A new approach to find an approximate solution of linear initial value problems with high degree of accuracy

This work investigates a new approach to find closed form solution to linear initial value problems (IVP). Classical Bernoulli polynomials have been used to derive a finite set of orthonormal polynomials and a finite operational matrix to simplify derivatives in IVP. These orthonormal polynomials together with the operational matrix of relevant order provides a robust approximation to the solution of a linear initial value problem by converting the IVP into a set of algebraic equations. Depending upon the nature of a problem, a polynomial of degree n or numerical approximation can be obtained. The technique has been demonstrated through four examples. In each example, obtained solution has been compared with available exact or numerical solution. High degree of accuracy has been observed in numerical values of solutions for considered problems

Isolation of new racemic sugar (D/L galacturonic acid) from leaves of Paederia foetida Linn.

New racemic sugars (D/L galacturonic acid) were isolate from the leaves of Paederia foetida Linn by the column chromatography. Identification of these isolated compound achieved by TLC, 1H-NMR, 13C-NMR, FTIR and Mass spectral data

Synthesis, SAR and antibacterial activity of hybrid chloro, dichloro-phenylthiazolyl-s-triazines

AbstractA series of hybrid novel chloro (1a–9a) and dichloro (10b–18b) phenylthiazolyl-s-triazine were synthesized and subsequently subjected to their antibacterial activity against three gram positive viz. Lactobacillus casei (NCIM-2651); Bacillus cereus (NCIM-2458); Staphylococcus aureus (NCIM-2120) and three gram negative viz Salmonella typhimurium (NCIM-2501); Escherichia coli (NCIM-2065); Klebsiella aerogenes (NCIM-2098). The SAR studies around the lead compound revealed that introduction of electron withdrawing groups and amino (–NH–) and mercapto (–S–) linker bridge seemed more promising towards antibacterial activity. Moreover, the virtual Molinspiration screenings are in compliance with Ghose’s rule

Physicochemical characterization and in vitro dissolution studies of solid dispersions of ketoprofen with PVP K30 and d-mannitol

AbstractAim of the present study was to improve the solubility and dissolution rate of poorly water soluble, BCS class-II drug Ketoprofen (KETO) by solid-dispersion approach. Solid dispersions were prepared by using polyvinylpyrrolidone K30 (PVP K30) and d-mannitol in different drugs to carrier ratios. Dispersions with PVP K30 were prepared by kneading and solvent evaporation techniques, whereas solid dispersions containing d-mannitol were prepared by kneading and melting techniques. These formulations were characterized in the liquid state by phase-solubility studies and in the solid state by Differential Scanning Calorimetry (DSC), Fourier Transform Infrared (FTIR) spectroscopy, X-ray diffraction (XRD) and Scanning Electron Microscopy (SEM). The aqueous solubility of KETO was favored by the presence of both carriers. The negative values of Gibbs free energy illustrate the spontaneous transfer from pure water to the aqueous polymer environment. Solid state characterization indicated KETO was present as fine particles in d-mannitol solid dispersions and entrapped in carrier matrix of PVP K30 solid dispersions. In contrast to the very slow dissolution rate of pure KETO, dispersions of drug in carriers considerably improved the dissolution rate. This can be attributed to increased wettability and dispersibility, as well as decreased crystallinity and increase in amorphous fraction of drug. Solid dispersions prepared with PVP K30 showed the highest improvement in dissolution rate of KETO. Even physical mixtures of KETO prepared with both carriers also showed better dissolution profiles than those of pure KETO

Synthesis and antibacterial activity of some 2,4,6-trisubstituted-1,3,5-triazines

A series of 2,4-bis(substitutedphenyl)-6-(4-(4-substitutedphenyl)thiazol-2-yl)-1,3,5-triazine- 2,4,6-triamine were synthesised, characterised by FT-IR, 1H NMR, 13C NMR, mass and elemental analysis and evaluated for in vitro antibacterial activity against three gram positive and gram negative bacteria by disk diffusion test and agar dilution technique with reference to streptomycin as standard. The antibacterial data revealed that compounds 2,4-bis(substitutedphenyl)-6-(4-(4-nitrophenyl)thiazol-2-yl)-1,3,5-triazine- 2,4,6-triamine had significant activity against the tested gram negative organism in reference to standard. However, these were nearly inactive against gram positive organisms.Colegio de Farmacéuticos de la Provincia de Buenos Aire

Synthesis and antibacterial activity of some 2,4,6-trisubstituted-1,3,5-triazines

A series of 2,4-bis(substitutedphenyl)-6-(4-(4-substitutedphenyl)thiazol-2-yl)-1,3,5-triazine- 2,4,6-triamine were synthesised, characterised by FT-IR, 1H NMR, 13C NMR, mass and elemental analysis and evaluated for in vitro antibacterial activity against three gram positive and gram negative bacteria by disk diffusion test and agar dilution technique with reference to streptomycin as standard. The antibacterial data revealed that compounds 2,4-bis(substitutedphenyl)-6-(4-(4-nitrophenyl)thiazol-2-yl)-1,3,5-triazine- 2,4,6-triamine had significant activity against the tested gram negative organism in reference to standard. However, these were nearly inactive against gram positive organisms.Colegio de Farmacéuticos de la Provincia de Buenos Aire