499 research outputs found
Fuels and Burners for Domestic Heating
Discusses fuels and burners for domestic heating, including hand-fired coal or coke, automatic coal stoker, gas-fired heaters, oil burners. INlcudes table of comparative fuel costs
Options for informal environmental management : the agricultural industry highlighted
The original article can be found at: http://www3.interscience.wiley.com Copyright John Wiley & Sons, Ltd and ERP Environment.Discussions are frequently found in the environmental press regarding the possible advantages to an organisation should they implement a formal environmental management system such as BS 7750, ISO 14001 and the EC Eco-Management and Audit Scheme (EMAS). It is also widely recognised that these formal systems, although theoretically applicable to all, are often seen by many organisations as being too unwieldy, too prescriptive, frequently too expensive and often too public. However, there are many alternative options available to organisations who do not wish to commit themselves to a formal accredited system. This paper discusses the various options currently in use for informal environmental management in agriculture with particular reference to a computerised system being developed at the University of Hertfordshire. Application examples are taken from the agricultural industry.Peer reviewe
Salvage of ribose from uridine or RNA supports glycolysis in nutrient-limited conditions.
Glucose is vital for life, serving as both a source of energy and carbon building block for growth. When glucose is limiting, alternative nutrients must be harnessed. To identify mechanisms by which cells can tolerate complete loss of glucose, we performed nutrient-sensitized genome-wide genetic screens and a PRISM growth assay across 482 cancer cell lines. We report that catabolism of uridine from the medium enables the growth of cells in the complete absence of glucose. While previous studies have shown that uridine can be salvaged to support pyrimidine synthesis in the setting of mitochondrial oxidative phosphorylation deficiency <sup>1</sup> , our work demonstrates that the ribose moiety of uridine or RNA can be salvaged to fulfil energy requirements via a pathway based on: (1) the phosphorylytic cleavage of uridine by uridine phosphorylase UPP1/UPP2 into uracil and ribose-1-phosphate (R1P), (2) the conversion of uridine-derived R1P into fructose-6-P and glyceraldehyde-3-P by the non-oxidative branch of the pentose phosphate pathway and (3) their glycolytic utilization to fuel ATP production, biosynthesis and gluconeogenesis. Capacity for glycolysis from uridine-derived ribose appears widespread, and we confirm its activity in cancer lineages, primary macrophages and mice in vivo. An interesting property of this pathway is that R1P enters downstream of the initial, highly regulated steps of glucose transport and upper glycolysis. We anticipate that 'uridine bypass' of upper glycolysis could be important in the context of disease and even exploited for therapeutic purposes
The risk of cardiac failure following metal-on-metal hip arthroplasty
Aims
The aim of this study was to determine whether patients with metal-on-metal (MoM)
arthroplasties of the hip have an increased risk of cardiac failure compared with those with
alternative types of arthroplasties (non-MoM).
Patients and Methods
A linkage study between the National Joint Registry, Hospital Episodes Statistics and records
of the Office for National Statistics on deaths was undertaken. Patients who underwent
elective total hip arthroplasty between January 2003 and December 2014 with no past history
of cardiac failure were included and stratified as having either a MoM (n = 53 529) or a nonMoM
(n = 482 247) arthroplasty. The primary outcome measure was the time to an
admission to hospital for cardiac failure or death. Analysis was carried out using data from
all patients and from those matched by propensity score.
Results
The risk of cardiac failure was lower in the MoM cohort compared with the non-MoM cohort
(adjusted hazard ratio (aHR) 0.901; 95% confidence interval (CI) 0.853 to 0.953). The risk of
cardiac failure was similar following matching (aHR 0.909; 95% CI 0.838 to 0.987) and the
findings were consistent in subgroup analysis.
Conclusion
The risk of cardiac failure following total hip arthroplasty was not increased in those in
whom MoM implants were used, compared with those in whom other types of prostheses
were used, in the first seven years after surgery.
Cite this article: Bone Joint J 2018;100-B:20–
Reconstruction of Objects by Direct Demodulation
High resolution reconstruction of complicated objects from incomplete and
noisy data can be achieved by solving modulation equations iteratively under
physical constraints. This direct demodulation method is a powerful technique
for dealing with inverse problem in general case. Spectral and image
restorations and computerized tomography are only particular cases of general
demodulation. It is possible to reconstruct an object in higher dimensional
space from observations by a simple lower dimensional instrument through direct
demodulation. Our simulations show that wide field and high resolution images
of space hard X-rays and soft gamma rays can be obtained by a collimated
non-position-sensitive detector without coded aperture masks.Comment: 11 pages, 6 figure
Micro-Ethical Decision Making Among Baccalaureate Nursing Students: A Qualitative Investigation
Nursing students frequently encounter micro-ethical nursing practice problems during their clinical experience. The purpose of this study was to understand the lived experiences of senior-level baccalaureate students faced with making micro-ethical clinical decisions in practice settings. A descriptive qualitative design was used, and five central themes emerged. A dominant finding was the experience of unapplied and forgotten ethics education revealing a mismatch between what faculty perceived was taught and students’ experiences of that education. When faced with micro-ethical decisions, participants trusted and deferred to staff nurse recommendations, even if the advice contradicted best-practice standards. Contextual naivete was brought out of concealment, contributing to the experience of moral disequilibrium (i.e., students felt conflicted about what they learned in school as best practice and what they observed being role modeled in the clinical environment). This study resulted in theory-guided implications for nursing education and recommendations for future study
The effects of an experimental programme to support students’ autonomy on the overt behaviours of physical education teachers
Although the benefits of autonomy supportive behaviours are now well established in the literature, very few studies have attempted to train teachers to offer a greater autonomy support to their students. In fact, none of these studies has been carried out in physical education (PE). The purpose of this study is to test the effects of an autonomy-supportive training on overt behaviours of teaching among PE teachers. The experimental group included two PE teachers who were first educated on the benefits of an autonomy supportive style and then followed an individualised guidance programme during the 8 lessons of a teaching cycle. Their behaviours were observed and rated along 3 categories (i.e., autonomy supportive, neutral and controlling) and were subsequently compared to those of three teachers who formed the control condition. The results showed that teachers in the experimental group used more autonomy supportive and neutral behaviours than those in the control group, but no difference emerged in relation to controlling behaviours. We discuss the implications for schools of our findings
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