Thirty Meter Telescope Site Testing I: Overview

As part of the conceptual and preliminary design processes of the Thirty Meter Telescope (TMT), the TMT site testing team has spent the last five years measuring the atmospheric properties of five candidate mountains in North and South America with an unprecedented array of instrumentation. The site testing period was preceded by several years of analyses selecting the five candidates, Cerros Tolar, Armazones and Tolonchar in northern Chile; San Pedro Martir in Baja California, Mexico and the 13 North (13N) site on Mauna Kea, Hawaii. Site testing was concluded by the selection of two remaining sites for further consideration, Armazones and Mauna Kea 13N. It showed that all five candidates are excellent sites for an extremely large astronomical observatory and that none of the sites stands out as the obvious and only logical choice based on its combined properties. This is the first article in a series discussing the TMT site testing project.Comment: Accepted for publication in PASP, April 2009 issu

Correlates of Christian Religious Identification and Deidentification Among Sexual and Gender Minorities: A U.S. Probability Sample

Using a U.S. nationally representative sample of 1,529 sexual and gender minorities (SGMs), we examined the demographic and developmental correlates of Christian religious deidentification. We found that SGMs who were older, Black, cisgender men, and/or lived in the American South were more likely to identify as Christian in adulthood, relative to other SGMs. Those who were never Christian reported being more out to family and friends at earlier ages than those who were raised Christian. SGMs who were raised Christian, but did not identify as Christian in adulthood reported, more adverse childhood experiences and bullying than other SGMs. Sexual minorities who identified as Christian in adulthood reported more internalized homophobia in adulthood than other sexual minorities. Finally, sexual minorities who were raised Christian, regardless of their adulthood religious identification, reported experiencing more stigma than sexual minorities who were not raised Christian. No differences were noted in measures of adulthood resilience or health. Taken together, results indicate that identifying as Christian—in childhood and/or adulthood—is associated with greater experiences of stigma and stress than not identifying as Christian in adulthood

An examination of in-season external training load in semi-professional soccer players: considerations of one and two match weekly microcycles

The aim of the present study was to firstly, quantify the external training load (TL) of semi-professional soccer players during an annual season and secondly, to examine the influence of one (1MW) and two (2MW) match weekly microcycles. Data were collected from 24 semi-professional outfield soccer players during the 2018-2019 annual season using micro-electromechanical system (MEMS) devices for the following variables: Training duration (min), total distance (TD), Player Load (PL), high speed running (HSR) distance (5.5-7.0 m/s), and acceleration (ACC) efforts (>2 m/s2). Training sessions were defined as days before match day (i.e. MD minus), with match weeks broken down as either 1MW or 2MW. Data revealed higher TD, PL, and HSR distance on MD and MD-5 when compared to all other MD codes. MD-4 displayed significantly higher values compared to MD-1 (mean differences (Mdiff): TD: 785 ± 158 m; PL: 29 ± 9 au; HSR: 192 ± 63 m; ACC: 15 ± 3 #) and MD-2 (Mdiff: TD: 279 ± 137 m; HSR: 127 ± 54 m). During 2MW scenarios, both TD (Mdiff: 685 ± 328 m) and PL (Mdiff: 33 ± 14 au) were higher on MD-1 when compared to 1MW. However, lower values were observed for duration and HSR on MD-2 and MD-4 during 2MW compared to 1MW scenarios. These data suggest that there appears to be a progressive reduction in TD, PL, HSR and ACC leading into competitive matches based on MD- analysis. However, some variability exists in TL prescription as a result of different MW scenarios (i.e. 1MW vs. 2MW)

A Large Outbreak of Hepatitis E Among a Displaced Population in Darfur, Sudan, 2004: The Role of Water Treatment Methods.

BACKGROUND: The conflict in Darfur, Sudan, was responsible for the displacement of 1.8 million civilians. We investigated a large outbreak of hepatitis E virus (HEV) infection in Mornay camp (78,800 inhabitants) in western Darfur. METHODS: To describe the outbreak, we used clinical and demographic information from cases recorded at the camp between 26 July and 31 December 2004. We conducted a case-cohort study and a retrospective cohort study to identify risk factors for clinical and asymptomatic hepatitis E, respectively. We collected stool and serum samples from animals and performed a bacteriological analysis of water samples. Human samples were tested for immunoglobulin G and immunoglobulin M antibody to HEV (for serum samples) and for amplification of the HEV genome (for serum and stool samples). RESULTS: In 6 months, 2621 hepatitis E cases were recorded (attack rate, 3.3%), with a case-fatality rate of 1.7% (45 deaths, 19 of which involved were pregnant women). Risk factors for clinical HEV infection included age of 15-45 years (odds ratio, 2.13; 95% confidence interval, 1.02-4.46) and drinking chlorinated surface water (odds ratio, 2.49; 95% confidence interval, 1.22-5.08). Both factors were also suggestive of increased risk for asymptomatic HEV infection, although this was not found to be statistically significant. HEV RNA was positively identified in serum samples obtained from 2 donkeys. No bacteria were identified from any sample of chlorinated water tested. CONCLUSIONS: Current recommendations to ensure a safe water supply may have been insufficient to inactivate HEV and control this epidemic. This research highlights the need to evaluate current water treatment methods and to identify alternative solutions adapted to complex emergencies

A case of acute myeloid leukemia with promyelocytic features characterized by expression of a novel RARG-CPSF6 fusion

Key Points Novel RARG-CPSF6 fusion in an AML case with promyelocytic features and no evidence of PML-RARA or X-RARA fusion. Gene fusions involving RARG can initiate AML with promyelocytic morphological features.</jats:p