Concurrent Hypofractionated Radiotherapy and 5-Fluorouracil for Advanced Sarcomas of the Bone

Purpose. 5-Fluorouracil (5-FU) has shown radiosensitizing properties in vitro. This paper reports the effects of radiotherapy and concomitant intravenous 5-FU radiosensitization in the treatment of advanced bone sarcomas

Issues with n-type Dopants in Germanium

The last decade has seen considerable experimental and theoretical work towards the use of germanium for high-speed low-power electronics. Despite the demonstration of high performance p-channel Ge transistors in planar and non-planar device technology, fabrication of n-channel Ge transistors faces a number of scientific and technological challenges, which hinder the development of CMOS logic circuits based entirely on Ge. Major challenge constitutes the control of fast n-type dopant (out-/in-)diffusion in Ge, which prevents the formation of ultra-shallow and highly activated n+/p junctions necessary for n-channel Ge MOSFET’s enhanced performance. The paper focuses on parameters affecting n-type dopant diffusion in Ge and the attempts to suppress it, with particular emphasis on the action of nitrogen as phosphorous diffusion blocker

The top ten priorities in adults living with type 1 diabetes in Ireland and the United Kingdom – a James Lind Alliance Priority Setting Partnership

Aims: to undertake a Priority Setting Partnership (PSP), identifying the most important unanswered questions in type 1 diabetes in Ireland and the United Kingdom and to compare these to priorities identified in a 2011 PSP.Methods: a steering committee (including eight individuals with lived experience/charity representatives and six clinicians) designed a survey which asked stakeholders to list three questions about type 1 diabetes. This was disseminated through social media, direct email contact, and printed posters. Following analysis, a second survey asked participants to rank these priorities in order of importance. The top questions were then carried forward to an online, 2 days final workshop where the final top 10 were ranked.Results: there were 1050 responses (64% female, 78% adults living with type 1 diabetes, 9% healthcare professionals, 9% family members) to the first survey and 2937 individual questions were submitted. Sixty-five summary questions were submitted into a second survey, completed by 497 individuals (76% adults living with type 1 diabetes, 9% healthcare professionals, and 11% family members). Nineteen questions from the interim survey progressed to a final workshop, which identified the top 10 priorities through group discussion. As in 2011, there was emphasis on psychological health, diabetes-related complications, and hypoglycaemia. New themes prioritised included artificial intelligence and women's health.Conclusions: the research priorities, which have been identified using a robust and proven methodology, highlight the key concerns of those living with type 1 diabetes, their families and representatives, as well as clinicians in Ireland and the UK.<br/