Bio-material polylactic acid/poly(butylene adipate-co-terephthalate) blend developed for extrusion- based additive manufacturing

Bio-material polylactic acid and poly(butylene adipate-co-terephthalate) were blended to achieve increased ductility of the blend. Cloisite was added to improve the stiffness of the blend. The blends were made into filament suitable for extrusion-based additive manufacturing. Melt flow index of the filament and mechanical properties of the printed bars were tested. Preliminary results showed that the melt flow index increases significantly with cloisite and the modulus of polylactic acid/poly(butylene adipate-co-terephthalate) improved slightly. The notched impact strength of the blend increased with increasing content of cloisite, and it increased significantly after annealing, especially for blends without cloisite

PELECEHAN SEKSUAL DALAM TIKTOK ‘PERSALINAN’: ANALISIS SEMIOTIKA ROLAND BARTHES

Abstrak-Fenomena TikTok ‘persalinan’ membuat ketakutan dan keraguan tersendiri bagi kaum perempuan.  Hal ini dikarenakan viralnya konten TikTok yang berdurasi 15 detik mengenai pemeriksaan vagina saat persiapan persalinan yang dikecam sebagai pelecehan seksual. Tujuan penelitian ini untuk menganalisis tanda dan mengungkap makna dibalik tanda yang membentuk tudingan sebagai unsur pelecehan seksual.  Penelitian ini menggunakan pendekatan kualitatif dengan analisis semiotika tokoh Roland Barthes mengkaji  tigapeta tanda, yakni: makna denotatif, makna konotatif, dan mitos.  Hasil penelitian menunjukkan tanda denotatif berupa gerakan visual, verbal, dan audio sebagai  petanda.  Ekspresi-ekspresi yang ditimbulkan saat pemeriksaan vagina mengandung makna konotatif yang merepresentasikan  aktivitas-aktivitas seks menggunakan jari tangan sehingga membentuk mitos yang berpotensi hilangnya rasa kepercayaan perempuan Indonesia untuk ke dokter obgyn lelaki dan kekhawatiran tindakan yang memalukan saat persalinan. Kata kunci : pelecehan seksual, tiktok persalinan, semiotika roland barthes, representasi sek

PD-L1 ≥ 50% lung cancer refractory to PD-1 inhibition: The role of salvage chemo-immunotherapy combination

Novel treatment strategies incorporating PD-1/PD-L1 inhibitors in the first-line setting of advanced non-small-cell lung cancer (NSCLC) provided relevant improvements in survival outcomes. Among NSCLC patients with PD-L1 tumor proportion score ≥50%, identifying the ones to be addressed to pembrolizumab monotherapy or chemo-immunotherapy combinations is a matter of debate, taking into account the risks of overtreatment and toxicity. Here we report the clinical stories of four NSCLC patients with PD-L1 tumor proportion score ≥50% and good performance status, sharing high tumor burden including serosal involvement. After having rapidly progressed on first-line PD-1/PD-L1 inhibitors, they achieved major clinical and radiological response to pembrolizumab-chemotherapy combination. These cases prove the feasibility and effectiveness of salvage chemo-immunotherapy in pembrolizumab-refractory NSCLC patients

The impact of interactive augmented reality based education on the learning and remembering of empirical science lesson

Background and Objectives: Education plays a key role in human life. While the teaching of experimental sciences is one of the most important topics that should be accompanied by student's direct experience, in many cases, due to spatial, temporal, or cost-related constraints, it is based solely on traditional books and their one-dimensional media. With the spread of new technologies, there are new opportunities for existing teaching and learning methods that can transform the educational structure. Augmented Reality (AR) technology, as a novel paradigm, potentially adds a new feature to the range of traditional student books that not only adds multimedia elements, but also allows interactive engagement with the content of them. Augmented reality, as one of the ways of distance learning, by simulating the real world in the form of animation, virtual objects, three-dimensional images, sound and similar elements makes it possible for the user to interact with the with the experiments of a lesson virtually. This study aims to evaluate the effect of interactive augmented reality based education on the learning and remembering of the content of textbooks. Methods: An experimental study in the pre-test and post-test quasi-experimental framework was performed on two groups of 18 sixth grade elementary school students. For this purpose, two scenarios have been selected from student science book and implemented in an interactive augmented reality application. The control group was trained through traditional teaching method. On the other hand, in addition to the traditional teaching method, the experiment group’s training was reinforced with the AR application. Students' learning and remembering evaluation was carried out through two tests. The validity of tests confirmed by the teachers of science in Education District 2 of Tabriz and their reliability has been calculated through Kuder – Richardson Formula. Findings: The results of analysis of covariance (ANCOVA) showed a significant statistical difference between the control and experimental groups. Also, the learning and remembering in students who were trained in interactive augmented reality were more effective than the other group. Conclusion:  According to the results of the experiments, and the comparative review of the theoretical subjects, the use of augmented reality technology has been reported as a useful and effective supplemental tool for textbooks that can, beyond the spatial and temporal constraints, facilitate the training process. Also, the interaction in AR encourages learners to replace the active role with the passive one and to learn the topics with more mental participation. On the other hand, the possibility of repeating augmented reality scenarios in educational topics, regardless of spatial, temporal, and cost-realted constraints, allows users to fix bugs and ambiguities, which are other advantages of using this technology. Finally, by examining these capabilities and the ubiquity of mobile phones in today's world, we can predict the presence of virtual laboratories in mobile smartphones in the near future; which can be useful in deprived areas of the country as a replacement of the lack of minimum facilities.   ===================================================================================== COPYRIGHTS  ©2020 The author(s). This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, as long as the original authors and source are cited. No permission is required from the authors or the publishers.  ====================================================================================

Monitoring of multi-class pesticide residues in green grape and their potential risk for Egyptian consumer

Abstract: The residual concentrations of 100 pesticides in 32 fresh grape samples collected from local markets at eight Egyptian governorates during 2011' summer season were monitored based on QuEChERS extraction followed by analysis using liquid chromatography-tandem mass spectrometry (LC-MS/MS) and gas chromatographytandem mass spectrometry (GC-MS/MS). The potential health risks associated with the exposure to violated pesticides were estimated as well. Mean recoveries ranged between 71 and 96.3%, while the repeatability expressed as relative standard deviation (RSD) was < 19.8%. Limits of quantification (LOQ) was 0.01 mg kg -1 , which is equal or below the Maximum Residue Limits (MRLs). Of the analysed samples, 81.25% contained detectable residues, of which 21.88% exceeded their MRLs. Out of 35 pesticides that were detected in grape samples, carbendazim, acetamiprid, boscalid, λ-cyhalothrin, profenofos and pyraclostrobin were the most frequently pesticides detected. No residues of organochlorine pesticides and their metabolites were detected in any analysed samples. This study showed also that the estimated daily intake (EDI) of the violated pesticides by the Egyptian population through the consumption of grape did not exceed the toxicological acceptable level

An informed approach to the development of primary care pediatric firearm safety messages

BACKGROUND: Firearm ownership is prevalent in the US and many children spend time in areas where firearms are not stored safely. The AAP recommends firearm safety counseling at pediatric well-visits. METHODS: We developed and tested six contextual messages to promote safe firearm storage based on: absence of harm, collective appeal to understanding child behavior, pediatrician\u27s authority, evidence-based, fear appeal, and general safety considerations. One hundred four parents who keep firearms at home were recruited from Amazon Mechanical Turk Prime and viewed video messages and reported behavioral intentions and emotional reactions following each message. RESULTS: All six contextual messages were perceived as important and believable and increased parents\u27 intentions to follow safety advice provided, but also elicited negative emotions. The authority message elicited more negative emotions and resulted in lower intentions to follow safe storage advice. CONCLUSIONS: Including firearm messages with other child safety advice merits further evaluation. Authority messages should be avoided

Measurement of Losses in a Austoft Sugarcane Harvester Case 7000

IntroductionSugarcane is one of the strategic products of Khuzestan province, which is cultivated in 10 active agro-industrial sites and covers an area of about 110,000 hectares of irrigated farms in the province. Sugarcane harvesting, like most crops, is done by special sugarcane harvesters. Due to the life of machines and also the amount of heavy machine operations in each season of sugarcane harvest, the loss is inevitable. On the other hand, in Khuzestan province, due to lack of studies, there is little information in this area. Therefore, the aim of this study is to investigate the extent of losses during sugarcane harvesting operations, taking into account factors such as cultivars, age of sugarcane, and reaping speed of the Astaf 7000 model. The study will be conducted at the sugarcane agro-industrial site of Dehkhoda in 2021.Materials and MethodsThe experiment was conducted as a factorial split-plot design based on randomized complete blocks (RCBD) with three replications. The first factor included four levels of cultivars (IRC-12, CP48-103, CP 73-21, and CP69-1062), the second factor included three levels of harvest age (plant, Ratoon 1, Ratoon 2), and the third factor included three levels of speed (3, 5, and 7 km h-1). Sampling was carried out under the same and constant conditions with respect to soil moisture content, harvester operator, harvester characteristics, harvester settings, and crop density in each field.Results and DiscussionThe results of analysis of variance of the data obtained from measuring sugarcane losses showed that the effect of cultivar on yield, full-length sugarcane, chopped sugarcane and splinter sugarcane had a significant effect at a probability level of one percent. The effect of age had a significant effect on yield, full-length sugarcane, chopped sugarcane with a probability level of one percent, but had no significant effect on the amount of splinter sugarcane. The interaction between cultivar and age had a significant effect on yield, chopped sugarcane, and full-length sugarcane with a probability level of one percent and on splinter sugarcane with a probability level of five percent. The effect of machine speed had a significant effect on full-length sugarcane, chopped sugarcane and splinter sugarcane with a probability level of one percent, but had no significant effect on yield. The interaction of cultivar and machine speed had a significant effect on yield, full-length sugarcane, chopped sugarcane and splinter sugarcane with a probability level of one percent. The interaction effect of age and machine speed on yield had a significant effect on full-length sugarcane and splinter sugarcane with a probability level of one percent and on the amount of splinter sugarcane with a probability level of five but had no significant effect on yield. Also, the interaction of cultivar, age and machine speed had a significant effect on yield, full-length sugarcane and chopped sugarcane with a probability level of one percent, but had no significant effect on the amount of splinter sugarcane. The results showed that the highest yield in CP69-1062 variety was observed in the plant farm with average machine speed (144.33 tons per hectare). Also, the highest amount of sugarcane losses in cultivar CP48-103 in Raton II and with 7 km h-1 machine speed (3.32 tons per hectare), the highest amount of chopped sugarcane losses in cultivar CP48-103 in plant farm and with average speed (1.78 tons per hectare) was observed. According to the results under the interaction of cultivar and device speed, the highest amount of sugarcane losses in CP69-1062 cultivar and high speed (0.314 tons per hectare) as well as IRC-12 cultivar and high speed (0.308 tons in Hectares), and under the interaction of farm age and speed of the harvester, the highest amount of sugarcane losses was observed in Ratoon farm and the high speed of the harvester (0.300 tons per hectare).ConclusionTherefore, in order to reduce the amount of losses in sugarcane fields, it is recommended to use resistant and somewhat later cultivars for cultivation, because early cultivars are more fragile during harvest due to stem fragility and the rate of losses increases. Also, Harvester speed optimization reduces the amount of losses, and due to the increase in the rate of losses in reclaimed farms, it is recommended to create more resistant stem tissue by proper plant nutrition and more care to reduce the rate of losses in ratoon farms

3-Phase Rectifier System with very demanding dynamic load

This paper present a distributed power architecture for aerospace application with very restrictive specifications. Additionally, the rectifier switching frequency has to be synchronized with an external frequency clock to minimize the interference of the converter harmonics with the load. In order to protect the 3 phase generator against high load steps, an intermediate bus (based in a high capacitance) to provide energy to the loads during the high load steps is included. Prototypes of the rectifier and EMI filter are built and the energy control is validated

Aub and Ago3 Are Recruited to Nuage through Two Mechanisms to Form a Ping-Pong Complex Assembled by Krimper

In Drosophila, two Piwi proteins, Aubergine (Aub) and Argonaute-3 (Ago3), localize to perinuclear “nuage” granules and use guide piRNAs to target and destroy transposable element transcripts. We find that Aub and Ago3 are recruited to nuage by two different mechanisms. Aub requires a piRNA guide for nuage recruitment, indicating that its localization depends on recognition of RNA targets. Ago3 is recruited to nuage independently of a piRNA cargo and relies on interaction with Krimper, a stable component of nuage that is able to aggregate in the absence of other nuage proteins. We show that Krimper interacts directly with Aub and Ago3 to coordinate the assembly of the ping-pong piRNA processing (4P) complex. Symmetrical dimethylated arginines are required for Aub to interact with Krimper, but they are dispensable for Ago3 to bind Krimper. Our study reveals a multi-step process responsible for the assembly and function of nuage complexes in piRNA-guided transposon repression