Polarographic Studies of Cd(II) & Pb(II) Complexes with 2,3-Dihydroxypyridine

913-91

In silico Screening of Violacein as an epidermal growth factor receptor inhibitor

EGFR is a key player in the signalling cascades of various kinds of cancers and tyrosine kinase inhibitors block EGFR signalling. Natural products have long been used as candidates for therapy in the management of cancer. Violacein, a bacterial pigment, has been known for its numerous biological applications such as antimicrobial, antileishmanial, antiviral, as well as antitumoral. Computational studies have concluded that it may have activity against cancers like pancreatic cancer, thyroid cancer, colorectal cancer, and endometrial cancer indicating its potential application as a broad range of anti-cancerous drug. This study aimed to perform the molecular docking of violacein with the EGFR protein to ascertain its EGFR inhibitor property, which could lead to the development of a novel anti-cancer drug

केरल में एरणाकुलम जिला के तटीय गाँव में संस्थान- गाँव-संपर्क कार्यक्रम

कृपया पूरा लेखा पढ

L-deprenyl attenuates the rotenone-induced dopaminergic neurotoxicity: experimental evidences in rats

Parkinson disease (PD) is progressive neurological disorder because of massive degeneration of nigrostriatal dopaminergic neurons. The pathogenesis of PD is unknown, but considerable evidence suggests multifactorial factors including genetic, mitochondrial dysfunction, oxidative stress, excitotoxicity, calcium cytotoxicity, environmental factors and apoptosis. We investigated the role of oxidative damage produced by intranigral infusion of a potent mitochondrial complex-I inhibitor, rotenone and studied the neuroprotective effects with a well-known antiparkinsonian drug L-deprenyl in rats. Unilateral stereotaxic intranigral infusion of rotenone 6 lg caused significant decrease in dopamine levels. L-deprenyl (10 mg/kg) treatment significantly attenuated the DA depletion caused by rotenone. Parallely, a significant decrease in the concentration of GSH was also observed in the SN was reverted by L-deprenyl treatment. L-deprenyl significantly attenuated the rotenone-induced decrease in tyrosine hydroxylase immunoreactivity in striatum. The results suggest that L-deprenyl can rescue the dopaminergic neurons from the rotenone mediated neurodegeneration in this experimental animal model

മത്സ്യ മേഖലയിലെ വനിതാശാക്തീകരണം:എളംകുന്നപ്പുഴ മാതൃക. pp.27-31

മത്സ്യ മേഖലയിലെ വനിതാശാക്തീകരണം:എളംകുന്നപ്പുഴ മാതൃ

Comparison of performance parameters of poly(3,4 ethylenedioxythiophene) (PEDOT) based electrochromic device on glass with and without counter electrode

Conjugated polymers are promising materials for electrochromic device technology. Aqueous dispersions of poly(3,4-ethylenedioxythiophene)-(PEDOT) were spin coated onto transparent conducting oxide (TCO) coated glass substrates. A seven-layer electrochromic device was fabricated with the following configuration: glass/transparent conducting oxide (TCO)/PEDOT (main electrochromic layer)/gel electrolyte/prussian blue (counter electrode)/TCO/glass. The device fabricated with counter electrode (Prussian blue) showed a contrast of 18% and without counter electrode showed visible contrast of 5% at 632 nm at a voltage of 1·9 V. The comparison of the device is done in terms of the colouration efficiency of the devices with and without counter electrode

Efficient Circuit Configuration to Reduce Comparator Requirement of 8-Bit Flash Analog to Digital Convertor

Need constantly exists for converters with higher resolution, faster conversion speed and lower power dissipation. High-speed analog to digital converters (ADC’s) have been based on flash architecture, because all comparators sample the analog input voltage simultaneously, this ADC is thus inherently fast. Unfortunately, flash ADC requires 2N - 1 comparators to convert N bit digital code from an analog sample. This makes flash ADC’s unsuitable for high-resolution applications. This paper demonstrates a simple technique to reduce comparator requirement of 8-bit flash ADC that requires as few as 65 comparators for 8-bit conversion. In this approach, the analog input range is partitioned into 64 quantization cells, separated by 63 boundary points. A 6-bit binary code 000000 to 111111 is assigned to each cell. A 8-bit flash converter requires 256 comparators, while proposed technique reduces number of comparator requirements to 65 for 8-bit conversion. DOI: 10.17762/ijritcc2321-8169.150711

Marine Fisheries Profile Tamil Nadu (in Tamil)

Marine Fisheries Profile Tamil Nad