Modelling Cross-Document Interdependencies in Medieval Charters of the St. Katharinenspital in Regensburg

To overcome the limitations of structural XML mark-up, graph-based data models and graph databases, as well as event-based ontologies like CIDOC-CRM (FORTH-ICS 2018) have been considered for the creation of digital editions. We apply the graph-based approach to model charter regests and extend it with the CIDOC-CRM ontology, as it allows us to integrate information from different sources into a flexible data model. By implementing the ontology within the Neo4j graph database (Neo4j 2018) we create a sustainable data source that allows explorative search queries and finally, the integration of the database in various technical systems. Our use case are the charters from the St. Katharinenspital, a former medieval hospital in Regensburg, Germany. By analysing charter abstracts with natural language processing (NLP) methods and using additional data sources related to the charters, we generate additional metadata. The extracted information allows the modelling of cross-document interdependencies of charter regests and their related entities. Building upon this, we develop an exploratory web application that allows to investigate a graph-based digital edition. Thereby, each entity is displayed in its unique context, i.e., it is shown together with its related entities (next neighbours) in the graph. We use this to enhance the result lists of a full-text search, and to generate entity-specific detail pages

Korpusbasierte Analyse österreichischer Parlamentsreden

Dieser Beitrag beschreibt, wie aus Plenarprotokollen des Österreichischen Nationalrats generierte Korpora computerbasiert analysiert werden können. Konkret sollen dabei mit korpuslinguistischen Methoden diskursspezifische Schlagwörter und Wortgruppen (n-Gramme) aus den Nationalratsreden extrahiert werden. In einer Fallstudie wird auf die Beiträge der Abgeordneten zweier im politischen Spektrum weit voneinander entfernter Parteien fokussiert: GRÜNE und FPÖ. Mit Hilfe der so gewonnenen Daten soll die inhaltliche Analyse der stenografischen Protokolle erleichtert werden und die kontrastive Gegenüberstellung beispielsweise von Positionen, politischen Konzepten oder Wertvorstellungen in den Reden der Abgeordneten der unterschiedlichen Parteien ermöglicht werden

Protokoll zum EZB-Anwendertreffen am 15.11.2023

0. Begrüßung und Organisatorisches 1. Stand der Entwicklung 2. Neuerungen in der EZB 2.1. Qualitätspflege der EZB-Daten 2.2. Verbesserungen in der EZB-Administration 2.3. Anpassungen an der EZB-Benutzeroberfläche 3. Schnittstellen und Datenlieferdienste 3.1. Umstellung der EZB-ZDB-Datenlieferung 3.2. Nachnutzung der EZB-Kollektionen in ALMA und der GOKb 3.3. Nachnutzung der EZB-Zeitschriftendaten 4. Bericht aus dem EZB-DBIS-Beirat 5. Kooperative Projekte und Vernetzung 5.1. Redesign der HTML-Ausgabe von Journals Online & Print 5.2. Mir@abel, a French EZB 5.3. DFG-Projekt openCost 5.4. AG Systemlandschaft E-Ressourcen 6. Anregungen der EZB-Anwende

Graph Data-Models and Semantic Web Technologies in Scholarly Digital Editing

This volume is based on the selected papers presented at the Workshop on Scholarly Digital Editions, Graph Data-Models and Semantic Web Technologies, held at the Uni- versity of Lausanne in June 2019. The Workshop was organized by Elena Spadini (University of Lausanne) and Francesca Tomasi (University of Bologna), and spon- sored by the Swiss National Science Foundation through a Scientific Exchange grant, and by the Centre de recherche sur les lettres romandes of the University of Lausanne. The Workshop comprised two full days of vibrant discussions among the invited speakers, the authors of the selected papers, and other participants.1 The acceptance rate following the open call for papers was around 60%. All authors – both selected and invited speakers – were asked to provide a short paper two months before the Workshop. The authors were then paired up, and each pair exchanged papers. Paired authors prepared questions for one another, which were to be addressed during the talks at the Workshop; in this way, conversations started well before the Workshop itself. After the Workshop, the papers underwent a second round of peer-review before inclusion in this volume. This time, the relevance of the papers was not under discus- sion, but reviewers were asked to appraise specific aspects of each contribution, such as its originality or level of innovation, its methodological accuracy and knowledge of the literature, as well as more formal parameters such as completeness, clarity, and coherence. The bibliography of all of the papers is collected in the public Zotero group library GraphSDE20192, which has been used to generate the reference list for each contribution in this volume. The invited speakers came from a wide range of backgrounds (academic, commer- cial, and research institutions) and represented the different actors involved in the remediation of our cultural heritage in the form of graphs and/or in a semantic web en- vironment. Georg Vogeler (University of Graz) and Ronald Haentjens Dekker (Royal Dutch Academy of Sciences, Humanities Cluster) brought the Digital Humanities research perspective; the work of Hans Cools and Roberta Laura Padlina (University of Basel, National Infrastructure for Editions), as well as of Tobias Schweizer and Sepi- deh Alassi (University of Basel, Digital Humanities Lab), focused on infrastructural challenges and the development of conceptual and software frameworks to support re- searchers’ needs; Michele Pasin’s contribution (Digital Science, Springer Nature) was informed by his experiences in both academic research, and in commercial technology companies that provide services for the scientific community. The Workshop featured not only the papers of the selected authors and of the invited speakers, but also moments of discussion between interested participants. In addition to the common Q&A time, during the second day one entire session was allocated to working groups delving into topics that had emerged during the Workshop. Four working groups were created, with four to seven participants each, and each group presented a short report at the end of the session. Four themes were discussed: enhancing TEI from documents to data; ontologies for the Humanities; tools and infrastructures; and textual criticism. All of these themes are represented in this volume. The Workshop would not have been of such high quality without the support of the members of its scientific committee: Gioele Barabucci, Fabio Ciotti, Claire Clivaz, Marion Rivoal, Greta Franzini, Simon Gabay, Daniel Maggetti, Frederike Neuber, Elena Pierazzo, Davide Picca, Michael Piotrowski, Matteo Romanello, Maïeul Rouquette, Elena Spadini, Francesca Tomasi, Aris Xanthos – and, of course, the support of all the colleagues and administrative staff in Lausanne, who helped the Workshop to become a reality. The final versions of these papers underwent a single-blind peer review process. We want to thank the reviewers: Helena Bermudez Sabel, Arianna Ciula, Marilena Daquino, Richard Hadden, Daniel Jeller, Tiziana Mancinelli, Davide Picca, Michael Piotrowski, Patrick Sahle, Raffaele Viglianti, Joris van Zundert, and others who preferred not to be named personally. Your input enhanced the quality of the volume significantly! It is sad news that Hans Cools passed away during the production of the volume. We are proud to document a recent state of his work and will miss him and his ability to implement the vision of a digital scholarly edition based on graph data-models and semantic web technologies. The production of the volume would not have been possible without the thorough copy-editing and proof reading by Lucy Emmerson and the support of the IDE team, in particular Bernhard Assmann, the TeX-master himself. This volume is sponsored by the University of Bologna and by the University of Lausanne. Bologna, Lausanne, Graz, July 2021 Francesca Tomasi, Elena Spadini, Georg Vogele

Masitinib (AB1010), a Potent and Selective Tyrosine Kinase Inhibitor Targeting KIT

International audienceBackground: The stem cell factor receptor, KIT, is a target for the treatment of cancer, mastocytosis, and inflammatory diseases. Here, we characterise the in vitro and in vivo profiles of masitinib (AB1010), a novel phenylaminothiazole-type tyrosine kinase inhibitor that targets KIT. Methodology/Principal Findings: In vitro, masitinib had greater activity and selectivity against KIT than imatinib, inhibiting recombinant human wild-type KIT with an half inhibitory concentration (IC50) of 200 ± 40 nM and blocking stem cell factor-induced proliferation and KIT tyrosine phosphorylation with an IC50 of 150 ± 80 nM in Ba/F3 cells expressing human or mouse wild-type KIT. Masitinib also potently inhibited recombinant PDGFR and the intracellular kinase Lyn, and to a lesser extent, fibroblast growth factor receptor 3. In contrast, masitinib demonstrated weak inhibition of ABL and c-Fms and was inactive against a variety of other tyrosine and serine/threonine kinases. This highly selective nature of masitinib suggests that it will exhibit a better safety profile than other tyrosine kinase inhibitors; indeed, masitinib-induced cardiotoxicity or genotoxicity has not been observed in animal studies. Molecular modelling and kinetic analysis suggest a different mode of binding than imatinib, and masitinib more strongly inhibited degranulation, cytokine production, and bone marrow mast cell migration than imatinib. Furthermore, masitinib potently inhibited human and murine KIT with activating mutations in the juxtamembrane domain. In vivo, masitinib blocked tumour growth in mice with subcutaneous grafts of Ba/F3 cells expressing a juxtamembrane KIT mutant. Conclusions: Masitinib is a potent and selective tyrosine kinase inhibitor targeting KIT that is active, orally bioavailable in vivo, and has low toxicit

openCost: Transparenz von Publikationskosten durch neue Funktionen in der Elektronischen Zeitschriftenbibliothek (EZB)

Die EZB wird im Rahmen des openCost-Projekts (DFG-Projektnr. 457354095) um neue Funktionen, Daten und Informationen zu Publikationskosten erweitert. Diese Neuerungen beziehen sowohl EZB-Daten als auch externe Informationen ein. Ziel ist es, den EZB-Nutzern sowohl einrichtungsunabhängige als auch einrichtungsspezifische Informationen zur Übernahme von Publikationskosten bereitzustellen und ferner mehr Kostentransparenz zu schaffen. Hierzu werden Zeitschriften in der EZB um weitere Informationen angereichert und mit neuen Kategorien ausgezeichnet. Beispiele hierfür sind 'Indexed in DOAJ' oder „Mirror Journal“, wobei dazu etablierte Quellen, etwa die Titelliste der Mirror Journal Working Group oder das DOAJ nachgenutzt werden. Zeitschriftenkategorien, für die es hingegen keine Datenquelle gibt, werden in der EZB manuell vergeben und dann zur Nachnutzung bereitgestellt, wie z.B. „Subscribe to Open-Journals“. Neben der Auszeichnung von Zeitschriften werden in der EZB zentral gepflegte Titellisten, sogenannte EZB-Kollektionen, die Teil eines Transformationsvertrags sind, gekennzeichnet und mit der zugehörigen ESAC-ID verknüpft. Ferner sollen zu einem späteren Zeitpunkt für ausgewählte Pilotbibliotheken Kosteninformationen aus OpenAPC abgerufen und in die EZB-Benutzeroberfläche eingebunden werden. Dadurch erhalten die Nutzer Kosteninformationen zu einer Zeitschrift, wie etwa die durchschnittlichen APCs einer Zeitschrift als zusätzliche Information in der EZB-Detailseite. Schließlich soll für EZB-Einrichtungen eine Eingabemöglichkeit geschaffen werden, um individuelle Vereinbarungen mit Verlagen, wie z.B. Mitgliedschaften, zu hinterlegen. Diese Informationen sollen in der EZB einrichtungsspezifisch für die einzelnen Zeitschriften angezeigt und zur weiteren Nutzung bereitgestellt werden

Spreading publication cost information with the Electronic Journals Library (EZB)

The Electronic Journals Library (EZB) provides information on more than 110,000 electronic journals from all subject areas, including 74,000 freely available titles. Over 650 libraries and research institutions jointly maintain the EZB data, which is of high quality and up to date.EZB data are used for various user services and numerous services for the supply of literature and research information. In the openCost project, the EZB will be expanded to include special functions for displaying publication costs, which will also be made available for further use

Spreading Publication Cost Information with the Electronic Journals Library (EZB)

The Electronic Journals Library (EZB) presents e-journals to library users in a clearly structured, user-friendly interface and provides its member libraries with an efficient administrative tool for e-journal licenses. Furthermore, the EZB offers information on more than 110,000 e-journals from all subject areas, including 75,000 freely available titles. Over 650libraries and research institutions – mostly from German-speaking countries– jointly maintain the EZB data, ensuring that journal information is of a high standard and constantly updated.This makes the EZB a reliable hub for high-quality, up-to-date data in the library world. It provides data for various user services delivering literature and research information. Within the scope of the openCost project, the EZB will be further extended by additional data on publication costs and new functionalities for displaying and delivering these cost data via various existing EZB interfaces. These innovations include enhanced user information on whether their institution covers these publication costs,either via transformative agreements or via its publication funds. This is also being achieved by means of new journal categories, an OpenAPC integration, and better integration of transformative agreements via ESAC-IDs into EZB data. Following this path, the EZB is making a significant contribution to greater publication cost transparency