Observation of a Complex Solar Wind Reconnection Exhaust from Spacecraft Separated by over 1800 R E

We analyze Wind, ACE, and STEREO (ST-A and ST-B) plasma and magnetic field data in the vicinity of the heliospheric current sheet (HCS) crossed by all spacecraft between 22:15 UT on 31 March and 01:25 UT on 1 April 2007 corresponding to its observation at ST-A and ST-B, which were separated by over 1800 R E (or over 1200 R E across the Sun – Earth line). Although only Wind and ACE provided good ion flow data in accord with a solar wind magnetic reconnection exhaust at the HCS, the magnetic field bifurcation typical of such exhausts was clearly observed at all spacecraft. They also all observed unambiguous strahl mixing within the exhaust, consistent with the sunward flow deflection observed at Wind and ACE and thus with the formation of closed magnetic field lines within the exhaust with both ends attached to the Sun. The strong dawnward flow deflection in the exhaust is consistent with the exhaust and X-line orientations obtained from minimum variance analysis at each spacecraft so that the X-line is almost along the GSE Z-axis and duskward of all the spacecraft. The observation of strahl mixing in extended and intermittent layers outside the exhaust by ST-A and ST-B is consistent with the formation of electron separatrix layers surrounding the exhaust. This event also provides further evidence that balanced parallel and antiparallel suprathermal electron fluxes are not a necessary condition for identification of closed field lines in the solar wind. In the present case the origin of the imbalance simply is the mixing of strahls of substantially different strengths from a different solar source each side of the HCS. The inferred exhaust orientations and distances of each spacecraft relative to the X-line show that the exhaust was likely nonplanar, following the Parker spiral orientation. Finally, the separatrix layers and exhausts properties at each spacecraft suggest that the magnetic reconnection X-line location and/or reconnection rate were variable in both space and time at such large scales

Formulation and in vitro evaluation of mucoadhesive controlled release matrix tablets of flurbiprofen using response surface methodology

The objective of the current study was to formulate mucoadhesive controlled release matrix tablets of flurbiprofen and to optimize its drug release profile and bioadhesion using response surface methodology. Tablets were prepared via a direct compression technique and evaluated for in vitro dissolution parameters and bioadhesive strength. A central composite design for two factors at five levels each was employed for the study. Carbopol 934 and sodium carboxymethylcellulose were taken as independent variables. Fourier transform infrared (FTIR) spectroscopy studies were performed to observe the stability of the drug during direct compression and to check for a drug-polymer interaction. Various kinetic models were applied to evaluate drug release from the polymers. Contour and response surface plots were also drawn to portray the relationship between the independent and response variables. Mucoadhesive tablets of flurbiprofen exhibited non-Fickian drug release kinetics extending towards zero-order, with some formulations (F3, F8, and F9) reaching super case II transport, as the value of the release rate exponent (n) varied between 0.584 and 1.104. Polynomial mathematical models, generated for various response variables, were found to be statistically significant (P<0.05). The study also helped to find the drug's optimum formulation with excellent bioadhesive strength. Suitable combinations of two polymers provided adequate release profile, while carbopol 934 produced more bioadhesion