Preliminary Investigation of Antipyretic Activity of Trinpanchmool Extracts

Current research work is to evaluate the antipyretic activity of hydro-alcoholic extract of trinpanchmool on the wistar rats. Brewer’s yeast induced pyrexia method was used to evaluate febrifuge effect of trinpanchmool extract along with its comparison with its individual constituents on the wistar rats. Darbh, Ikshu and SAR was having better antipyretic activity than the standard drug paracetamol. Combination of the drugs was having better antipyretic that paracetamol but lesser than the individual drugs. Trinpanchmool and its individual drugs are having febrifugatic effect better than our standard paracetamol

Preliminary Investigation of Antipyretic Activity of Trinpanchmool Extracts

Current research work is to evaluate the antipyretic activity of hydro-alcoholic extract of trinpanchmool on the wistar rats. Brewer’s yeast induced pyrexia method was used to evaluate febrifuge effect of trinpanchmool extract along with its comparison with its individual constituents on the wistar rats. Darbh, Ikshu and SAR was having better antipyretic activity than the standard drug paracetamol. Combination of the drugs was having better antipyretic that paracetamol but lesser than the individual drugs. Trinpanchmool and its individual drugs are having febrifugatic effect better than our standard paracetamol

Scientific Assessment of Antioxidant Potential of Pyrimidine-2,4(1H, 3H)-diones

ABSTRACT: The aim of present research work is to screen some pyrimidine-2,4-diones for their potential anti-oxidant activity to prevent the progress of free radical mediated disorders using different in-vitro models like nitric oxide(NO) scavenging activity and ferric reducing anti-oxidant power. Results revealed that pyrimidine-2,4-diones have significant anti-oxidant activity and OBP-05 is the most potent antioxidant as per the overall radical scavenging capabilities, but OBP-10 have specifically higher nitric oxide scavenging(IC 50 3.38 µg/ml) potential than that of OBP-05(IC 50 4.51 µg/ml)

Mechanistic Explorations of Antidiabetic Potentials of Sansevieria Trifasciata

ABSTRACT: There has been a great resurgence of interest in phyto-therapy in treating chronic diseases like Type 2 diabetes. The current research aims to explore the mechanistic anti-diabetic potentials of the leaves and rhizomes of Sansevieria trifasciata (ST). Chemo-profiling by phytochemical tests and GC-MS analysis have shown the presence of phenolics, alkaloids, terpenoids, flavonoids, saponins, steroids and glycosides. The median lethal dose was found to be 500 mg/kg on acute toxicity studies. The extract showed statistically significant (p<0.001 and p<0.05) hypoglycemia on fasting and oral glucose challenge; body weight (p<0.001) determination and quenching of TBARS (p<0.001); the facts being further supported by histopathological assessment. The flow cytometric data revealed the beneficial role of plant extract in preventing apoptotic cell death under hyperglycemic conditions and results of Western blot analysis showed reduced expressions of the vascular inflammation markers on administration of plant extract

Maize and heat stress: Physiological, genetic, and molecular insights

Global mean temperature is increasing at a rapid pace due to the rapid emission of greenhouse gases majorly from anthropogenic practices and predicted to rise up to 1.5˚C above the pre-industrial level by the year 2050. The warming climate is affecting global crop production by altering biochemical, physiological, and metabolic processes resulting in poor growth, development, and reduced yield. Maize is susceptible to heat stress, particularly at the reproductive and early grain filling stages. Interestingly, heat stress impact on crops is closely regulated by associated environmental covariables such as humidity, vapor pressure deficit, soil moisture content, and solar radiation. Therefore, heat stress tolerance is considered as a complex trait, which requires multiple levels of regulations in plants. Exploring genetic diversity from landraces and wild accessions of maize is a promising approach to identify novel donors, traits, quantitative trait loci (QTLs), and genes, which can be introgressed into the elite cultivars. Indeed, genome wide association studies (GWAS) for mining of potential QTL(s) and dominant gene(s) is a major route of crop improvement. Conversely, mutation breeding is being utilized for generating variation in existing populations with narrow genetic background. Besides breeding approaches, augmented production of heat shock factors (HSFs) and heat shock proteins (HSPs) have been reported in transgenic maize to provide heat stress tolerance. Recent advancements in molecular techniques including clustered regularly interspaced short palindromic repeats (CRISPR) would expedite the process for developing thermotolerant maize genotypes

Assessment of the impact of intravenous antibiotics treatment on gut microbiota in patients: Clinical data from pre-and post-cardiac surgery

Background and aimsSurgical site infection is a common complication after surgery. Periprocedural antibiotics are necessary to prescribe for preventing or treating infections. The present study aimed to explore the effect of intravenous antibiotics on gut microbiota and menaquinone biosynthesis in patients, especially in elderly patients undergoing cardiac surgery.MethodsA total of 388 fecal samples were collected from 154 cardiac surgery patients. The V3–V4 hypervariable region of the bacterial 16S rRNA gene was amplified and sequenced on a MiSeq PE300. The gut microbiota diversity of samples was analyzed in terms of α- and β-diversity at the OTU level. The different groups were classified according to antibiotics in combinations and single antibiotics. PICRUSt2 was used for preliminary prediction of the gut microbiota function for menaquinone biosynthesis.ResultsThe intravenously administered antibiotics which are excreted via bile represents the main antibiotics that could disturb the gut microbiota’s composition in cardiac surgery patients, especially for elderly patients. The effect of antibiotics on gut microbiota is produced after antibiotics treatments over one week. The recovery of gut microbiota to the state of pre-antibiotics may require over two weeks of antibiotics withdrawal. Sex factor doesn’t represent as an influencer in gut microbiota composition. Long-term use of cefoperazone-sulbactam may affect coagulation function.ConclusionsThe composition of the gut microbiota had a significant change post-intravenous antibiotics treatment in cardiac surgery patients. The richness and diversity of gut microbiota are increased in elderly patients

Impacts of biomedical hashtag-based Twitter campaign: #DHPSP utilization for promotion of open innovation in digital health, patient safety, and personalized medicine

The open innovation hub Digital Health and Patient Safety Platform (DHPSP) was recently established with the purpose to invigorate collaborative scientific research and the development of new digital products and personalized solutions aiming to improve human health and patient safety. In this study, we evaluated the effectiveness of a Twitter-based campaign centered on using the hashtag #DHPSP to promote the visibility of the DHPSP initiative. Thus, tweets containing #DHPSP were monitored for five weeks for the period 20.10.2020–24.11.2020 and were analyzed with Symplur Signals (social media analytics tool). In the study period, a total of 11,005 tweets containing #DHPSP were posted by 3020 Twitter users, generating 151,984,378 impressions. Analysis of the healthcare stakeholder-identity of the Twitter users who used #DHPSP revealed that the most of participating user accounts belonged to individuals or doctors, with the top three user locations being the United States (501 users), the United Kingdom (155 users), and India (121 users). Analysis of co-occurring hashtags and the full text of the posted tweets further revealed that the major themes of attention in the #DHPSP Twitter-community were related to the coronavirus disease 2019 (COVID-19), medicine and health, digital health technologies, and science communication in general. Overall, these results indicate that the #DHPSP initiative achieved high visibility and engaged a large body of Twitter users interested in the DHPSP focus area. Moreover, the conducted campaign resulted in an increase of DHPSP member enrollments and website visitors, and new scientific collaborations were formed. Thus, Twitter campaigns centered on a dedicated hashtag prove to be a highly efficient tool for visibility-promotion, which could be successfully utilized by healthcare-related open innovation platforms or initiatives

The International Natural Product Sciences Taskforce (INPST) and the power of Twitter networking exemplified through #INPST hashtag analysis

Background: The development of digital technologies and the evolution of open innovation approaches have enabled the creation of diverse virtual organizations and enterprises coordinating their activities primarily online. The open innovation platform titled "International Natural Product Sciences Taskforce" (INPST) was established in 2018, to bring together in collaborative environment individuals and organizations interested in natural product scientific research, and to empower their interactions by using digital communication tools. Methods: In this work, we present a general overview of INPST activities and showcase the specific use of Twitter as a powerful networking tool that was used to host a one-week "2021 INPST Twitter Networking Event" (spanning from 31st May 2021 to 6th June 2021) based on the application of the Twitter hashtag #INPST. Results and Conclusion: The use of this hashtag during the networking event period was analyzed with Symplur Signals (https://www.symplur.com/), revealing a total of 6,036 tweets, shared by 686 users, which generated a total of 65,004,773 impressions (views of the respective tweets). This networking event's achieved high visibility and participation rate showcases a convincing example of how this social media platform can be used as a highly effective tool to host virtual Twitter-based international biomedical research events