Hi - Diddle - Diddle

With Ukulele arrangement. Contains advertisements and/or short musical examples of pieces being sold by publisher.https://digitalcommons.library.umaine.edu/mmb-vp/7083/thumbnail.jp

Embedding the affine complement of three intersecting lines in a finite projective plane

An (r, 1)–design is a pair (V, F) where V is a ν–set and F is a family of non-null subsets of V (b in number) which satisfy the following. (1) Every pair of distinct members of V is contained in precisely one member of F. (2) Every member of V occurs in precisely r members of F. A pseudo parallel complement PPC(n, α) is an (n+1, 1)–design with ν=n2−αn and b≦n2+n−α in which there are at least n−α a blocks of size n. A pseudo intersecting complement PIC(n, α) is an (n+1, 1)–design with ν=n2−αn+α−1 and b≦n2+n−α in which there are at least n−α+1 blocks of size n−1. It has previously been shown that for α≦4, every PIC(n, α) can be embedded in a PPC(n, α−1) and that for n>(α4−2α3+2α2+α−2)/2, every PPC(n, α) can be embedded in a finite projective plane of order n. In this paper we investigate the case of α=3 and show that any PIC(n, 3) is embeddable in a PPC(n,2) provided n≧14

The Bells of St. Mary\u27s

https://digitalcommons.library.umaine.edu/mmb-vp/1093/thumbnail.jp

The Bells of St. Mary\u27s

https://digitalcommons.library.umaine.edu/mmb-vp/1094/thumbnail.jp

The Bells of St. Mary\u27s

https://digitalcommons.library.umaine.edu/mmb-vp/1093/thumbnail.jp

Enhanced Neutrophil Extracellular Trap Formation in Acute Pancreatitis Contributes to Disease Severity and Is Reduced by Chloroquine

Background: Neutrophil extracellular traps (NETs) are generated when activated neutrophils, driven by PAD4, release their DNA, histones, HMGB1, and other intracellular granule components. NETs play a role in acute pancreatitis, worsening pancreatic inflammation, and promoting pancreatic duct obstruction. The autophagy inhibitor chloroquine (CQ) inhibits NET formation; therefore, we investigated the impact of CQ mediated NET inhibition in murine models of pancreatitis and human correlative studies. Methods: L-arginine and choline deficient ethionine supplemented (CDE) diet models of acute pancreatitis were studied in wild type and PAD4−/− mice, incapable of forming NETs. Isolated neutrophils were stimulated to induce NET formation and visualized with fluorescence microscopy. CQ treatment (0.5 mg/ml PO) was initiated after induction of pancreatitis. Biomarkers of NET formation, including cell-free DNA, citrullinated histone H3 (CitH3), and MPO-DNA conjugates were measured in murine serum and correlative human patient serum samples. Results: We first confirmed the role of NETs in the pathophysiology of acute pancreatitis by demonstrating that PAD4−/− mice had decreased pancreatitis severity and improved survival compared to wild-type controls. Furthermore, patients with severe acute pancreatitis had elevated levels of cell-free DNA and MPO-DNA conjugates, consistent with NET formation. Neutrophils from mice with pancreatitis were more prone to NET formation and CQ decreased this propensity to form NETs. CQ significantly reduced serum cell-free DNA and citrullinated histone H3 in murine models of pancreatitis, increasing survival in both models. Conclusions: Inhibition of NETs with CQ decreases the severity of acute pancreatitis and improves survival. Translating these findings into clinical trials of acute pancreatitis is warranted

High rate, fast timing Glass RPC for the high {\eta} CMS muon detectors

The HL-LHC phase is designed to increase by an order of magnitude the amount of data to be collected by the LHC experiments. To achieve this goal in a reasonable time scale the instantaneous luminosity would also increase by an order of magnitude up to $6.10^{34} cm^{-2} s^{-1}$ . The region of the forward muon spectrometer ($|{\eta}| > 1.6$) is not equipped with RPC stations. The increase of the expected particles rate up to $2 kHz/cm^{2}$ (including a safety factor 3) motivates the installation of RPC chambers to guarantee redundancy with the CSC chambers already present. The actual RPC technology of CMS cannot sustain the expected background level. The new technology that will be chosen should have a high rate capability and provides a good spatial and timing resolution. A new generation of Glass-RPC (GRPC) using low-resistivity (LR) glass is proposed to equip at least the two most far away of the four high ${\eta}$ muon stations of CMS. First the design of small size prototypes and studies of their performance in high-rate particles flux is presented. Then the proposed designs for large size chambers and their fast-timing electronic readout are examined and preliminary results are provided.Comment: 14 pages, 11 figures, Conference proceeding for the 2016 Resistive Plate Chambers and Related Detector