357 research outputs found
Predicting the dispersal of SARS-CoV-2 RNA from the wastewater treatment plant to the coast
Viral pathogens including SARS-CoV-2 RNA have been detected in wastewater treatment effluent, and untreated sewage overflows, that pose an exposure hazard to humans. We assessed whether SARS-CoV-2 RNA was likely to have been present in detectable quantities in UK rivers and estuaries during the first wave of the Covid-19 pandemic. We simulated realistic viral concentrations parameterised on the Camel and Conwy catchments (UK) and their populations, showing detectable SARS-CoV-2 RNA concentrations for untreated but not for treated loading, but also being contingent on viral decay, hydrology, catchment type/shape, and location. Under mean or low river flow conditions, viral RNA concentrated within the estuaries allowing for viral build-up and caused a lag by up to several weeks between the peak in community infections and the viral peak in the environment. There was an increased hazard posed by SARS-CoV-2 RNA with a T90 decay rate >24 h, as the estuarine build-up effect increased. High discharge events transported the viral RNA downstream and offshore, increasing the exposure risk to coastal bathing waters and shellfisheries â although dilution in this case reduced viral concentrations well below detectable levels. Our results highlight the sensitivity of exposure to viral pathogens downstream of wastewater treatment, across a range of viral loadings and catchment characteristics â with implications to environmental surveillance
Flux Phase as a Dynamic Jahn-Teller Phase: Berryonic Matter in the Cuprates?
There is considerable evidence for some form of charge ordering on the
hole-doped stripes in the cuprates, mainly associated with the low-temperature
tetragonal phase, but with some evidence for either charge density waves or a
flux phase, which is a form of dynamic charge-density wave. These three states
form a pseudospin triplet, demonstrating a close connection with the E X e
dynamic Jahn-Teller effect, suggesting that the cuprates constitute a form of
Berryonic matter. This in turn suggests a new model for the dynamic Jahn-Teller
effect as a form of flux phase. A simple model of the Cu-O bond stretching
phonons allows an estimate of electron-phonon coupling for these modes,
explaining why the half breathing mode softens so much more than the full
oxygen breathing mode. The anomalous properties of provide a coupling
(correlated hopping) which acts to stabilize density wave phases.Comment: Major Revisions: includes comparisons with specific cuprate phonon
modes, 16 eps figures, revte
A New Approach to Background Subtraction in Low-Energy Neutrino Experiments
We discuss a new method to extract neutrino signals in low energy
experiments. In this scheme the symmetric nature of most backgrounds allows for
direct cancellation from data. The application of this technique to the Palo
Verde reactor neutrino oscillation experiment allowed us to reduce the
measurement errors on the anti-neutrino flux from % to %. We
expect this method to substantially improve the data quality in future low
background experiments such as KamLAND and LENS.Comment: 7 pages, 2 figure
Isospin Violation in Chiral Perturbation Theory and the Decays \eta \ra \pi \ell \nu and \tau \ra \eta \pi \nu
I discuss isospin breaking effects within the standard model. Chiral
perturbation theory presents the appropriate theoretical framework for such an
investigation in the low--energy range. Recent results on the electromagnetic
contributions to the masses of the pseudoscalar mesons and the
amplitudes are reported. Using the one--loop formulae for the
form factors, rather precise predictions for the decay rates of can be obtained. Finally, I present an estimate of
the \tau \ra \eta \pi \nu branching ratio derived from the dominant meson
resonance contributions to this decay.Comment: 10 pages, latex, one figure available upon reques
Recommendations for NextâGeneration Ground Magnetic Perturbation Validation
Dataâmodel validation of ground magnetic perturbation forecasts, specifically of the time rate of change of surface magnetic field, dB/dt, is a critical task for model development and for mitigation of geomagnetically induced current effects. While a current, communityâaccepted standard for dB/dt validation exists (Pulkkinen et al., 2013), it has several limitations that prevent more complete understanding of model capability. This work presents recommendations from the International Forum for Space Weather Capabilities Assessment Ground Magnetic Perturbation Working Team for creating a nextâgeneration validation suite. Four recommendations are made to address the existing suite: greatly expand the number of ground observatories used, expand the number of events included in the suite from six to eight, generate metrics as a function of magnetic local time, and generate metrics as a function of activity type. For each of these, implementation details are explored. Limitations and future considerations are also discussed.Plain Language SummarySpace weather forecast models of magnetic field perturbations are important for protecting the power grid and other vulnerable infrastructure. These models must be validated by comparing their predictions to observations. This paper makes recommendations for how future models should be validated in order to best test their capabilities.Key PointsWe present a new validation suite for models of ground magnetic perturbations, dB/dt, of interest for geomagnetically induced currentsThe existing standard remains useful but provides limited information, so an expanded set of metrics is defined hereThis work is a result of the International Forum for Space Weather Capabilities Assessment and represents a new community consensusPeer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/147786/1/swe20777_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/147786/2/swe20777.pd
Upper critical field for underdoped high-T_c superconductors. Pseudogap and stripe--phase
We investigate the upper critical field in a stripe--phase and in the
presence of a phenomenological pseudogap. Our results indicate that the
formation of stripes affects the Landau orbits and results in an enhancement of
. On the other hand, phenomenologically introduced pseudogap leads to a
reduction of the upper critical field. This effect is of particular importance
when the magnitude of the gap is of the order of the superconducting transition
temperature. We have found that a suppression of the upper critical field takes
place also for the gap that originates from the charge--density waves.Comment: 7 pages, 5 figure
Rare Charm Decays in the Standard Model and Beyond
We perform a comprehensive study of a number of rare charm decays,
incorporating the first evaluation of the QCD corrections to the short distance
contributions, as well as examining the long range effects. For processes
mediated by the transitions, we show that sensitivity to
short distance physics exists in kinematic regions away from the vector meson
resonances that dominate the total rate. In particular, we find that
and are sensitive to non-universal
soft-breaking effects in the Minimal Supersymmetric Standard Model with
R-parity conservation. We separately study the sensitivity of these modes to
R-parity violating effects and derive new bounds on R-parity violating
couplings. We also obtain predictions for these decays within extensions of the
Standard Model, including extensions of the Higgs, gauge and fermion sectors,
as well as models of dynamical electroweak symmetry breaking.Comment: 45 pages, typos fixed, discussions adde
ReïŹning and regaining skills in ïŹxation/diversiïŹcation stage performers: The Five-A Model
Technical change is one of many factors underpinning success in elite, fixation/diversification stage performers. Surprisingly, however, there is a dearth of research pertaining to this process or the most efficacious methods used to bring about such a change. In this paper we highlight the emergent processes, yet also the lack in mechanistic comprehension surrounding technical change, addressing issues within the motor control, sport psychology, coaching and choking literature. More importantly, we seek an understanding of how these changes can be made more secure to competitive pressure, and how this can be embedded within the process of technical change. Following this review, we propose The Five-A Model based on successful coaching techniques, psychosocial concomitants, the avoidance of choking and principles of effective behaviour change. Specific mechanisms for each stage are discussed, with a focus on the use of holistic rhythm-based cues as a possible way of internalising changes. Finally, we suggest the need for further research to examine these five stages, to aid a more comprehensive construction of the content and delivery of such a programme within the applied setting
An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics
For a decade, The Cancer Genome Atlas (TCGA) program collected clinicopathologic annotation data along with multi-platform molecular profiles of more than 11,000 human tumors across 33 different cancer types. TCGA clinical data contain key features representing the democratized nature of the data collection process. To ensure proper use of this large clinical dataset associated with genomic features, we developed a standardized dataset named the TCGA Pan-Cancer Clinical Data Resource (TCGA-CDR), which includes four major clinical outcome endpoints. In addition to detailing major challenges and statistical limitations encountered during the effort of integrating the acquired clinical data, we present a summary that includes endpoint usage recommendations for each cancer type. These TCGA-CDR findings appear to be consistent with cancer genomics studies independent of the TCGA effort and provide opportunities for investigating cancer biology using clinical correlates at an unprecedented scale. Analysis of clinicopathologic annotations for over 11,000 cancer patients in the TCGA program leads to the generation of TCGA Clinical Data Resource, which provides recommendations of clinical outcome endpoint usage for 33 cancer types
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