Testing spontaneous collapse through bulk heating experiments: estimate of the background noise

Models of spontaneous wave function collapse predict a small heating rate for a bulk solid, as a result of coupling to the noise field that causes collapse. This rate is small enough that ambient radioactivity and cosmic ray flux on the surface of the earth can mask the heating due to spontaneous collapse. In this paper we estimate the background noise due to gamma-radiation and cosmic ray muon flux, at different depths. We demonstrate that a low-temperature underground experiment at a depth of about 6.5 km.w.e. would have a low enough background to allow detection of bulk heating for a collapse rate $\lambda$ of $10^{-16}$ s$^{-1}$ using presently available technology.Comment: v3: 11 pages, 9 figures, parts of the paper rewritten, no change in results, to appear in Phys. Rev.

Laparoscopic Myomectomy Followed by Minilaparotomy for Management of a Large Submucous Fibroid

Background: We describe a patient with a single large type II submucous fibroid distorting and occupying the entire endometrial cavity, which was managed successfully with an approach less invasive than laparotomy. Case: The patient was a 36-year-old woman who presented with primary infertility of 2 years duration. Her associated complaints were menorrhagia and known uterine fibroids. She had undergone hysteroscopic myomectomy in the past without any improvement. An hysterosalpingogram revealed that the uterine cavity was occupied by a single large submucosal fibroid. Transvaginal ultrasound and saline infusion hysterosonogram showed a large anterior type II submucous, intramural, subserous fibroid. Diagnostic hysteroscopy and laparoscopy revealed a type II submucous fibroid occupying the entire anterior wall of the uterus. Laparoscopic myomectomy was performed and a fibroid measuring 8?cm was dissected. During the process, the endometrial cavity was entered and a minilaparotomy via a 5-cm transverse skin incision was performed to repair the endometrial cavity and overlying myometrium adequately and to remove the myoma. Results: Her postoperative course was uneventful. Six weeks later, saline infusion hysterosonogram revealed a uniform endometrial cavity with no filling defects or synechiae. Conclusions: Laparoscopic myomectomy with minilaparotomy is a safe, cost-effective, and less invasive approach for the treatment of patients with large type II submucous fibroids who want to preserve their reproductive potential. (J GYNECOL SURG 29:161)Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/140091/1/gyn.2012.0027.pd

Age at natural menopause and factors affecting its onset: A cross-sectional study among postmenopausal females in District Dehradun

Background: Menopause has become a popular topic of study as life expectancy rises around the world. The average age at menopause in both developed and developing countries ranges from 45 to 53 years. Factors influencing the extent of ovarian follicle reserve dwindling, such as sociodemographic, menstrual, reproductive, and dietary factors. Aim and Objective: The present study aimed to determine the mean age of menopause and to find out the various factors affecting menopause onset. Methods: A community based cross-sectional study conducted in rural and urban areas of District Dehradun for a period of 1 year starting 1st August 2020 to 31st July 2021. Data were collected using multistage stratified random sampling from 211 cases of natural menopause. Chi-square was applied as statistical test of significance and p < 0.05 was considered statistically significant. Results: According to current study, average age menopausal age is 46 years. Variables like sociodemographic characteristics, lifestyle habits, reproductive and menstrual factors were found to have a significant relationship with onset of menopause. Conclusion: Menopause, whether it occurs early or late in life, several factors are responsible for deciding its onset. As a result, it is critical to identify the factors influencing the onset of menopause

Sociodemographic Profile and Treatment-Seeking Behavior of HIV Infected Children Accessing Care at Pediatric ART Clinic of a Tertiary Care Hospital in Delhi

Background: Acquired immunodeficiency syndrome (AIDS) has emerged as one of the most serious public health problems in India. The parents of HIV-infected children are more likely to die and thus render the children orphan. The sociodemographic characteristics of children with HIV infection are different than the other children of the same age group. With the diverse range of manifestations, the symptoms of HIV/AIDS can appear in children at any time during the course of infection. After appearance of various signs/symptoms, the parents wander to various health agencies for relief and thus lose their vital time.Aims: The present study was conducted (1) to study the sociodemographic profile of children living with HIV/AIDS and (2) to know the treatment-seeking behavior of HIV/AIDS patients before coming to the tertiary hospital.Materials and Methods: The study was a hospital-based cross-sectional study where 216 children registered at the pediatric ART clinic of a tertiary care hospital in Delhi and their caregivers were included in the study. Semi-structured, pretested interview schedule was used for data collection through face-to-face interviews.Results: Out of the 216 children, males outnumbered females in the ratio of 2.48:1. Most of the children were in the age group of 10–14 years (48.1%) and the majority belonged to urban areas (63.4%). Most of the children were going to school. Majority of children (46.3%) belonged to social class-4. Hospitals (62.5%) were consulted first followed by private practitioners (33.3%) by these patients after appearance of earliest symptoms. Presenting symptoms of HIV in children were not specific and the most common symptom was fever (79.1%) followed by not gaining weight (69.4%), recurrent diarrhea (65.3%), cough (41.7%) and vomiting (30.6%). The average number of consultations sought by these patients before coming to this hospital was 2.34 per patients. Hospitals (39.8%) and prior experience at same hospital (33.3%) were the most common source of information about the ART center.

Expression of epithelial calcium transport system in rat cochlea and vestibular labyrinth

<p>Abstract</p> <p>Background</p> <p>The low luminal Ca²⁺concentration of mammalian endolymph in the inner ear is required for normal hearing and balance. We recently reported the expression of mRNA for a Ca²⁺-absorptive transport system in primary cultures of semicircular canal duct (SCCD) epithelium.</p> <p>Results</p> <p>We now identify this system in native vestibular and cochlear tissues by qRT-PCR, immunoblots and confocal immunolocalization. Transcripts were found and quantified for several isoforms of epithelial calcium channels (TRPV5, TRPV6), calcium buffer proteins (calbindin-D9K, calbindin-D28K), sodium-calcium exchangers (NCX1, NCX2, NCX3) and plasma membrane Ca²⁺-ATPase (PMCA1, PMCA2, PMCA3, and PMCA4) in native SCCD, cochlear lateral wall (LW) and stria vascularis (SV) of adult rat as well as Ca²⁺channels in neonatal SCCD. All components were expressed except TRPV6 in SV and PMCA2 in SCCD. 1,25-(OH)₂vitamin D₃(VitD) significantly up-regulated transcripts of TRPV5 in SCCD, calbindin-D9K in SCCD and LW, NCX2 in LW, while PMCA4 in SCCD and PMCA3 in LW were down-regulated. The expression of TRPV5 relative to TRPV6 was in the sequence SV > Neonatal SCCD > Adult SCCD > LW > primary culture SCCD. Expression of TRPV5 protein from primary culture of SCCD did not increase significantly when cells were incubated with VitD (1.2 times control; P > 0.05). Immunolocalization showed the distribution of TRPV5 and TRPV6. TRPV5 was found near the apical membrane of strial marginal cells and both TRPV5 and TRPV6 in outer and inner sulcus cells of the cochlea and in the SCCD of the vestibular system.</p> <p>Conclusions</p> <p>These findings demonstrate for the first time the expression of a complete Ca²⁺absorptive system in native cochlear and vestibular tissues. Regulation by vitamin D remains equivocal since the results support the regulation of this system at the transcript level but evidence for control of the TRPV5 channel protein was lacking.</p

Pharmacological Modulation of Photoreceptor Outer Segment Degradation in a Human iPS Cell Model of Inherited Macular Degeneration

Degradation of photoreceptor outer segments (POS) by retinal pigment epithelium (RPE) is essential for vision, and studies have implicated altered POS processing in the pathogenesis of some retinal degenerative diseases. Consistent with this concept, a recently established hiPSC-RPE model of inherited macular degeneration, Best disease (BD), displayed reduced rates of POS breakdown. Herein we utilized this model to determine (i) if disturbances in protein degradation pathways are associated with delayed POS digestion and (ii) whether such defect(s) can be pharmacologically targeted. We found that BD hiPSC-RPE cultures possessed increased protein oxidation, decreased free-ubiquitin levels, and altered rates of exosome secretion, consistent with altered POS processing. Application of valproic acid (VPA) with or without rapamycin increased rates of POS degradation in our model, whereas application of bafilomycin-A1 decreased such rates. Importantly, the negative effect of bafilomycin-A1 could be fully reversed by VPA. The utility of hiPSC-RPE for VPA testing was further evident following examination of its efficacy and metabolism in a complementary canine disease model. Our findings suggest that disturbances in protein degradation pathways contribute to the POS processing defect observed in BD hiPSC-RPE, which can be manipulated pharmacologically. These results have therapeutic implications for BD and perhaps other maculopathies

Genetic Affinities of the Central Indian Tribal Populations

Background: The central Indian state Madhya Pradesh is often called as ‘heart of India ’ and has always been an important region functioning as a trinexus belt for three major language families (Indo-European, Dravidian and Austroasiatic). There are less detailed genetic studies on the populations inhabited in this region. Therefore, this study is an attempt for extensive characterization of genetic ancestries of three tribal populations, namely; Bharia, Bhil and Sahariya, inhabiting this region using haploid and diploid DNA markers. Methodology/Principal Findings: Mitochondrial DNA analysis showed high diversity, including some of the older sublineages of M haplogroup and prominent R lineages in all the three tribes. Y-chromosomal biallelic markers revealed high frequency of Austroasiatic-specific M95-O2a haplogroup in Bharia and Sahariya, M82-H1a in Bhil and M17-R1a in Bhil and Sahariya. The results obtained by haploid as well as diploid genetic markers revealed strong genetic affinity of Bharia (a Dravidian speaking tribe) with the Austroasiatic (Munda) group. The gene flow from Austroasiatic group is further confirmed by their Y-STRs haplotype sharing analysis, where we determined their founder haplotype from the North Munda speaking tribe, while, autosomal analysis was largely in concordant with the haploid DNA results. Conclusions/Significance: Bhil exhibited largely Indo-European specific ancestry, while Sahariya and Bharia showed admixed genetic package of Indo-European and Austroasiatic populations. Hence, in a landscape like India, linguistic labe

Queer In AI: A Case Study in Community-Led Participatory AI

We present Queer in AI as a case study for community-led participatory design in AI. We examine how participatory design and intersectional tenets started and shaped this community's programs over the years. We discuss different challenges that emerged in the process, look at ways this organization has fallen short of operationalizing participatory and intersectional principles, and then assess the organization's impact. Queer in AI provides important lessons and insights for practitioners and theorists of participatory methods broadly through its rejection of hierarchy in favor of decentralization, success at building aid and programs by and for the queer community, and effort to change actors and institutions outside of the queer community. Finally, we theorize how communities like Queer in AI contribute to the participatory design in AI more broadly by fostering cultures of participation in AI, welcoming and empowering marginalized participants, critiquing poor or exploitative participatory practices, and bringing participation to institutions outside of individual research projects. Queer in AI's work serves as a case study of grassroots activism and participatory methods within AI, demonstrating the potential of community-led participatory methods and intersectional praxis, while also providing challenges, case studies, and nuanced insights to researchers developing and using participatory methods.Comment: To appear at FAccT 202