Introduction: The Fogarty International Research Ethics Education and Curriculum Development Program in Historical Context

In response to the increasing need for research ethics expertise in low and middle income countries (LMICs), the NIH's Fogarty International Research Ethics Education and Curriculum Development Program has provided grants for the development of training programs in international research ethics for LMIC professionals since 2000. This collection of papers draws upon the combined expertise of Fogarty grantees, trainees, and other experts to assess the state of research ethics in LMICs, and the lessons learned over 12 years of international research ethics education; to assess future needs; and to chart a way forward to meet those needs. In this introductory paper we briefly sketch the evolution of research ethics as applied to LMIC research, the underpinning and evolution of the Fogarty bioethics program, and summarize key conclusions from the other papers in the collection

The proficient I.T. consultant: A study of the professional

Information Technology Consulting is an exciting and faced paced field where teams of professionals combine their expertise to help businesses reach their goals by improving their information systems. An information system is a combination of hardware, software, infrastructure and trained personnel organized to facilitate planning, control, coordination, and decision making in an organization. Consultants in this field employ a composite skillset consisting of business and technology proficiency in order to solve complex business problems. Many students are interested in entering the I.T. consulting field but do not know where to begin or what they need to focus on in order to succeed. Students find themselves asking: “What do I need to be able to do?” This question is a difficult one as the answer typically has not been a simple or concise one. While there is no definitive “list” of these skills, the goal of this thesis is to provide a transferable, general skillset that is required in order to distinguish oneself as an excellent I.T. consultant. This research will focus mainly on the breadth of the subject while highlighting a few key areas of depth

Study of the effect of clay particles on low salinity water injection in sandstone reservoirs

The need for optimal recovery of crude oil from sandstone and carbonate reservoirs around the world has never been greater for the petroleum industry. Water-flooding has been applied to the supplement primary depletion process or as a separate secondary recovery method. Low salinity water injection is a relatively new method that involves injecting low salinity brines at high pressure similar to conventional water-flooding techniques, in order to recover crude oil. The effectiveness of low salinity water injection in sandstone reservoirs depends on a number of parameters such as reservoir temperature, pressure, type of clay particle and salinity of injected brine. Clay particles present on reservoir rock surfaces adsorb polar components of oil and modify wettability of sandstone rocks to the oil-wet state, which is accountable for the reduced recovery rates by conventional water-flooding. The extent of wettability alteration caused by three low salinity brines on oil-wet sandstone samples containing varying clay content (15% or 30%) and type of clay (kaolinite/montmorillonite) were analyzed in the laboratory experiment. Contact angles of mica powder and clay mixture (kaolinite/montmorillonite) modified with crude oil were measured before and after injection with three low salinity sodium chloride brines. The effect of temperature was also analyzed for each sample. The results of the experiment indicate that samples with kaolinite clay tend to produce higher contact angles than samples with montmorillonite clay when modified with crude oil. The highest degree or extent of wettability alteration from oil-wet to intermediate-wet state upon injection with low salinity brines was observed for samples injected with brine having salinity concentration of 2000 ppm. The increase in temperature tends to produce contact angles values lying in the higher end of the intermediate-wet range (75°–115°) for samples treated at 50 °C, while their corresponding samples treated at 25 °C produced contact angle values lying in the lower end of intermediate-wet range

Open Source Software for Automatic Detection of Cone Photoreceptors in Adaptive Optics Ophthalmoscopy Using Convolutional Neural Networks

Imaging with an adaptive optics scanning light ophthalmoscope (AOSLO) enables direct visualization of the cone photoreceptor mosaic in the living human retina. Quantitative analysis of AOSLO images typically requires manual grading, which is time consuming, and subjective; thus, automated algorithms are highly desirable. Previously developed automated methods are often reliant on ad hoc rules that may not be transferable between different imaging modalities or retinal locations. In this work, we present a convolutional neural network (CNN) based method for cone detection that learns features of interest directly from training data. This cone-identifying algorithm was trained and validated on separate data sets of confocal and split detector AOSLO images with results showing performance that closely mimics the gold standard manual process. Further, without any need for algorithmic modifications for a specific AOSLO imaging system, our fully-automated multi-modality CNN-based cone detection method resulted in comparable results to previous automatic cone segmentation methods which utilized ad hoc rules for different applications. We have made free open-source software for the proposed method and the corresponding training and testing datasets available online

Automatic Detection of Cone Photoreceptors In Split Detector Adaptive Optics Scanning Light Ophthalmoscope Images

Quantitative analysis of the cone photoreceptor mosaic in the living retina is potentially useful for early diagnosis and prognosis of many ocular diseases. Non-confocal split detector based adaptive optics scanning light ophthalmoscope (AOSLO) imaging reveals the cone photoreceptor inner segment mosaics often not visualized on confocal AOSLO imaging. Despite recent advances in automated cone segmentation algorithms for confocal AOSLO imagery, quantitative analysis of split detector AOSLO images is currently a time-consuming manual process. In this paper, we present the fully automatic adaptive filtering and local detection (AFLD) method for detecting cones in split detector AOSLO images. We validated our algorithm on 80 images from 10 subjects, showing an overall mean Dice’s coefficient of 0.95 (standard deviation 0.03), when comparing our AFLD algorithm to an expert grader. This is comparable to the inter-observer Dice’s coefficient of 0.94 (standard deviation 0.04). To the best of our knowledge, this is the first validated, fully-automated segmentation method which has been applied to split detector AOSLO images

Effects of Clutter on Egocentric Distance Perception in Virtual Reality

To assess the impact of clutter on egocentric distance perception, we performed a mixed-design study with 60 participants in four different virtual environments (VEs) with three levels of clutter. Additionally, we compared the indoor/outdoor VE characteristics and the HMD's FOV. The participants wore a backpack computer and a wide FOV head-mounted display (HMD) as they blind-walked towards three distinct targets at distances of 3m, 4.5m, and 6m. The HMD's field of view (FOV) was programmatically limited to 165{\deg}$\times$110{\deg}, 110{\deg}$\times$110{\deg}, or 45{\deg}$\times$35{\deg}. The results showed that increased clutter in the environment led to more precise distance judgment and less underestimation, independent of the FOV. In comparison to outdoor VEs, indoor VEs showed more accurate distance judgment. Additionally, participants made more accurate judgements while looking at the VEs through wider FOVs.Comment: This paper was not published yet in any venue or conference/journal, ACM conference format was used for the paper, authors were listed in order from first to last (advisor), 10 pages, 10 figure

Constructing Diabatic States from Adiabatic States: Extending Generalized Mulliken–Hush to Multiple Charge Centers with Boys Localization

This article shows that, although Boys localization is usually applied to single-electron orbitals, the Boys method itself can be applied to many electron molecular states. For the two-state charge-transfer problem, we show analytically that Boys localization yields the same charge-localized diabatic states as those found by generalized Mulliken–Hush theory. We suggest that for future work in electron transfer, where systems have more than two charge centers, one may benefit by using a variant of Boys localization to construct diabatic potential energy surfaces and extract electronic coupling matrix elements. We discuss two chemical examples of Boys localization and propose a generalization of the Boys algorithm for creating diabatic states with localized spin density that should be useful for Dexter triplet-triplet energy transfer

Determinants of consumers’ choice behaviour for fresh fish types

The demand for and supply of fresh fish in many developing countries in the world today Nigeria inclusive, are yet to satisfy the annual dietary needs of their citizenry. This phenomenon, therefore, put unresisting pressure on the need to identify and grow more fresh fish that can meet the socio-cultural and economic desires of consumers. In the light of this, the present study examines the determinants of consumers’ choice behaviour for fresh fish types in Nigeria. Primary data were collected from 360 household heads through a structured questionnaire using a multistage sampling procedure. Multinomial logit regression model (MNL) was employed to analyse the impacts of socio-economic and fish-specific attributes of consumer choice for fresh fish. Results showed that 81 per cent were female households with a mean age of 35 years and mean household size of 4 members. Mean years of schooling and monthly expenditure were 13 and ₦3,611.94 (USD10.01), respectively. Mean consumptions of fresh fish category were mudfish (0.3354), catfish (0.1889), tilapia (0.2167), trunk fish (0.1138) and snakehead fish (0.1444). The McFadden R2 was 0.50 and the validity of independence of irrelevant alternatives hypothesis for the use of MNL was not violated given a p-value of 0.7618. Results showed that consumers' income, price of the fish, level of education, household size, experience and freshness had a significant impact on fresh fish choices. The study therefore recommends that policy that will increase consumers’ satisfaction for every naira spent on fresh fish and improve fish qualities should be given proper attentions

The radio emission in radio-quiet quasars: the VLBA perspective

The origin of the radio emission in radio-quiet quasars (RQQ) is not established yet. We present new VLBA observations at 1.6 and 4.9 GHz of ten RQQ (nine detected), which together with published earlier observations of eight RQQ (five detected), forms a representative sample of 18 RQQ drawn from the Palomar-Green sample of low z (< 0.5) AGN. The spectral slope of the integrated emission extends from very steep (alpha < -1.98) to strongly inverted (alpha = +2.18), and the slopes of nine of the 14 objects are flat (alpha > -0.5). Most objects have an unresolved flat-spectrum core, which coincides with the optical Gaia position. The extended emission is generally steep-spectrum, has a low brightness temperature (< 10^7 K), and is displaced from the optical core (the Gaia position) by ~ 5-100 pc. The VLBA core flux is tightly correlated with the X-ray flux, and follows a radio to X-ray luminosity relation of log L_R/L_X = -6, for all objects with a black hole mass log M_BH/M_Sun < 8.5. The flatness of the core emission implies a compact source size (< 0.1 pc), which likely originates from the accretion disk corona. The mas-scale extended emission is optically thin and of clumpy structure, and is likely produced by an outflow from the center. Radio observations at higher frequencies can further test the accretion disk coronal emission interpretation for the core emission in RQQ.Comment: Accepted for publication in MNRA