83 research outputs found
(2E)-2-[(2-Hydroxy-4-methoxyphenyl)(phenyl)methylidene]-N-phenylhydrazinecarboxamide dimethylformamide monosolvate
The title compound, C21H19N3O3·C3H7NO, adopts an E conformation with respect to the azomethine bond and crystallizes in the amide form. The dihedral angle between the rings lined to the C=N bond is 88.60 (12)°. The dimethylformamide solvent molecule is disordered over two orientations with site occupancies of 0.684 (3) and 0.316 (3). The two N atoms of the hydrazinecarboxamide group are involved in intermolecular N—H⋯O hydrogen bonds in which the dimethylformamide O atom acts as acceptor. The structure also features π–π interactions, with a centroid–centroid distance of 3.6561 (13) Å. Classical and non-classical intramolecular O—H⋯N and C—H⋯O hydrogen bonds are also present
Crystal structure of 8-[7, 8-bis(4-chlorobenzoyl)-7H-cyclopenta[a]acenaphthylen-9-yl]naphthalene-1-carboxylic acid
JPJ and CK are obliged to Dr S. Prathapan for introducing them to the field of domino reactions. SAIF (STIC) CUSAT, Kochi, India, provided spectroscopic, analytical and single crystal X-ray diffraction data.Peer reviewedPublisher PD
Bis{μ-2-[bis(pyridin-2-yl)methylidene]hydrazinecarbothioamidato}bis[bromidocopper(II)] methanol disolvate
In the centrosymmetric binuclear title compound, [Cu2Br2(C12H10N5S)2]·2CH3OH, the CuII ion adopts a slightly distorted square-pyramidal coordination geometry. The hydrazine carbothioamide moiety and one of the pyridyl rings together adopt an almost planar arrangement, with a maximum deviation of 0.052 (4) Å for the C atom of the thiourea moiety. There are two molecules of methanol solvent per complex in the asymmetric unit. The nonconventional intramolecular C—H⋯Br hydrogen bonds make the molecule more rigid, whereas the conventional N—H⋯N and O—H⋯Br intermolecular hydrogen-bonding interactions, supported with N—H⋯π interactions, establish a supramolecular linkage among the molecules in the crystal. An intermolecular C—H⋯O interaction is also present
A Study on Hydrogen Peroxide Scavenging Activity and Ferric Reducing Ability of Simple Coumarins
Coumarin compounds are δ-lactones where α-pyrone ring is fused with benzene ring. Coumarins are widely distributed in the plant kingdom as well as they are very important in synthetic organic chemistry. Coumarins have great interest because of their abundance in nature and diverse pharmacological activities including antibacterial, antiviral, antipyretic, and anticoagulant, antioxidant, anti-inflammatory and anticancer. This study focused on synthesizing different simple Coumarins and studying their antioxidant activity. Four simple Coumarins (Coumarin (C1), 4-hydroxy coumarin (C2), 7-hydroxy coumarin (C3) and 7-hydoxy-4-methyl coumarin (C4)) were synthesized by using standard methods and were characterized by using UV, IR, 1H and 13C NMR spectra. Antioxidant activity of the simple Coumarins was studied by using standard FRAP assay and Hydrogen peroxide assay and expressed as FRAP value (mmol Fe2+/g) and IC50 value (mg/dm-3) respectively. Ascorbic acid was used as standard. All synthesized simple Coumarins showed both antioxidant activities. Hydroxyl Coumarins (C2, C3 and C4) showed higher activities in both cases than C1. Among the hydroxyl Coumarins C3 showed highest hydrogen peroxide scavenging activity and Ferric reducing capacity too. Antioxidant power of the tested simple Coumarins in decreasing order was C3, C2, C4 and C1 in both cases. But the hydrogen peroxide scavenging activity and Ferric reducing capacity of the all synthesized simple Coumarins were lower when compared to standard ascorbic acid
2-(3-Ethoxy-2-hydroxybenzylidene)-N-phenylhydrazinecarboxamide
The title compound, C16H17N3O3, exists in the E configuration with respect to the azomethine double bond. The molecule is close to planar, with a dihedral angle of 6.7 (1)° between the aromatic rings. The phenolic O atom functions as donor and acceptor by forming intramolecular O—H⋯O and intermolecular N—H⋯O hydrogen bonds, respectively. Two-dimensional packing is fashioned through an intermolecular hydrogen bonding network in an offset manner
N′-[(E)-Furan-2-ylmethylidene]pyridine-3-carbohydrazide
The title compound, C11H9N3O2, exists in the E conformation with respect to the azomethane C=N bond, and has the keto form. There are two independent molecules in the asymmetric unit and each of these features a slight slanting of the pyridine and furan rings, which form a dihedral angle of 14.96 (10)° in one of the molecules and 5.53 (10)° in the other. The crystal structure is stabilized by N—H⋯O and N—H⋯N hydrogen bonds, weak C—H⋯O and C—H⋯N hydrogen bonds and C—H⋯π interactions and π–π interactions [shortest centroid–centroid distance = 3.7864 (15) Å]
(E)-2-(4-Benzyloxy-2-hydroxybenzylidene)-N-phenylhydrazinecarbothioamide
The title compound, C21H19N3O2S, exists in the thione form. The configuration about the C=N bond is E. The hydrazinecarbothioamide unit adopts an almost planar arrangement, with maximum deviations of 0.016 (3) and −0.016 (2) Å for the two thiourea N atoms. An intramolecular O—H⋯N hydrogen bond occurs. Weak intermolecular N—H⋯S, C—H⋯O and C—H⋯π interactions are observed in the crystal structure
N′-[(E)-4-Benzyloxy-2-hydroxybenzylidene]-4-nitrobenzohydrazide monohydrate
The title compound, C21H17N3O5·H2O, exists in the keto form with an E conformation with respect to the azomethine double bond. The twist angles between the aromatic rings are in the range 4.67 (10)–17.54 (10)°. A water molecule of solvation is present in the lattice. A conventional intramolecular O—H⋯N hydrogen bond increases the rigidity of the molecule. Intermolecular O—H⋯O, N—H⋯O and C—H⋯O hydrogen-bonding interactions establish a supramolecular linkage among the molecules in the crystal structure. There are also C—H⋯π interactions present
(Z)-N,N-Dimethyl-2-[phenyl(pyridin-2-yl)methylidene]hydrazinecarbothioamide
The title compound, C15H16N4S, exists in the Z conformation with the thionyl S atom lying cis to the azomethine N atom. The shortening of the N—N distance [1.3697 (17) Å] is due to extensive delocalization with the pyridine ring. The hydrazine–carbothioamide unit is almost planar, with a maximum deviation of 0.013 (2) Å for the amide N atom. The stability of this conformation is favoured by the formation of an intramolecular N—H⋯N hydrogen bond. The packing of the molecules involves no classical intermolecular hydrogen-bonding interactions; however, a C—H⋯π interaction occurs
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