Assessment of Improved Tef (Eragrostis tef L.) Varieties for Yield and Yield Related Traits at Nono Benja and Cheliya Districts, Oromia, Ethiopia

Tef (Eragrostis tef) is one of the most important and strategic cereal crop grown to drought prone areas of Ethiopia. Genetic variability, genotypic correlations and yield components are prerequisite for selection of crop breeding, cultivation of improved varieties that provides optimum seed yield is one of the major constraints of the crop. The present study was aimed to investigate the adaptive and best performing tef varieties based on their yield and related traits under rain fed conditions at Nono Benja and Celia districts in Ethiopia. The experiment was conducted by using split plot design with three replications, sixteen improved varieties and one local landrace. The combined analysis of variance revealed that varieties were significantly different for studied characters except panicle length, total tiller number and spikelet length. The mean yields of nine improved  varieties (Dukem, Asgori, Tesfa, Negus, Quncho, Kora, Koye, Boset and key tena) were relatively higher than the local check comparing with mean values of grain yield ranged from Welkomi (372.08 kg/ ha) to Dukem (1315.41 kg/ ha).Grain yields were studied high in four varieties across two locations were (Dukem (1315.4 kg/ ha), asgori (1279.6 kg/ ha), Tesfa (1206.02 kg/ ha), Negus (1072.61 kg/ ha) with 72.8%, 68.2%, 58.5 %, and 41% over local check. The genotypic coefficient variation was observed that from 4.6% to 82.9% for loading index and the phenotypic coefficient variation range from 5.8% to 91.0% for loading index at Cheliya, respectively, the fertilizer application (0, 60/40 P/N kgha-1) showed highly differences among all traits except in GFP, PH and TGW traits. The varieties Gibe, Koye, Boset, Gimbichu, Enat and Kora were observed highly strong association with the environment, similarly Asgori and Gedo varieties were showed highly significant and strong connection with the environment Nono Benja with fertilization. Results reveal that the correlation studies provide a better understanding of yield components during the selection of tef genotypes

Assessment of Improved Tef (Eragrostis tef L.) Varieties for Yield and Yield Related Traits at Nono Benja and Cheliya Districts, Oromia, Ethiopia

Tef (Eragrostis tef) is one of the most important and strategic cereal crop grown to drought prone areas of Ethiopia. Genetic variability, genotypic correlations and yield components are prerequisite for selection of crop breeding, cultivation of improved varieties that provides optimum seed yield is one of the major constraints of the crop. The present study was aimed to investigate the adaptive and best performing tef varieties based on their yield and related traits under rain fed conditions at Nono Benja and Celia districts in Ethiopia. The experiment was conducted by using split plot design with three replications, sixteen improved varieties and one local landrace. The combined analysis of variance revealed that varieties were significantly different for studied characters except panicle length, total tiller number and spikelet length. The mean yields of nine improved  varieties (Dukem, Asgori, Tesfa, Negus, Quncho, Kora, Koye, Boset and key tena) were relatively higher than the local check comparing with mean values of grain yield ranged from Welkomi (372.08 kg/ ha) to Dukem (1315.41 kg/ ha).Grain yields were studied high in four varieties across two locations were (Dukem (1315.4 kg/ ha), asgori (1279.6 kg/ ha), Tesfa (1206.02 kg/ ha), Negus (1072.61 kg/ ha) with 72.8%, 68.2%, 58.5 %, and 41% over local check. The genotypic coefficient variation was observed that from 4.6% to 82.9% for loading index and the phenotypic coefficient variation range from 5.8% to 91.0% for loading index at Cheliya, respectively, the fertilizer application (0, 60/40 P/N kgha-1) showed highly differences among all traits except in GFP, PH and TGW traits. The varieties Gibe, Koye, Boset, Gimbichu, Enat and Kora were observed highly strong association with the environment, similarly Asgori and Gedo varieties were showed highly significant and strong connection with the environment Nono Benja with fertilization. Results reveal that the correlation studies provide a better understanding of yield components during the selection of tef genotypes

Limonene and BEZ 235 induce apoptosis in COLO-320 and HCT-116 colon cancer cells

Deregulated apoptosis is the hall mark of many cancers, therefore every defect in apoptosis pathway could be a potential target for cancer treatment.The anticancer mechanism of limonene could be multifactorial. However, induction of apoptosis in cancer cells is proposed as the predominant mechanism in several of preclinical studies. Therefore, we determined to investigate the role of apoptosis in the anticancer activity of limonene and BEZ235 combination in COLO-320 and HCT-116 colon cancer cells. Cells after treatments were assessed for apoptosis by DAPI staining for fluorescent microscopic examination of apoptotic cells, estimation of caspases activities, Bcl-2 family proteins in addition to cell cycle analysis by flowcytometry. Results show that both drugs induced apoptosis as demonstrated by increased caspases activity, significant alterations in pro and anti-apoptotic proteins of Bcl-2 family in promoting apoptosis and cell cycle arrest at G1 phase. Over all, it is indicated that limonene and BEZ exerted anticancer activity is mediated through induction of apoptosis involving mitochondria mediated intrinsic death pathway in the selected CRC cells

Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas

This integrated, multiplatform PanCancer Atlas study co-mapped and identified distinguishing molecular features of squamous cell carcinomas (SCCs) from five sites associated with smokin

Search for new physics in multijet events with at least one photon and large missing transverse momentum in proton-proton collisions at 13 TeV

A search for new physics in final states consisting of at least one photon, multiple jets, and large missing transverse momentum is presented, using proton-proton collision events at a center-of-mass energy of 13 TeV. The data correspond to an integrated luminosity of 137 fb−1, recorded by the CMS experiment at the CERN LHC from 2016 to 2018. The events are divided into mutually exclusive bins characterized by the missing transverse momentum, the number of jets, the number of b-tagged jets, and jets consistent with the presence of hadronically decaying W, Z, or Higgs bosons. The observed data are found to be consistent with the prediction from standard model processes. The results are interpreted in the context of simplified models of pair production of supersymmetric particles via strong and electroweak interactions. Depending on the details of the signal models, gluinos and squarks of masses up to 2.35 and 1.43 TeV, respectively, and electroweakinos of masses up to 1.23 TeV are excluded at 95% confidence level

Observation of the Rare Decay of the η Meson to Four Muons

A search for the rare η→μ+μ−μ+μ− double-Dalitz decay is performed using a sample of proton-proton collisions, collected by the CMS experiment at the CERN LHC with high-rate muon triggers during 2017 and 2018 and corresponding to an integrated luminosity of 101  fb−1. A signal having a statistical significance well in excess of 5 standard deviations is observed. Using the η→μ+μ− decay as normalization, the branching fraction B(η→μ+μ−μ+μ−)=[5.0±0.8(stat)±0.7(syst)±0.7(B2μ)]×10−9 is measured, where the last term is the uncertainty in the normalization channel branching fraction. This work achieves an improved precision of over 5 orders of magnitude compared to previous results, leading to the first measurement of this branching fraction, which is found to agree with theoretical predictions

Measurements of inclusive and differential cross sections for the Higgs boson production and decay to four-leptons in proton-proton collisions at s \sqrt{s} = 13 TeV

Measurements of the inclusive and differential fiducial cross sections for the Higgs boson production in the H → ZZ → 4ℓ (ℓ = e, μ) decay channel are presented. The results are obtained from the analysis of proton-proton collision data recorded by the CMS experiment at the CERN LHC at a center-of-mass energy of 13 TeV, corresponding to an integrated luminosity of 138 fb−1. The measured inclusive fiducial cross section is 2.73 ± 0.26 fb, in agreement with the standard model expectation of 2.86 ± 0.1 fb. Differential cross sections are measured as a function of several kinematic observables sensitive to the Higgs boson production and decay to four leptons. A set of double-differential measurements is also performed, yielding a comprehensive characterization of the four leptons final state. Constraints on the Higgs boson trilinear coupling and on the bottom and charm quark coupling modifiers are derived from its transverse momentum distribution. All results are consistent with theoretical predictions from the standard model

First measurement of the top quark pair production cross section in proton-proton collisions at s \sqrt{s} = 13.6 TeV

The first measurement of the top quark pair (tt¯) production cross section in proton-proton collisions at s√ = 13.6 TeV is presented. Data recorded with the CMS detector at the CERN LHC in Summer 2022, corresponding to an integrated luminosity of 1.21 fb−1, are analyzed. Events are selected with one or two charged leptons (electrons or muons) and additional jets. A maximum likelihood fit is performed in event categories defined by the number and flavors of the leptons, the number of jets, and the number of jets identified as originating from b quarks. An inclusive tt¯ production cross section of 881 ± 23 (stat + syst) ± 20 (lumi) pb is measured, in agreement with the standard model prediction of 924+32−40 pb