ダイズ根粒菌の脱窒過程に関する研究

要約のみTohoku University南澤究課

Imagens do turismo: para uma etnografia das imagens dos lugares turísticos e do cartão postal

-O presente projeto de pesquisa busca pelo significado das imagens de lugares e seus atrativos turísticos. Através do que chamamos de uma etnografia das imagens dos lugares turísticos, buscamos pelos sentidos que são veiculados e comunicados em materiais midiáticos e ou fotografias feitas na cidade de Juiz de Fora. Além das imagens, também buscamos por narrativas, falas e discursos de atores sociais locais sobre o significado do atrativo turístico. Realiza-se, assim, um tipo de mapeamento da produção simbólica presente nas práticas, gestos e falas de sujeitos que vivem cotidianamente em determinadas localidades

Perfuração gastrointestinal relacionada a Granulomatose Eosinofílica com Poliangiíte pós-Covid-19 – um relato de caso

Introdução: A Granulomatose eosinofílica com poliangiíte (GEPA), anteriormente conhecida como Síndrome de Churg Strauss, é considerada uma doença rara e se caracteriza por uma vasculite necrotizante disseminada, associada com o anticorpo anticitoplasma do neutrófilo (ANCA)4,5. Ocorre infiltração eosinofílica, o qual pode acometer pulmões, coração, rins, tecido nervoso e trato gastrointestinal (TGI) 1, 2, 3 , e que o prognóstico varia de acordo com o sistema acometido 6. Relato do caso: Trata-se de paciente do sexo masculino, 58 anos, que deu entrada em pronto socorro com quadro de abdome perfurativo. O paciente possuía história de asma iniciada na vida adulta, além de internação recente por COVID-19. Os exames laboratoriais demonstravam eosinofilia importante (75% da contagem leucocitária), e o estudo anatomopatológico demonstrou enterite eosinofílica com focos de vasculite eosinofílica. Conclusão: A possibilidade de um diagnóstico de GEPA sempre deve suspeitado em pacientes que apresentam eosinofilia exuberante, principalmente quando associado com história de asma, polipose nasal e parestesias. Um diagnóstico precoce possibilita o início de uma abordagem terapêutica, o que gera significante melhora na qualidade de vida desses pacientes, bem como em seu prognóstico

COVID-19, FAKE NEWS E VACINAÇÃO: OS DESAFIOS ENFRENTADOS NA SAÚDE PÚBLICA

The Covid-19 pandemic caused the disease to spread rapidly across all continents and spread various positive and negative information, which circulated or circulated on the internet, presenting different content. The objective of this study is to inform the population about the Fake News approach and the spread of misinformation and the challenges that public health faces. Studies were carried out from secondary sources, through bibliographic research in scientific databases, in the time window from 2021 to 2023, with the most recent and compatible articles prevailing. Eleven complete and published articles were found, related to vaccination against Covid-19, Fake News associated with the vaccination process and the influence on the population's adherence to immunizations in the context of public health. The Covid-19 pandemic, which was characterized by the acute respiratory syndrome popularly known as SARS-CoV-2, which resulted in several deaths due to lack of vaccination and also generated the infodemic and misinformation pandemic, where society began to discredit science and credibility it had.continentes e propagou diversas informações positivas e negativas, que circulam ou circularam na internet apresentando conteúdos diversos. O Objetivo deste estudo é informar a população sobre a abordagem de Fake News e a propagação da desinformação e os desafios que saúde pública enfrenta. Foram realizados estudos a partir de fontes secundárias, por meio da pesquisa bibliográfica em bancos de dados científicos, na janela temporal de 2021 a 2023, prevalecendo os artigos mais recentes e compatível. Encontrou-se onze artigos completos e publicados, relacionados à vacinação contra a Covid-19, Fake News associadas ao processo vacinal e a influência na adesão da população aos imunizantes no contexto de saúde pública. A pandemia de Covid-19 que foi caracterizada pela síndrome respiratória aguda popularmente conhecida como SARS-CoV-2, que obtive diversas mortes por falta de vacinação e também gerou a pandemia da infodemia e desinformação, onde a sociedade começou a desacreditar nas ciências e na credibilidade que a mesma tinha

Impact of COVID-19 on cardiovascular testing in the United States versus the rest of the world

Objectives: This study sought to quantify and compare the decline in volumes of cardiovascular procedures between the United States and non-US institutions during the early phase of the coronavirus disease-2019 (COVID-19) pandemic. Background: The COVID-19 pandemic has disrupted the care of many non-COVID-19 illnesses. Reductions in diagnostic cardiovascular testing around the world have led to concerns over the implications of reduced testing for cardiovascular disease (CVD) morbidity and mortality. Methods: Data were submitted to the INCAPS-COVID (International Atomic Energy Agency Non-Invasive Cardiology Protocols Study of COVID-19), a multinational registry comprising 909 institutions in 108 countries (including 155 facilities in 40 U.S. states), assessing the impact of the COVID-19 pandemic on volumes of diagnostic cardiovascular procedures. Data were obtained for April 2020 and compared with volumes of baseline procedures from March 2019. We compared laboratory characteristics, practices, and procedure volumes between U.S. and non-U.S. facilities and between U.S. geographic regions and identified factors associated with volume reduction in the United States. Results: Reductions in the volumes of procedures in the United States were similar to those in non-U.S. facilities (68% vs. 63%, respectively; p = 0.237), although U.S. facilities reported greater reductions in invasive coronary angiography (69% vs. 53%, respectively; p < 0.001). Significantly more U.S. facilities reported increased use of telehealth and patient screening measures than non-U.S. facilities, such as temperature checks, symptom screenings, and COVID-19 testing. Reductions in volumes of procedures differed between U.S. regions, with larger declines observed in the Northeast (76%) and Midwest (74%) than in the South (62%) and West (44%). Prevalence of COVID-19, staff redeployments, outpatient centers, and urban centers were associated with greater reductions in volume in U.S. facilities in a multivariable analysis. Conclusions: We observed marked reductions in U.S. cardiovascular testing in the early phase of the pandemic and significant variability between U.S. regions. The association between reductions of volumes and COVID-19 prevalence in the United States highlighted the need for proactive efforts to maintain access to cardiovascular testing in areas most affected by outbreaks of COVID-19 infection

AI is a viable alternative to high throughput screening: a 318-target study

: High throughput screening (HTS) is routinely used to identify bioactive small molecules. This requires physical compounds, which limits coverage of accessible chemical space. Computational approaches combined with vast on-demand chemical libraries can access far greater chemical space, provided that the predictive accuracy is sufficient to identify useful molecules. Through the largest and most diverse virtual HTS campaign reported to date, comprising 318 individual projects, we demonstrate that our AtomNet® convolutional neural network successfully finds novel hits across every major therapeutic area and protein class. We address historical limitations of computational screening by demonstrating success for target proteins without known binders, high-quality X-ray crystal structures, or manual cherry-picking of compounds. We show that the molecules selected by the AtomNet® model are novel drug-like scaffolds rather than minor modifications to known bioactive compounds. Our empirical results suggest that computational methods can substantially replace HTS as the first step of small-molecule drug discovery

Statement of Second Brazilian Congress of Mechanical Ventilarion : part I

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Bradyrhizobium ottawaense efficiently reduces nitrous oxide through high nosZ gene expression

Abstract N2O is an important greenhouse gas influencing global warming, and agricultural land is the predominant (anthropogenic) source of N2O emissions. Here, we report the high N2O-reducing activity of Bradyrhizobium ottawaense, suggesting the potential for efficiently mitigating N2O emission from agricultural lands. Among the 15 B. ottawaense isolates examined, the N2O-reducing activities of most (13) strains were approximately five-fold higher than that of Bradyrhizobium diazoefficiens USDA110T under anaerobic conditions. This robust N2O-reducing activity of B. ottawaense was confirmed by N2O reductase (NosZ) protein levels and by mitigation of N2O emitted by nodule decomposition in laboratory system. While the NosZ of B. ottawaense and B. diazoefficiens showed high homology, nosZ gene expression in B. ottawaense was over 150-fold higher than that in B. diazoefficiens USDA110T, suggesting the high N2O-reducing activity of B. ottawaense is achieved by high nos expression. Furthermore, we examined the nos operon transcription start sites and found that, unlike B. diazoefficiens, B. ottawaense has two transcription start sites under N2O-respiring conditions, which may contribute to the high nosZ expression. Our study indicates the potential of B. ottawaense for effective N2O reduction and unique regulation of nos gene expression towards the high performance of N2O mitigation in the soil