1,518 research outputs found
An extension of Wiener integration with the use of operator theory
With the use of tensor product of Hilbert space, and a diagonalization
procedure from operator theory, we derive an approximation formula for a
general class of stochastic integrals. Further we establish a generalized
Fourier expansion for these stochastic integrals. In our extension, we
circumvent some of the limitations of the more widely used stochastic integral
due to Wiener and Ito, i.e., stochastic integration with respect to Brownian
motion. Finally we discuss the connection between the two approaches, as well
as a priori estimates and applications.Comment: 13 page
Risk of new onset diabetes mellitus in patients with asthma or COPD taking inhaled corticosteroids
SummaryBackgroundA recent case-controlled study reported an increased risk of diabetes mellitus in patients treated with inhaled corticosteroids for asthma or COPD, versus age-matched controls.ObjectiveThe purpose of the current study was to evaluate whether there was an increased risk of new onset diabetes mellitus or hyperglycaemia among patients with asthma or COPD treated with inhaled corticosteroids.MethodsA retrospective analysis evaluated all double-blind, placebo-controlled, trials in patients ≥4 years of age involving budesonide or budesonide/formoterol in asthma (26 trials; budesonide: n = 9067; placebo: n = 5926), and in COPD (8 trials; budesonide: n = 4616; non-ICS: n = 3643). A secondary dataset evaluated all double-blind, controlled trials in asthma involving the use of inhaled corticosteroids (60 trials; budesonide: n = 33,496; fluticasone: n = 2773).ResultsIn the primary asthma dataset, the occurrence of diabetes mellitus/hyperglycaemia adverse events (AEs) was 0.13% for budesonide and 0.13% for placebo (HR 0.98 [95% CI: 0.38–2.50], p = 0.96) and serious adverse events (SAEs) was 0% for budesonide and 0.05% for placebo. In the secondary dataset, the occurrence of diabetes/hyperglycaemia as AE and SAE was 0.19% and 0.03%, respectively. In the COPD dataset, the occurrence of diabetes mellitus/hyperglycaemia AEs was 1.3% for budesonide and 1.2% for non-ICS (HR 0.99 [95% CI: 0.67–1.46], p = 0.96) and SAEs was 0.1% for budesonide and 0.03% for non-ICS.Conclusion and clinical relevanceTreatment with inhaled corticosteroids in patients with asthma or COPD was not associated with increased risk of new onset diabetes mellitus or hyperglycaemia
Latency Locus Complements MicroRNA 155 Deficiency In Vivo
MicroRNA-155 (miR-155) is expressed in many cancers. It also executes evolutionary conserved functions in normal B cell development. We show that the Kaposi's sarcoma-associated herpesvirus (KSHV) latency locus, which contains an ortholog of miR-155, miR-K12-11, complements B cell deficiencies in miR-155 knockout mice. Germinal center (GC) formation was rescued in spleen, lymph node, and Peyer's patches. Immunoglobulin levels were restored. This demonstrates that KSHV can complement the normal, physiological function of miR-155
Holographic Superconductor for a Lifshitz fixed point
We consider the gravity dual of strongly coupled system at a Lifshitz-fixed
point and finite temperature, which was constructed in a recent work
arXiv:0909.0263. We construct an Abelian Higgs model in that background and
calculate condensation and conductivity using holographic techniques. We find
that condensation happens and DC conductivity blows up when temperature turns
below a critical value.Comment: 14 pages, 4 figures, v4: improved version, references adde
Performance assessment of promoter predictions on ENCODE regions in the EGASP experiment
BACKGROUND: This study analyzes the predictions of a number of promoter predictors on the ENCODE regions of the human genome as part of the ENCODE Genome Annotation Assessment Project (EGASP). The systems analyzed operate on various principles and we assessed the effectiveness of different conceptual strategies used to correlate produced promoter predictions with the manually annotated 5' gene ends. RESULTS: The predictions were assessed relative to the manual HAVANA annotation of the 5' gene ends. These 5' gene ends were used as the estimated reference transcription start sites. With the maximum allowed distance for predictions of 1,000 nucleotides from the reference transcription start sites, the sensitivity of predictors was in the range 32% to 56%, while the positive predictive value was in the range 79% to 93%. The average distance mismatch of predictions from the reference transcription start sites was in the range 259 to 305 nucleotides. At the same time, using transcription start site estimates from DBTSS and H-Invitational databases as promoter predictions, we obtained a sensitivity of 58%, a positive predictive value of 92%, and an average distance from the annotated transcription start sites of 117 nucleotides. In this experiment, the best performing promoter predictors were those that combined promoter prediction with gene prediction. The main reason for this is the reduced promoter search space that resulted in smaller numbers of false positive predictions. CONCLUSION: The main finding, now supported by comprehensive data, is that the accuracy of human promoter predictors for high-throughput annotation purposes can be significantly improved if promoter prediction is combined with gene prediction. Based on the lessons learned in this experiment, we propose a framework for the preparation of the next similar promoter prediction assessment
Opipramol
In the title compound (systematic name: 2-{4-[3-(5H-dibenz[b,f]azepin-5-yl)propyl]piperazin-1-yl}ethanol), C23H29N3O, the 5H-dibenz[b,f]azepine and piperazine rings adopt boat and chair conformations, respectively, and the overall shape of the fused ring part of the molecule is a butterfly. In the crystal, O—H⋯N and C—H⋯O hydrogen bonds link the molecules into a layer parallel to the bc plane
On effective superpotentials and Kutasov duality
We derive the effective superpotential for an N=1 SU(N_c) gauge theory with
one massless adjoint field and N_f massless fundamental flavors and cubic
tree-level superpotential for the adjoint field. This is a generalization of
the Affleck-Dine-Seiberg superpotential to gauge theories with one massless
adjoint matter field. Using Kutasov's generalization of Seiberg duality, we
then find the effective superpotential for a related theory with massive
fundamental flavors.Comment: 21 pages, Late
Energy Loss of Gluons, Baryons and k-Quarks in an N=4 SYM Plasma
We consider different types of external color sources that move through a
strongly-coupled thermal N=4 super-Yang-Mills plasma, and calculate, via the
AdS/CFT correspondence, the dissipative force (or equivalently, the rate of
energy loss) they experience. A bound state of k quarks in the totally
antisymmetric representation is found to feel a force with a nontrivial
k-dependence. Our result for k=1 (or k=N-1) agrees at large N with the one
obtained recently by Herzog et al. and Gubser, but contains in addition an
infinite series of 1/N corrections. The baryon (k=N) is seen to experience no
drag. Finally, a heavy gluon is found to be subject to a force which at large N
is twice as large as the one experienced by a heavy quark, in accordance with
gauge theory expectations.Comment: Latex 2e, 24 pages, 1 eps figure; v2: slightly amplified discussion
on the relation between the drag force and the tension of a spatial Wilson
loop; v3: minor changes, version to appear in JHE
Weak Mixing Angle and Higgs Mass in Gauge-Higgs Unification Models with Brane Kinetic Terms
We show that the idea of Gauge-Higgs unification(GHU) can be rescued from the
constraint of weak mixing angle by introducing localized brane kinetic terms in
higher dimensional GHU models with bulk and simple gauge groups. We find that
those terms lead to a ratio between Higgs and W boson masses, which is a little
bit deviated from the one derived in the standard model. From numerical
analysis, we find that the current lower bound on the Higgs mass tends to
prefer to exceptional groups E(6), E(7), E(8) rather than other groups like
SU(3l), SO(2n+1), G(2), and F(4) in 6-dimensional(D) GHU models irrespective of
the compactification scales. For the compactification scale below 1 TeV, the
Higgs masses in 6D GHU models with SU(3l), SO(2n+1), G(2), and F(4) groups are
predicted to be less than the current lower bound unless a model parameter
responsible for re-scaling SU(2) gauge coupling is taken to be unnaturally
large enough. To see how the situation is changed in more higher dimensional
GHU model, we take 7D S^{3}/ Z_{2} and 8D T^{4}/ Z_{2} models. It turns out
from our numerical analysis that these higher dimensional GHU models with gauge
groups except for E(6) can lead to the Higgs boson whose masses are predicted
to be above the current lower bound only for the compatification scale above 1
TeV without taking unnaturally large value of the model parameter, whereas the
Higgs masses in the GHU models with E(6) are compatible with the current lower
bound even for the compatification scale below 1 TeV.Comment: 22 pages, 4 figure
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