Emotional disturbance in planned versus unplanned coloured children and their mothers

Twenty-nine planned and seventy-six unplanned Coloured children were compared on the Junior Eysenck Personality Inventory, the Purpose In Life test and the Rutter Teachers' Questionnaire for emotional disturbance. Their mothers were also compared on the Eysenck Personality Inventory for neuroticism and the Maryland Parent Attitude Survey. The Purpose In Life test showed the planned children to have significantly more meaning in their lives. No significant differences between planned and unplanned children were obtained on the other two questionnaires. Mothers of unplanned children were found to be significantly more neurotic than mothers of planned children. No differences in maternal attitudes of rejection and protection were found. Differences in the family size and educational attainment of the mothers were significant in the expected direction. It was finally postulated that the greater the adversity of circumstance of the family, the more negative the effects of unplanned status will be on emotional adjustment

Evaluation of in-situ shrinkage and expansion properties of polymer composite materials for adhesive anchor systems by a novel approach based on digital image correlation

The curing reaction of thermosetting resins is associated with chemical shrinkage which is overlapped with thermal expansion as a result of the exothermal enthalpy. Final material properties of the polymer are determined by this critical process. For adhesive anchor systems the overall shrinkage behavior of the material is very important for the ultimate bond behavior between adhesive and the borehole wall. An approach for the insitu measurement of 3-dimensional shrinkage and thermal expansion with digital image correlation (DIC) is presented, overcoming the common limitation of DIC to solids. Two polymer-based anchor systems (filled epoxy, vinylester) were investigated and models were developed, showing good agreement with experimental results. Additionally, measurements with differential scanning calorimetry (DSC) provided supporting information about the curing reaction. The vinylester system showed higher shrinkage but much faster reaction compared to the investigated epoxy

Assessing Competition in U.S. Wireless Markets: Review of the FCC’s Competition Reports

The FCC\u27s 14th and 15th Annual Wireless Competition reports review a wide variety of evidence, both direct (how firms and customers behave) and indirect (industry concentration measures) in making its competitive assessment. The reports are silent on how to interpret this evidence. In contrast, modem antitrust analysis relies far more on direct evidence. In failing to put more weight on the relevant direct market evidence to reach an informed competitive assessment, the 14th and 15th reports invite erroneous conclusions about the state of competition in wireless markets. The authors are concerned that these erroneous conclusions eventually could adversely influence regulatory policy in wireless markets. Before economists came to rely on direct measures of market power, they relied on indirect measures, such as market share in the relevant markets, the Herfindahl-Hirschman Index ( HHI ), and market definitions. The 14th and 15th reports downplayed direct evidence of competition-namely, aggressive pricing behavior, robust entry, and continued long-term reductions in price, all of which strongly support a conclusion of effective competition. Instead, the FCC focuses on inferences of market power based on market shares. To test the FCC\u27s presumed relationship between market structure and prices in the wireless industry, the authors analyzed the TNS Telecoms database of cellular telephone bills. The authors found no statistically significant relationship between a household\u27s monthly wireless bill and the HHI of the economic area in which the household resides. Thus, market concentration does not appear to have an impact on what the customer actually pays. This finding, along with the fact that wireless prices have declined over time as industry concentration has increased, undermines the structure-conduct hypothesis that undergirds the FCC\u27s market-share analysis

Generalized Stochastic Quantization of Yang-Mills Theory

We perform the stochastic quantization of Yang-Mills theory in configuration space and derive the Faddeev-Popov path integral density. Based on a generalization of the stochastic gauge fixing scheme and its geometrical interpretation this result is obtained as the exact equilibrium solution of the associated Fokker--Planck equation. Included in our discussion is the precise range of validity of our approach.Comment: 19 pages, Late

The Gcs1 and Age2 ArfGAP proteins provide overlapping essential function for transport from the yeast trans-Golgi network

Many intracellular vesicle transport pathways involve GTP hydrolysis by the ADP-ribosylation factor (ARF) type of monomeric G proteins, under the control of ArfGAP proteins. Here we show that the structurally related yeast proteins Gcs1 and Age2 form an essential ArfGAP pair that provides overlapping function for TGN transport. Mutant cells lacking the Age2 and Gcs1 proteins cease proliferation, accumulate membranous structures resembling Berkeley bodies, and are unable to properly process and localize the vacuolar hydrolase carboxypeptidase (CPY) and the vacuolar membrane protein alkaline phosphatase (ALP), which are transported from the TGN to the vacuole by distinct transport routes. Immunofluorescence studies localizing the proteins ALP, Kex2 (a TGN resident protein), and Vps10 (the CPY receptor for transport from the TGN to the vacuole) suggest that inadequate function of this ArfGAP pair leads to a fragmentation of TGN, with effects on secretion and endosomal transport. Our results demonstrate that the Gcs1 + Age2 ArfGAP pair provides overlapping function for transport from the TGN, and also indicate that multiple activities at the TGN can be maintained with the aid of a single ArfGAP

Metabolic Health Reduces Risk of Obesity-Related Cancer in Framingham Study Adults

Abstract Background: It is unknown whether the risk for obesity-related cancers differs between metabolically unhealthy and healthy overweight/obese adults. Methods: Data on body mass index (BMI), waist circumference (WC), waist-to-height ratio (WHtR), and random blood glucose in Framingham Heart Study adults (n ¼ 3,763) ages 55 to 69 years were used to estimate risks of obesity-related cancers (n ¼ 385), including postmenopausal breast, female reproductive, colon, liver, gallbladder, pancreas, and kidney cancers, as well as esophageal adenocarcinomas. Multivariable-adjusted Cox proportional hazards models were used to estimate risk for obesity-related cancers associated with body fat and metabolic health (as defined by glucose levels) among subjects in three risk groups (vs. referent group with normal weight/normal glucose): normal weight/elevated glucose, overweight/normal glucose, and overweight/elevated glucose. Results: Overweight adults [BMI 25 or WHtR 0.51 (men) and 0.57 (women)] with elevated glucose (125 mg/dL) had a statistically significant 2-fold increased risk of developing obesity-related cancer, whereas overweight adults with normal glucose had a 50% increased risk. Normal-weight adults with elevated glucose had no excess cancer risk. The effects of BMI and WHtR were independent of one another. Finally, overweight women with elevated blood glucose had a 2.6-fold increased risk [95% confidence interval (CI), 1.4-4.9] of female reproductive (cervical, endometrial, uterine cancers) and postmenopausal breast cancers, whereas overweight women with normal glucose levels had only a 70% increased risk (95% CI, 1.1-2.5). Conclusion: These results suggest that cancer risk may be lower among metabolically healthy overweight/ obese older adults than among overweight/obese adults with metabolic dysfunction. Impact: Metabolic dysfunction and obesity act synergistically to increase cancer risk. Cancer Epidemiol Biomarkers Prev; 23(10); 2057-65. Ó2014 AACR

The Aussie, 1918-1931: cartoons, digger remembrance and First World War identity

Feelings of community, cultural definition and memory were kept alive through the soldiers’ mass circulation tabloid, the Aussie, examined here in the light of theorization of memory and representation, applied to both text and cartoons. The publication’s aim for veterans’ values to become shared national values is analysed in the light of its high profile usage of soft cartoon humour and also of nostalgia – highlighting the limitations as well as the effectiveness in terms of Australia’s evolving national identity. When the post-war economic situation worsened, deeper issues of national tension were glossed over by the use of scapegoats such as ‘profiteers’ and ‘lazy workers’. The armed forces were obliged to take on a political role of lobbying for their cause, but the Aussie as ‘cheerful friend’ experienced its own identity crisis that proved to be terminal

Histone modifications and chromatin dynamics: a focus on filamentous fungi

The readout of the genetic information of eukaryotic organisms is significantly regulated by modifications of DNA and chromatin proteins. Chromatin alterations induce genome-wide and local changes in gene expression and affect a variety of processes in response to internal and external signals during growth, differentiation, development, in metabolic processes, diseases, and abiotic and biotic stresses. This review aims at summarizing the roles of histone H1 and the acetylation and methylation of histones in filamentous fungi and links this knowledge to the huge body of data from other systems. Filamentous fungi show a wide range of morphologies and have developed a complex network of genes that enables them to use a great variety of substrates. This fact, together with the possibility of simple and quick genetic manipulation, highlights these organisms as model systems for the investigation of gene regulation. However, little is still known about regulation at the chromatin level in filamentous fungi. Understanding the role of chromatin in transcriptional regulation would be of utmost importance with respect to the impact of filamentous fungi in human diseases and agriculture. The synthesis of compounds (antibiotics, immunosuppressants, toxins, and compounds with adverse effects) is also likely to be regulated at the chromatin level