323 research outputs found
Separating Solution of a Quadratic Recurrent Equation
In this paper we consider the recurrent equation
for with and given. We give conditions
on that guarantee the existence of such that the sequence
with tends to a finite positive limit as .Comment: 13 pages, 6 figures, submitted to J. Stat. Phy
Structure of Quantum Chaotic Wavefunctions: Ergodicity, Localization, and Transport
We discuss recent developments in the study of quantum wavefunctions and
transport in classically ergodic systems. Surprisingly, short-time classical
dynamics leaves permanent imprints on long-time and stationary quantum
behavior, which are absent from the long-time classical motion. These imprints
can lead to quantum behavior on single-wavelength or single-channel scales
which are very different from random matrix theory expectations. Robust and
quantitative predictions are obtained using semiclassical methods. Applications
to wavefunction intensity statistics and to resonances in open systems are
discussed.Comment: 8 pages, including 2 figures; talk given at `Dynamics of Complex
Systems' workshop in Dresden, 1999 and submitted for conference proceedings
to appear in Physica
Entropy and the variational principle for actions of sofic groups
Recently Lewis Bowen introduced a notion of entropy for measure-preserving
actions of a countable sofic group on a standard probability space admitting a
generating partition with finite entropy. By applying an operator algebra
perspective we develop a more general approach to sofic entropy which produces
both measure and topological dynamical invariants, and we establish the
variational principle in this context. In the case of residually finite groups
we use the variational principle to compute the topological entropy of
principal algebraic actions whose defining group ring element is invertible in
the full group C*-algebra.Comment: 44 pages; minor changes; to appear in Invent. Mat
Effect of Tetramethylpyrazine on Atherosclerosis and SCAP/SREBP-1c Signaling Pathway in ApoE −/−
Lipid metabolism dysregulation plays a crucial role in the occurrence of atherosclerosis (As). SCAP/SREBP signaling is the main pathway for regulating lipid metabolism. Tetramethylpyrazine (TMP), a Traditional Chinese Medicine (TCM) for treating angina pectoris, has antiatherosclerotic effects and ameliorates blood lipids disturbance. However, its precise mechanism remains unclear. This study investigated the mechanism of TMP in ameliorating As in mice model. After six weeks of high-fat diet, 30 ApoE−/− mice were randomized (n=10) and treated with Lipitor, TMP, or distilled water for six weeks. The serum blood lipids and insulin levels were measured. The expressions of PAQR3, Insig-1, SCAP, SREBP-1c, IRS-1, PI3K, Akt, and mTORC-1 in the adipose tissues were determined. The results showed that TMP could significantly decrease blood lipids levels, insulin, and corrected plaque area of the ApoE−/− mice as compared to the untreated mice (P<0.05, P<0.01). Moreover, TMP could significantly downregulate the expressions of SCAP, SREBP-1c, PAQR3, IRS-1, PI3K, Akt, and mTORC1 (P<0.01). Thus, TMP may ameliorate lipid metabolism disorder and As by downregulating PAQR3 and inhibiting SCAP/SREBP-1c signaling pathway. In addition, PI3K/Akt/mTORC1 signaling pathway may be involved in this process
Spectral Statistics in the Quantized Cardioid Billiard
The spectral statistics in the strongly chaotic cardioid billiard are
studied. The analysis is based on the first 11000 quantal energy levels for odd
and even symmetry respectively. It is found that the level-spacing distribution
is in good agreement with the GOE distribution of random-matrix theory. In case
of the number variance and rigidity we observe agreement with the random-matrix
model for short-range correlations only, whereas for long-range correlations
both statistics saturate in agreement with semiclassical expectations.
Furthermore the conjecture that for classically chaotic systems the normalized
mode fluctuations have a universal Gaussian distribution with unit variance is
tested and found to be in very good agreement for both symmetry classes. By
means of the Gutzwiller trace formula the trace of the cosine-modulated heat
kernel is studied. Since the billiard boundary is focusing there are conjugate
points giving rise to zeros at the locations of the periodic orbits instead of
exclusively Gaussian peaks.Comment: 20 pages, uu-encoded ps.Z-fil
Level spacing statistics of classically integrable systems -Investigation along the line of the Berry-Robnik approach-
By extending the approach of Berry and Robnik, the limiting level spacing
distribution of a system consisting of infinitely many independent components
is investigated. The limiting level spacing distribution is characterized by a
single monotonically increasing function of the level spacing
. Three cases are distinguished: (i) Poissonian if ,
(ii) Poissonian for large , but possibly not for small if
, and (iii) sub-Poissonian if .
This implies that, even when energy-level distributions of individual
components are statistically independent, non-Poissonian level spacing
distributions are possible.Comment: 19 pages, 4 figures. Accepted for publication in Phys. Rev.
Shen-Yuan-Dan Capsule Attenuates Atherosclerosis and Foam Cell Formation by Enhancing Autophagy and Inhibiting the PI3K/Akt/mTORC1 Signaling Pathway
Background and Aim: The phosphoinositide 3-kinase (PI3K)/Akt/mammalian target of rapamycin complex 1 (mTORC1) signaling pathway plays a crucial role in autophagy and inflammation. Our previous studies demonstrated that Shen-Yuan-Dan Capsule (SYDC), a Chinese medicine used for treating angina pectoris, has anti-atherosclerotic and anti-inflammatory effects in mice. However, its effects on autophagy and the PI3K/Akt/mTORC1 signaling pathway remain unclear. This study aimed to explore the effects of SYDC on autophagy and PI3K/Akt/mTORC1 signaling in the apolipoprotein E knockout (ApoE−/−) mouse model and in macrophage-derived foam cells to delineate the underlying mechanism.Methods: After 6 weeks of high-fat diet, ApoE–/– mice were randomly grouped into control, Lipitor, low-SYDC (SYDC-L), middle-SYDC (SYDC-M), and high-SYDC (SYDC-H) groups (n = 10). The mice were intragastrically administered the respective treatment for 6 weeks. Murine RAW264.7 cells were stimulated with oxidized low-density lipoprotein (ox-LDL) (80 µg/ml) for 24 h and then pretreated with SYDC freeze-dried powder for another 24 h. Cells treated with SYDC were co-cultured for 24 h with LY294002, tricirbine, and rapamycin to investigate the effects on the PI3K/Akt/mTORC1 signaling pathway.Results: SYDC ameliorated blood lipid levels, reduced the atherosclerotic index and plaque areas in the aortic root in mice, and inhibited total cholesterol (TC) levels and cholinesterase (ChE)/TC ratios in ox-LDL stimulated macrophages. Moreover, SYDC up-regulated Beclin1 and LC3II/I proteins in mice and in the ox-LDL–stimulated macrophages. Moreover, SYDC inhibited AKT phosphorylation at Ser473 and mTOR phosphorylation at Ser2448 in mice and in ox-LDL–stimulated macrophages. Furthermore, SYDC’s inhibitory of ChE/TC ratios in ox-LDL–stimulated macrophages was not changed by selective inhibition of the PI3K/Akt/mTORC1 pathway.Conclusions: Our results highlight that SYDC treatment attenuates foam cell formation by promoting autophagy via inhibiting activation of the PI3K/Akt/mTORC1 signaling pathway. This study provides new insights into the molecular mechanism underlying SYDC’s therapeutic potential for treating atherosclerosis
Entire solutions of hydrodynamical equations with exponential dissipation
We consider a modification of the three-dimensional Navier--Stokes equations
and other hydrodynamical evolution equations with space-periodic initial
conditions in which the usual Laplacian of the dissipation operator is replaced
by an operator whose Fourier symbol grows exponentially as \ue ^{|k|/\kd} at
high wavenumbers . Using estimates in suitable classes of analytic
functions, we show that the solutions with initially finite energy become
immediately entire in the space variables and that the Fourier coefficients
decay faster than \ue ^{-C(k/\kd) \ln (|k|/\kd)} for any . The
same result holds for the one-dimensional Burgers equation with exponential
dissipation but can be improved: heuristic arguments and very precise
simulations, analyzed by the method of asymptotic extrapolation of van der
Hoeven, indicate that the leading-order asymptotics is precisely of the above
form with . The same behavior with a universal constant
is conjectured for the Navier--Stokes equations with exponential
dissipation in any space dimension. This universality prevents the strong
growth of intermittency in the far dissipation range which is obtained for
ordinary Navier--Stokes turbulence. Possible applications to improved spectral
simulations are briefly discussed.Comment: 29 pages, 3 figures, Comm. Math. Phys., in pres
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