Pharmacological screening of substances with cardioprotective effect in the group of 3-oxypyridine derivatives

Research objectives: To study the anti-hypoxic and cardioprotective effects of 3-oxypyridine derivatives. The search for compounds with an antihypoxic effect was carried out on blood leukocytes of rats in in vitr

Antiamnestic effect of new nicotinic acid derivatives

The search for new drugs for the prevention and treatment of vascular cognitive disorders continues to be a relevant task of pharmacology. In this regard, the aim of this work is to study the antiamnestic effect of five new nicotinic acid derivatives in comparison with the well-known drug mexidol (ethylmethylhydroxypyridine succinate) in animal

Antitumor activity of the novel pyridine derivative

The study aim was to explore a toxicological property and antitumor action of the novel pyridine derivative LHT-17-19 in cell culture and on experimental models of lung cancer in mic

Некоторые особенности отечественных лекарственных форм ß2-агонисто

The data about 3 different broncholytic salbutamol-derived agents were considered in this article. Some peculiarities of Russian ß2-agonists in comparisson with forein analogs were observed. The results of preclinical and pharmacokinetic surveys of Russian Salbutamol and its perspective derivates, and features and advantages of several devices for inhalation of dry powders were presented. It was shown that properties and clinical efficacy of Russian ß2-agonists are comparable are the best forein analogs.В статье представлены данные о трех различных лекарственных формах бронхолитическ их препаратов на о снов е сальбутамола и его производных. Рассмотрены вопросы, касающиеся особенностей отечественных лекарственных форм в отличие от зарубежных аналогов. Представлены результаты доклинических и фармакокинетических исследований отечественного сальбутамола и его перспективных производных, а также особенности и преимущества различных устройств для ингаляций лекарственных форм в виде сухого порошка. Показано, что по своим характеристикам и клинической эффективности отечественные лекарственные формы ß2 –агонистов адренергических рецепторов не уступают лучшим зарубежным аналогам этой группы

BRONCHODILATOR AND TOCOLYTIC FEATURES OF β₂-ADRENOCEPTOR AGONISTS

The issues (aspects) of bronchodilator and tocolytic actions of β₂-adrenoceptor agonists are reviewed. The data on short-acting and new long-acting β₂-agonists are presented. It is marked that it is necessary to use long-acting β₂-agonists and glucocorticosteroids concomitantly. Examples of clinical efficacy of locally produced β₂-adrenoceptor agonist salbutamol hemisuccinate in various dosage forms used as a bronchodilator for treatment of bronchopulmonary diseases, and also as a tocolytic for habitual noncarrying of pregnancy are given

Pharmacological screening of substances with cardioprotective effect in the group of 3-oxypyridine derivatives

Research objectives: To study the anti-hypoxic and cardioprotective effects of 3-oxypyridine derivatives. The search for compounds with an antihypoxic effect was carried out on blood leukocytes of rats in in vitr

DRUGS DEVELOPED AT «ARC BASS» WITH M.D. MASHKOVSKII LEAD (REVIEW)

Introduction. There are presented data on drugs development with M.D. Mashkovskii lead. There are given materials on drugs belonging to important pharmacotherapeutic groups of drugs such as generic and original drugs. Original syntheses of famous generic drugs and improved industrial technologies have been developed. The attention is paid to high quality of produced drugs. More than 200 new molecules were synthesized while developing original structures of nitrobenzamide derivatives. The studies of pharmacological and toxicological characteristics have helped to choose and create original antiarrhythmic nibentan and niferidyl. The drugs are registered in the Ministry of Healthcare of the Russian Federation and included in essential drugs list.Text. VNIKHFI branch called today VNC BAV founded in 1966. M.D. Mashkovskii offered that creation to expand scientific and experimental base of drugs development. It continues to research and develop new drugs including syntheses of original molecules, developing of industrial technology, and preclinical research of pharmacological activities, drug safety, and toxicology. Original synthesis schemes are described shortly in the article. Industrial technologies of pharmacopoeial substance synthesis are developed out of these schemes such as γ-butyric acid, dopamine, analgin for injection, and original drugs nibentan – ((RS) N-[5-(diethylamino)-1-phenylpentyl]-4-nitrobenzamide hydrochloride), niferidyl – N-1-[(4-fluorophenyl)- 2-(1-ethyl-4-piperidyl)ethyl]-4-nitrobenzamide hydrochloride. The release of developed drugs to the national industrial production is specially noted.Conclusion. M.D. Mashkovskii always supported national drugs development by submitting valuable offers, paying constant attention to scientific research, quality of drugs, and drugs production in industrial quantities for securing national healthcare with national drugs