AllWISE Motion Survey and the Quest for Cold Subdwarfs

The AllWISE processing pipeline has measured motions for all objects detected on Wide-field Infrared Survey Explorer (WISE) images taken between 2010 January and 2011 February. In this paper, we discuss new capabilities made to the software pipeline in order to make motion measurements possible, and we characterize the resulting data products for use by future researchers. Using a stringent set of selection criteria, we find 22,445 objects that have significant AllWISE motions, of which 3525 have motions that can be independently confirmed from earlier Two Micron All Sky Survey (2MASS) images, yet lack any published motions in SIMBAD. Another 58 sources lack 2MASS counterparts and are presented as motion candidates only. Limited spectroscopic follow-up of this list has already revealed eight new L subdwarfs. These may provide the first hints of a "subdwarf gap" at mid-L types that would indicate the break between the stellar and substellar populations at low metallicities (i.e., old ages). Another object in the motion list—WISEA J154045.67–510139.3—is a bright (J ≈ 9 mag) object of type M6; both the spectrophotometric distance and a crude preliminary parallax place it ~6 pc from the Sun. We also compare our list of motion objects to the recently published list of 762 WISE motion objects from Luhman. While these first large motion studies with WISE data have been very successful in revealing previously overlooked nearby dwarfs, both studies missed objects that the other found, demonstrating that many other nearby objects likely await discovery in the AllWISE data products

The Functions of Mediator in Candida albicans Support a Role in Shaping Species-Specific Gene Expression

The Mediator complex is an essential co-regulator of RNA polymerase II that is conserved throughout eukaryotes. Here we present the first study of Mediator in the pathogenic fungus Candida albicans. We focused on the Middle domain subunit Med31, the Head domain subunit Med20, and Srb9/Med13 from the Kinase domain. The C. albicans Mediator shares some roles with model yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe, such as functions in the response to certain stresses and the role of Med31 in the expression of genes regulated by the activator Ace2. The C. albicans Mediator also has additional roles in the transcription of genes associated with virulence, for example genes related to morphogenesis and gene families enriched in pathogens, such as the ALS adhesins. Consistently, Med31, Med20, and Srb9/Med13 contribute to key virulence attributes of C. albicans, filamentation, and biofilm formation; and ALS1 is a biologically relevant target of Med31 for development of biofilms. Furthermore, Med31 affects virulence of C. albicans in the worm infection model. We present evidence that the roles of Med31 and Srb9/Med13 in the expression of the genes encoding cell wall adhesins are different between S. cerevisiae and C. albicans: they are repressors of the FLO genes in S. cerevisiae and are activators of the ALS genes in C. albicans. This suggests that Mediator subunits regulate adhesion in a distinct manner between these two distantly related fungal species

Brown dwarfs and rare objects in UKIDSS

When brown dwarfs were first discovered two decades ago, they were introduced as the missing link between stars and giant planets. This led to the extension of the stellar classification sequence down to the planetary regime by introducing the spectral types L,T and Y. We are now in the era of brown dwarf science where large homogeneous samples can be produced, allowing us to learn about their physical properties in a statistically meaningful way. In this thesis we present a new method, dubbed photo-type, which makes the classification of L0-T8 dwarfs significantly faster as it only relies on already available multi-wavelength photometry. It is based on χ2 template fitting and can be adapted to use on any photometric data. photo-type classifies L and T dwarfs to an accuracy better than 1 spectral type, making it comparable to spectroscopy. This is tested by a range of different methods, ranging from simulations to spectroscopic follow up. By searching the SDSS+UKIDSS+WISE for L and T dwarfs with 13.0 < J < 17.5 we produce the largest homogeneous sample of these dwarfs to date. These 1157 L and T dwarfs are used to find peculiar objects and populations (e.g. blue/red outliers), L/T binaries, and benchmark systems (by crossmatching with a proper motion catalogue). It also allows us to calculate the best estimates of the space densities of L and T dwarfs to date. By following up several of the peculiar ultra cool dwarfs in our sample, we found a very young object (10Myrs), a number of dusty sources, and some that remain unexplained. Finally, we conducted a general search for rare objects in UKIDSS. Here we were interested in finding high redshift quasars, very cold white dwarfs or a yet unknown population by analysing objects with large χ2 values. While none of the above were found, we did find a moderate temperature H and He atmosphere white dwarf, a carbon star and some medium redshift quasars.Open Acces

Fuzeon® (étude de la cohorte de l'Hôpital Saint-Louis)

PARIS-BIUP (751062107) / SudocSudocFranceF

Hypoxia control to normalize pathologic angiogenesis: potential role for endothelial precursor cells and miRNAs regulation.

International audienceTumor microenvironment is a complex and highly dynamic milieu that provides very important clues on tumor development and progression mechanisms. Tumor-associated endothelial cells play a key role in stroma organization. They achieve tumor angiogenesis, a formation of tumor-associated (angiogenic) vessels mainly through sprouting from locally preexisting vessels and/or recruitment of bone marrow-derived endothelial progenitor cells. This process participates to supply nutritional support and oxygen to the growing tumor. Endothelial cells constitute the interface between circulating blood cells, tumor cells and the extracellular matrix, thereby controlling leukocyte recruitment, tumor cell behavior and metastasis formation. Hypoxia, a critical parameter of the tumor microenvironment, controls endothelial/tumor cell interactions and is the key to tumor angiogenesis development. Under hypoxic stress, tumor cells produce factors that promote angiogenesis, vasculogenesis, tumor cell motility, metastasis and cancer stem cell selection. Targeting tumor vessels is a therapeutic strategy that has lately been fast evolving from antiangiogenesis to vessel normalization as discussed in this review. We shall focus on the pivotal role of endothelial cells within the tumor microenvironment, the specific features and the part played by circulating endothelial precursors cells. Attention is stressed on their recruitment to the tumor site and their role in tumor angiogenesis where they are submitted to miRNAs-mediated de/regulation. Here the compensation of the tumor deregulated angiogenic miRNAs - angiomiRs - is emphasized as a potential therapeutic approach. The strategy is to over express anti-angiomiRs in the tumor angiogenesis site upon selective delivery by precursor endothelial cells as miRs carriers

The Ultracool SpeXtroscopic Survey. I. Volume-Limited Spectroscopic Sample and Luminosity Function of M7−-L5 Ultracool Dwarfs

We present a volume-limited, spectroscopically-verified sample of M7$-$L5 ultracool dwarfs within 25\,pc. The sample contains 410 sources, of which $93\%$ have trigonometric distance measurements ($80\%$ from \textit{Gaia} DR2), and $81\%$ have low-resolution ($R\sim120$), near- infrared (NIR) spectroscopy. We also present an additional list of 60 sources which may be M7$-$L5 dwarfs within 25\,pc when distance or spectral type uncertainties are taken into account. The spectra provide NIR spectral and gravity classifications, and we use these to identify young sources, red and blue $J-K_S$ color outliers, and spectral binaries. We measure very low gravity and intermediate gravity fractions of $2.1^{+0.9}_{-0.8}\%$ and $7.8^{+1.7}_{-1.5}\%$, respectively; fractions of red and blue color outliers of $1.4^{+0.6}_{-0.5}$\% and $3.6^{+1.0}_{-0.9}$\%, respectively; and a spectral binary fraction of $1.6^{+0.5}_{-0.5}\%$. We present an updated luminosity function for M7$-$L5 dwarfs continuous across the hydrogen burning limit that agrees with previous studies. We estimate our completeness to range between $69-80\%$ when compared to an isotropic model. However, we find that the literature late-M sample is severely incomplete compared to L dwarfs, with completeness of $62^{+8}_{-7}\%$ and $83^{+10}_{-9}\%$, respectively. This incompleteness can be addressed with astrometric- based searches of ultracool dwarfs with \textit{Gaia} to identify objects previously missed by color- and magnitude-limited surveys