Elusa. From Nabatean Trading Post to Late Antique Desert Metropolis: Results of the 2015−2020 Seasons

In Roman to late Byzantine times, Elusa (Hebrew: Haluza, Arabic: al-Khalasa) was the most important settlement in the Negev region and its only proper city. Identified in 1838 by E. Robinson, it was subsequently visited by numerous researchers. The most important investigations took place in the form of surveys and excavations from the 1970s until 2001, during which, among other things, the only theatre in the region and the city’s cathedral were uncovered. However, despite several research projects, very basic information on the city and its genesis, history and structure has been lacking until now. Since 2015, this has been the focus of an international cooperation project that is investigating these fundamental questions using a multi-method approach. The focus here is also on the role of the city in the region, as it appears as an economic, administrative, cultural and religious centre. Particular emphasis is placed on the city’s flourishing in light of its precarious natural location within the Negev Desert. The article reflects the combined findings of remote sensing, archaeological survey, geophysical prospection, targeted excavations, geochemical soil sampling and extensive find material analyses and thus provides an unprecedented insight into the character and development of ancient Elusa.In Roman to late Byzantine times, Elusa (Hebrew: Haluza, Arabic: al-Khalasa) was the most important settlement in the Negev region and its only proper city. Identified in 1838 by E. Robinson, it was subsequently visited by numerous researchers. The most important investigations took place in the form of surveys and excavations from the 1970s until 2001, during which, among other things, the only theatre in the region and the city’s cathedral were uncovered. However, despite several research projects, very basic information on the city and its genesis, history and structure has been lacking until now. Since 2015, this has been the focus of an international cooperation project that is investigating these fundamental questions using a multi-method approach. The focus here is also on the role of the city in the region, as it appears as an economic, administrative, cultural and religious centre. Particular emphasis is placed on the city’s flourishing in light of its precarious natural location within the Negev Desert. The article reflects the combined findings of remote sensing, archaeological survey, geophysical prospection, targeted excavations, geochemical soil sampling and extensive find material analyses and thus provides an unprecedented insight into the character and development of ancient Elusa

Metabolic Silencing via Methionine-Based Amino Acid Restriction in Head and Neck Cancer

In recent years, various forms of caloric restriction (CR) and amino acid or protein restriction (AAR or PR) have shown not only success in preventing age-associated diseases, such as type II diabetes and cardiovascular diseases, but also potential for cancer therapy. These strategies not only reprogram metabolism to low-energy metabolism (LEM), which is disadvantageous for neoplastic cells, but also significantly inhibit proliferation. Head and neck squamous cell carcinoma (HNSCC) is one of the most common tumour types, with over 600,000 new cases diagnosed annually worldwide. With a 5-year survival rate of approximately 55%, the poor prognosis has not improved despite extensive research and new adjuvant therapies. Therefore, for the first time, we analysed the potential of methionine restriction (MetR) in selected HNSCC cell lines. We investigated the influence of MetR on cell proliferation and vitality, the compensation for MetR by homocysteine, the gene regulation of different amino acid transporters, and the influence of cisplatin on cell proliferation in different HNSCC cell lines