Seismic Hazard Prediction on Basis of Risk Targeted MCE Using Clustering

A natural disaster is that the results of a natural hazard(e.g. flood, tornado, volcanic eruption, earthquake, heat wave, or landslide).Earthquake, landslide, tsunamis and volcanoes area unit sophisticated phenomenon that finishes up in cash ,environment or human losses. This paper highlight the knowledge mining techniques applied to mine for surface changes over time (e,g. Earthquake rupture). the knowledge mining techniques facilitate researchers to predict the changes at intervals the intensity of volcano. This paper uses apocalyptical math models which can be applied to areas like unstable activity. This analysis proposes a technique mistreatment data processing to analyze patterns in seismic information for earthquake prediction. Recent trends in earthquake observation and prediction have targeted on the observation of seismic frequencies that square measure terribly near the natural frequencies of buildings and different structures, like bridges

Antimonocyte antibodies in Takayasu's arteritis: prevalence of and relation to disease activity

Objective: To investigate the prevalence of antimonocyte antibodies (AMA) in Takayasu's arteritis (TA) and their relationship with disease activity. Methods: IgG-AMA were studied in the sera of 60 patients with TA (29 active disease, 31 inactive) and 43 controls by a cellular ELISA using glutaraldehyde fixed U-937 cells or peripheral blood monocytes as antigen. Relationship of AMA with disease activity was evaluated by measuring titers of these antibodies in followup sera of 15 AMA positive patients with active TA undergoing immunosuppressive therapy. Results: Twenty-six of 60 TA patients (43%) compared to 4 of 43 controls (9%) (p < 0.001) and 20 of 29 patients with active disease (69%) compared to 6 of 31 patients with inactive disease (19%) (p < 0.001) were positive for AMA. The antibody titers were significantly higher in patients with active disease than those with inactive disease (0.396 +/− 0.172 vs 0.232 +/− 0.096; p < 0.001). In the followup study of 15 patients with active disease who received immunosuppressive therapy, we observed normalization of AMA titers in 6 of the 7 patients who became inactive, compared to only one of the 8 patients whose disease remained active during followup (p < 0.01). Conclusion: AMA are present in a significant proportion of patients with TA and correlate with disease activity, suggesting a possible pathogenic role of these antibodies in TA

Variation in COVID-19 management outcome with progression of pandemic- An observational study of a tertiary covid care centre

Introduction: Uttarakhand reported its first case of SARS-COV-2 on 15th march 2020. This study is a retrospective descriptive analysis of the changing demographic, clinical and case fatality rate of the disease with the progression of pandemic. Material and methods: The study is on the data of the admitted patients in a tertiary level facility from March 2020- February 2021. Data was analysed in terms of outcome of the admitted patients and the change in the clinical presentation and demographic profile of disease in the admitted patients with progression of disease over the stipulated time frame. Factors affecting the mortality of the admitted cases were also analysed. Results: Symptomatic cases admitted in months of March 2020-July 2020 was 39% while those in month of August 2020-Feburary 2021 formed 90.3% of total admission (p< 0.00001). Case Fatality Rate in age group of >= 60 years was 16% while in <=60 years it was 3.2% (p<0.00001). Comorbidities were associated with 68.8% (n=209) of deaths, of which predominant was diabetes (44%). Out of 139 deaths, 35% were attributed to acute respiratory distress syndrome/Respiratory Failure, 37% were due to Cardiac events while Sepsis with Multiple Organ Dysfunction Syndrome was responsible for 285 mortalities. Conclusion: Home Isolation policy of the COVID-19 positive cases with the advancing pandemic had an adverse impact on the clinical profile, demographic profile and the mortality rate of the admitted patients. Early treatment policy of the admitted SARS-COV-2 positive asymptomatic or symptomatic patients did affect the outcome of the admitted patients in the early phase of the pandemic. Ae more than 60 years and also the co-morbidities are an independent risk factor for mortality in COVID-19 and also the co-morbidities

T-cell receptor repertoire of circulating gamma delta t-cells in Takayasu's arteritis

We studied T-cell receptor (TCR) repertoire of circulating gamma delta ( γδ) T-cells in 20 patients with Takayasu's arteritis (TA), 20 healthy controls (HC), 7 follow up TA patients, and 10 patients with rheumatoid arthritis (RA) and 5 Wegener's granulomatosis (WG) patients as disease controls. Patients with TA (8.1 ± 5.1%) compared to HC (3.7 ± 2.1%, P = 0.014), RA (4.8 ± 0.6%, P = 0.032), and WG (4.2 ± 0.8%, P = 0.030) as well as active TA compared to inactive TA (13.9 ± 4.1% vs. 4.9 ± 1.5%; P < 0.001) had higher number of γδ T-cells. The numbers of Vδ1+ cells were significantly higher in patients with TA (40.0 ± 20.8%) than HC (13.1 ± 8.0%; P = 0.001), RA (19.5 ± 1.8%, P = 0.004), and WG (17.0 ± 3.9%, P = 0.007). The numbers of γδ T-cells normalized in all the 7 patients after 180 days of follow up (13.9 ± 4.1% vs. 6.9 ± 2.5%; P = 0.001). We also observed higher number of activated and IFN-γ producing γδ T-cells in active TA. Our data show that γδ T-cells particularly those bearing Vd1 TCR may have an important role in the immunopathogenesis of TA

Recurrent acute coronary events in a patient with primary Antiphospholipid syndrome: successful management with intracoronary stenting

Patients with Antiphospholipid syndrome usually present with recurrent deep vein thrombosis, pulmonary thromboembolism and thromboembolic stroke. Recurrent coronary events, though reported, are rare. We describe an unusual case of Antiphospholipid syndrome who presented with recurrent acute ischaemic events in two different coronary territories, who was managed successfully with intracoronary stenting

Soluble endothelial cell adhesion molecules and their relationship with disease activity

Objective: To investigate soluble (s) E-selectin, vascular cell adhesion molecule-1 (VCAM-1), and intercellular cell adhesion molecule-1 (ICAM-1), and their relationship to disease activity in Takayasu's arteritis (TA). Methods: Levels of adhesion molecules were measured by enzyme immunoassay in the sera of 35 patients with TA, 17 healthy controls, and 15 patients with 12 months followup. Results: Compared to controls, patients had elevated levels of sE-selectin (54.5 ± 35.0 vs 36.4 ± 13.0 ng/ml, p < 0.05), sVCAM-1 (280.9 ± 267.6 vs 141.2 ± 76.1 ng/ml, p < 0.05), and sICAM-1 (261.3 ± 168.1 vs 198.3 ± 74.3 ng/ml, p< 0.05). Compared to controls, patients with inactive TA also had elevated levels of sE-selectin (67.4 ± 45.9 vs 36.4 ± 13.0 ng/ml, p < 0.02), sVCAM-1 (327.6 ± 327.8 vs 141.2 ± 76.1 ng/ml, p < 0.02), and sICAM-1 (321.9 ± 179.5 vs 198.3 ±74.3 ng/ml, p < 0.02). There was no difference between active TA and controls. sE-selectin had a trend towards increased levels in inactive versus active TA (67.4 ± 45.9 vs 44.9 ± 20.3 ng/ml p = 0.059), but there was no difference in sVCAM-1 and sICAM-1 levels between the groups. No adhesion molecule levels showed a change among followup patients. Conclusion: Patients with inactive TA have elevated levels of sE-selectin, sVCAM-1, and sICAM-1 that might indicate persistent vasculopathy in clinically inactive disease

Role of immunosuppressive therapy on clinical, immunological, and angiographic outcome in active Takayasu's arteritis

Objective: To evaluate the role of an immunosuppressive regimen consisting of azathioprine and prednisolone on the clinical, immunological, and angiographic outcome in patients with active Takayasu's arteritis (TA). Methods: Between January 1996 and January 2001, of 65 consecutive newly diagnosed patients with TA not previously treated by any immunosuppressive therapy, 15 fulfilled the criteria for disease activity. Detailed clinical and laboratory evaluation was carried out in these patients. They were treated with a combination of azathioprine and prednisolone for one year, and aortography was carried out in all patients before and after completion of the treatment. Results: All patients had improvement in systemic symptoms and laboratory measures of disease activity within a period of 3 months of onset of treatment. Erythrocyte sedimentation rate decreased from a mean of 55.5 +/− 14.7 mm/h to 21.9 +/− 9.5 mm/h within 3 months (p < 0.001) and further to 20.8 +/− 15.2 at one year (p = NS). C-reactive protein concentrations fell from 4.8 +/− 5.2 mg/dl to 0.5 +/− 0.2 mg/dl at 3 months (p = 0.004) and remained at 0.5 +/− 0.3 mg/dl at one year (p = NS). No changes in the peripheral pulses or differences in limb blood pressures were noted. Repeat angiograms revealed no significant changes compared to baseline. No new lesion appeared in any patient. The immunosuppressive therapy was well tolerated with no notable side effects. Conclusion: An immunosuppressive regimen of azathioprine and prednisolone is safe, well tolerated, and effective in ameliorating systemic symptoms and laboratory measures of disease activity in TA, and at least halts progression in angiographic lesions at one year of followup, although it does not seem to lead to a regression of the arterial lesions

Zebrafish G protein γ2 is required for VEGF signaling during angiogenesis

Vascular endothelial growth factor (VEGF) is a major mediator of pathologic angiogenesis, a process necessary for the formation of new blood vessels to support tumor growth. Historically, VEGF has been thought to signal via receptor tyrosine kinases, which are not typically considered to be G protein dependent. Here, we show that targeted knockdown of the G protein gng2 gene (Gγ2) blocks the normal angiogenic process in developing zebrafish embryos. Moreover, loss of gng2 function inhibits the ability of VEGF to promote the angiogenic sprouting of blood vessels by attenuating VEGF induced phosphorylation of phospholipase C-gamma1 (PLCγ1) and serine/threonine kinase (AKT). Collectively, these results demonstrate a novel interaction between Gγ2- and VEGF-dependent pathways to regulate the angiogenic process in a whole-animal model. Blocking VEGF function using a humanized anti-VEGF antibody has emerged as a promising treatment for colorectal, non-small lung cell, and breast cancers. However, this treatment may cause considerable side effects. Our findings provide a new opportunity for cotargeting G protein- and VEGF-dependent pathways to synergistically block pathologic angiogenesis, which may lead to a safer and more efficacious therapeutic regimen to fight cancer. (Blood. 2006;108:160-166

Book of Abstracts of the 2nd International Conference on Applied Mathematics and Computational Sciences (ICAMCS-2022)

It is a great privilege for us to present the abstract book of ICAMCS-2022 to the authors and the delegates of the event. We hope that you will find it useful, valuable, aspiring, and inspiring. This book is a record of abstracts of the keynote talks, invited talks, and papers presented by the participants, which indicates the progress and state of development in research at the time of writing the research article. It is an invaluable asset to all researchers. The book provides a permanent record of this asset. Conference Title: 2nd International Conference on Applied Mathematics and Computational SciencesConference Acronym: ICAMCS-2022Conference Date: 12-14 October 2022Conference Organizers: DIT University, Dehradun, IndiaConference Mode: Online (Virtual