Book Centered to User Centered Librarianship

The development of Information and Communication Technologies and its application in Library and Information Science centers has changed the nature of collections; the needs of users; the library environment and the roles of LIS professionals. The old concept of Book-centered librarianship is changed to the User-centered librarianship. The ICT technologies have paved path to new roles to LIS professionals. The LIS professionals as Creators, Communicators, Leaders, Mentors, and Life-long learners are monitoring the trends in technology continuously to provide global information instantaneously to end-users through ICTs

Book Centered to User Centered Librarianship

The development of Information and Communication Technologies and its application in Library and Information Science centers has changed the nature of collections; the needs of users; the library environment and the roles of LIS professionals. The old concept of Book-centered librarianship is changed to the User-centered librarianship. The ICT technologies have paved path to new roles to LIS professionals. The LIS professionals as Creators, Communicators, Leaders, Mentors, and Life-long learners are monitoring the trends in technology continuously to provide global information instantaneously to end-users through ICTs

Frequency and management of gestational diabetes mellitus according to the new diabetes in pregnancy study group of India guidelines among Sikkimese women attending tertiary teaching hospital of East Sikkim

Background: The screening of GDM is important as various pregnancy related complications are associated to it. With early screening and diagnosis, the complications associated with GDM can be reduced. Studies have shown various ethnic groups are at increasing risk of developing GDM with prevalence differing in different ethnicity. No data is available about frequency of GDM in different ethnic women of Sikkim. This study was performed to determine the frequency of GDM and its variation according to different demographic profiles of Sikkimese women.Methods: Pregnant women between 16-34 weeks of gestation, attending antenatal OPD were included for this study. All the patients were subjected to DIPSI recommended 75 gm oral glucose tolerance test. Diagnosis of impaired glucose tolerance was made when plasma glucose of ≥120-140 mg/dl and diagnosis of GDM was made when the plasma glucose of >140 mg/dl as per DIPSI guidelines.Results: A total of 202 consenting pregnant women during 16-34 weeks of pregnancy were evaluated with DIPSI recommended 75 g oral glucose tolerance test. Overall frequency of GDM was 11.9% among the Sikkimese women while 10.9% had impaired results in OGTT.Conclusions: Frequency of GDM was high (12%) in pregnant women attending tertiary hospital of Sikkim. This implies Sikkimese women should be universally screened for GDM. There was also high occurrence of GDM among Lepcha and Bhutia women which need further study to find out the contributing factors in these women

Monostotic craniofacial fibrous dysplasia: report of two cases with interesting histology

Fibrous dysplasia (FD) is a relatively rare osseous disease of unknown etiology, wherein the normal bone is replaced by collagen-rich tissue, comprising of fibroblasts and variably abundant immature woven bone. Clinically, it may involve a single bone or multiple bones. It commonly arises in the jaw bone, skull, rib, and proximal femur. Those arising in the skull and the jaw are together termed “craniofacial fibrous dysplasia.” The differential diagnosis at this location includes meningioma and metastatic carcinoma. In this report, we highlight two diagnostically challenging cases presenting with orbital swelling and headache as the main complaints. Our first case was misinterpreted as meningioma on intraoperative squash smear, and paraffin sections revealed characteristic features of FD. The second case highlights the morphological feature of non-specific cystic degeneration occurring in FD. Radiographs in such cases show cystic swelling, which is indicative of a secondary aneurysmal bone cyst

Smart ungual biopenetrant from the roots of Beta vulgaris

The main objective of the current research was to isolate biopenetrant from Beta vulgaris and formulate bioadhesive layers loaded with terbinafine using this biopenetrant for delivery through nail. Form the preparation of films, Rosa centifolia and Vitis vinifera were used as a biopolymer. Beta vulgaris was used as biopenetrant. The formulations prepared using Beta vulgaris biopenetrant were compared with formulations containing papain as standard penetrant. Four bio-adhesive films of different ratios were prepared by film casting method using each penetrant. The formulated films were evaluated for various parameters like weight, thickness, nail adhesivity, content uniformity, surface pH, folding endurance, and in-vitro drug permeation. The formulation LB4 (containing 1:4 Beta vulgaris biopenetrant) was found to be the best formulation having R2 value 0.990 with zero order as best fit model. The results obtained conclude that biopenetrants can be used as natural penetration enhancer

Seasonal variation in semen quality: effect of temperature: a study in North India

Background: Variable temperature in different seasons may affect the quality of semen. Most of the studies are from west barring a single large Chinese study with variable results; however, no such study focusing on temperature alone has been published from Indian subcontinent. Present study was undertaken to observe any seasonal variation affecting the semen quality at different times of year.Methods: The study was conducted retrospectively over one year period (2014-2015) at a tertiary care hospital in North India. 815 semen samples referred from infertility clinic were analysed for Sperm concentration, functional sperm concentration, motile sperm concentration and sperm motility index by an automated semen analyser system (SQAIIC-P, Medical Electronic Systems, Los Angeles, CA, USA); and morphological assessment by Papanicolaou stained smears. Statistical analysis was done using SPSS 24 software (SPSS Inc, Chicago, IL, USA). The ANOVA test was used to assess differences in semen parameters, p30°C.There was significant variation on different parameters e.g. sperm count, motility, FSC, MSC, SMI, abnormal sperms and morphological defects when compared in different groups using ANOVA test (p<0.05).Conclusions: Present study observed that AHT of 20-30°C (autumn) has a favourable effect on semen quality; however, larger and continuous data in the form of longitudinal study is needed for better correlation

Correlation of functional results of caudal epidural steroid injections with duration of symptoms in PIVD

Background: Low backache and sciatica is a common complaint signifying some underlying pathology; it may be a soft tissue strain or disc protrusion, or conditions such as neoplasm or ankylosing spondylitis besides others. We aim to assess the functional outcome of epidural steroid injection in patients with low backache and sciatica as well as the effect of pre operative duration of symptoms in Indian population presenting to our centre, on the post procedure outcome, if any.Methods: 50 patients were evaluated with complaints of low backache and radiculopathy. They were subjected to following questionnaires including the ODI and VAS, and the scores were evaluated before and after the intervention, and at every follow up.Results: Patients commonly affected were from 4th and 5th decade. The commonest intervertebral disc involved was L4-5 (44%) followed by L5-S1 (30%). Significant Functional status improvement according to ODI scoring was observed in all follow up visits. Similarly significant reduction in pain intensity according to VAS scoring was observed in all follow up visits. On comparing the improvement in functional status (ODI) and pain (VAS) between the 3 groups, it is seen that patients in group A had the highest rate of improvement, while patients in group C had the least improvement.Conclusions: Caudal epidural injections are safe, effective and less expensive modality of treatment without any significant complications. The lesser the duration of symptoms i.e. earlier the patient presents, better are the results with caudal epidural injection.

Taxonomic revision of the Genus Pieris Schrank (Lepidoptera: Pieridae) from India

The genus Pieris Schrank popularly called as garden whites are economically important species of family Pireridae, comprise 35 species world over and in India is represented by nine species. In the present manuscript, six species of genus Pieris Schrank i.e., i.e. P. brassicae (Linnaeus), P. canidia (Linnaeus), &nbsp;P. deota (de Niceville), &nbsp;P. extensa&nbsp; Poujade, P. melete Menetries and P. rapae (Linnaeus) have been treated taxonomically from India. Besides studying morphological characters, their male and female genitalia have been described in details and illustrated for the first time. The diagnosis of the genus and key to species has been updated using genitalic attributes. In the study of genitalia, it has been observed that in the male genitalia of the genus Pieris the uncus is undivided and aedeagus is short and thick, whereas in the female genitalia the signum is bifid and appendix bursae are well developed. In the present work, the male genitalia of scheduled species P. deota has been studied and illustrated for the first time. The male and female genitalia of dry season forms and wet season forms of species P. melete, and the subspecies and polymorphic forms of species P. canidia have been studied and compared. It has been observed that in all forms there were no genitalic variations within the species

INVESTIGATING THE POTENTIAL OF AN ANTIDEPRESSANT INTRANASAL MUCOADHESIVE MICROEMULSION

Objective: The main aim of this study was to formulate, develop and optimized a duloxetine hydrochloride (dlx-hcl) loaded mucoadhesive microemulsion intended for intranasal administration.Methods: Established on solubility studies capmul mcm, transcutol-p, labrasol were used as oil, co-surfactant and surfactant respectively. The optimized mucoadhesive microemulsion prepared using water titration method was further characterized for particle size, polydispersity index, zeta potential and conductivity measurements followed by drug content, nasal cilio toxicity and biochemical estimation of the selected formulation.Results: All physicochemical parameters conducted, proved that dlx-hcl microemulsion was appropriate for nasal delivery. Chitosan, used as mucoadhesive polymer demonstrated enhanced retention time of the microemulsion in nasal mucosa with no signs of toxicity and epithelial damage. The particle size and zeta potential were found to be of 200 nm and-15 mV respectively considering the formulation safe for nasal delivery.Conclusion: This formulation strategy can be used as an effective targeting technique for the drugs having low bioavailability and poor brain penetration along with an effective method for the treatment long-term disease like depression