Sue Pattinson, Maggie Robson, Ann Beynon, the Handbook of Counseling Children and Young People, British Association for Counseling & Psychotherapy (Sage Publication: 2015, ISBN: 9781446252994)

The field of counseling children and young people is rapidly developing in recent years, the delivery of counsel, various approaches to counseling and the nature of counseling interventions is increasing in number and range and being applied across an increasing variety of contexts. The book, Counseling Children and Young People, brings evidences to readers of how therapeutic work with children, young people and related services has developed historically. The book is set on specific values and principles, the rights of the children, the need to keep the child as the centre of the therapeutic work and serves as a comprehensive guide to the field of counseling. DOI: 10.5281/zenodo.340608

Deployment Issues And Security Concerns With Wireless Local Area Networks: The Deployment Experience At A University

This paper presents and discusses various issues pertaining to the deployment of Wireless Local Area Networks (WLANs).  The popularity of WLANs has steadily increased in the last two years and has led to their deployment in a variety of organizations.  Yet, making a business case for WLANs is an important step in their deployment.  In addition to highlighting the need for a business case for WLAN deployment, the paper outlines the reasons for, benefits of, and security problems associated with, their deployment.  The latter part of this paper presents a case study about the deployment of a WLAN at the University of Akron.  Therein, it discusses the context for the deployment, the process that was used to justify the deployment, and the efforts made to protect users’ information from security deficiencies of wireless networks

Emerging role of egfr mutations in creating an immune suppressive tumour microenvironment

Several types of tumours overexpress the Epidermal Growth Factor Receptor (EGFR) in either wild type or mutated form. These tumours are often highly aggressive and difficult to treat. The underlying mechanisms for this phenomenon have remained largely unresolved, but recent publications suggest two independent mechanisms that may contribute. According to one line of research, tumours that overexpress the EGFR grow autonomously and become “addicted” to growth factor signalling. Inhibition of this signal using EGFR inhibitors can, therefore, induce cell death in tumour cells and lead to tumour shrinkage. The other line of research, as highlighted by recent findings, suggests that the overexpression, specifically of mutant forms of the EGFR, may create an immune-suppressive and lymphocyte depleted microenvironment within tumours. Such a lymphocyte depleted microenvironment may explain the resistance of EGFR overexpressing cancers to tumour therapies, particularly to check-point inhibitor treatments. In this article, we discuss the recent data which support an immune modulatory effect of EGFR signalling and compare these published studies with the most recent data from The Cancer Genome Atlas (TCGA), in this way, dissecting possible underlying mechanisms. We thereby focus our study on how EGFR overexpression may lead to the local activation of TGFβ, and hence to an immune suppressive environment. Consequently, we define a novel concept of how the mitogenic and immune modulatory effects of EGFR overexpression may contribute to tumour resistance to immunotherapy, and how EGFR specific inhibitors could be used best to enhance the efficacy of tumour therapy

Off-Shoring And Outsourcing

Because of a dramatic decrease in transportation and telecommunication costs, the digital revolution, and the forces of globalization, off-shoring has accelerated in the past few years.  While there is little doubt that off-shoring has brought hardship to thousands of workers and communities, there is also little doubt that it has benefited many worker and communities.  Today, off-shoring continues to generate considerable debate on the long-run impact. Also, there is considerable misunderstanding about this phenomenon.  In this paper, the authors make a distinction among the terms outsourcing, offshore outsourcing, and off-shoring.  Off-shoring has been facilitated by a deconstruction of the value chain, allowing firms to evaluate all activities as potential candidates for being performed outside the firm.  Reasons for the acceleration of off-shoring are outlined.  An explanation of why off-shoring is not a villain for the developed economies is also provided

Cosmological singularities in non-canonical models of dark energy

The pursuit of unraveling the true essence of dark energy has become an immensely captivating endeavor in modern cosmology. Alongside the conventional cosmological constant approach, a diverse range of ideas has been proposed, encompassing scalar field-based models and various modified gravity approaches. A particularly intriguing notion involves exploring scalar field dark energy models within quantum gravitationally motivated cosmologies, with non-canonical theories standing out as a prominent candidate in this context. Hence, in this work, we investigate three widely recognized non-canonical scalar field dark energy models: phantom, quintom, and DBI dark energy models. By employing the Goriely-Hyde procedure, we demonstrate the presence of singularities in both finite and infinite time within these frameworks. and that these singularities can manifest regardless of the system's initial conditions. Moreover, we further establish how cosmological singularities of types I-IV can arise in all of these models. The work goes to show that non-canonical regimes for dark energy can allow for most of the prominent cosmological singularities for a variety of models.Comment: v2, matches the accepted version in PDU, 28 pages with no figure

Quantifying the Environmental Determinants of Plant Demography

The environment dictates population growth rates (lambda). Rapid global change makes quantifying the roles of environmental stressors on populations a priority. We can scale from environmental effects on individuals to the consequences for lambda by using structured population models. However, collecting the data population modelling is resource intensive. I illustrate how data-driven approaches and experiments can be used to understand the consequences of environmental variation for individual performance and lambda, reducing fieldwork demands. First, I show that crowding effects and habitat quality can be approximated through model-selection and spatial autocorrelations of vital rates respectively. My crowding analysis shows that good habitat quality can mask strong intraspecific competition for the critically endangered carnivorous plant, Drosophyllum lusitanicum. I study the negative responses of British Drosera rotundifolia populations to experimental nitrogen addition. This peatland indicator species varied in responses to treatments and vital rates across sites, highlighting the need to spatially replicate demographic studies. I go on to apply retrospective decompositions to a range of ecological systems, comparing the functional decomposition approach with more common decomposition analyses of life table response experiments. I demonstrate that the functional decomposition approach is a simple, precise way to quantify the contribution of environmental variation and treatments on observed differences in lambda. I build site-specific integral projection models of D. rotundifolia and show that treatment-induced changes in vital rates can have strong interactive effects on lambda. Moreover, treatments that affect single vital rates can have non-additive effects. I use functional decompositions to understand multiple treatment effects on vital rates as an aggregate contribution to a change in lambda. I explain how retrospective decompositions have a useful role in informing population management strategies. This thesis illustrates how we can quantify and disentangle various environmental determinants of vital rates and their contributions to lambda across a range of ecosystems

Conservative management of traumatic brachial plexus injury: a case report

Brachial plexus injury (BPI) is one of the devastating conditions for patients, which has a negative impact on patients' quality of life. It renders patients with an inability to achieve functional independence. With advancements in surgeries and rehabilitation, improvement in these domains is possible. This case report describes the rehabilitation of a 28-year-old male patient. Being a driver by occupation and the only earning member in the family, upper limb function was essential for functional independence and resume work. After examination, problems were identified, goals were set, and intervention was planned. The patient took 2 months of inpatient rehabilitation six days a week. After completion of treatment, the patient was independent in basic and instrumental activities of daily living. The study concludes that structured, evidence-based physiotherapy treatment is effective in achieving functional independence and reducing disability in patients with traumatic BPI

Nonpolar residues in the presumptive pore‐lining helix of mechanosensitive channel MSL10 influence channel behavior and establish a nonconducting function

Mechanosensitive (MS) ion channels provide a universal mechanism for sensing and responding to increased membrane tension. MscS‐like (MSL) 10 is a relatively well‐studied MS ion channel from Arabidopsis thaliana that is implicated in cell death signaling. The relationship between the amino acid sequence of MSL10 and its conductance, gating tension, and opening and closing kinetics remains unstudied. Here, we identify several nonpolar residues in the presumptive pore‐lining transmembrane helix of MSL10 (TM6) that contribute to these basic channel properties. F553 and I554 are essential for wild type channel conductance and the stability of the open state. G556, a glycine residue located at a predicted kink in TM6, is essential for channel conductance. The increased tension sensitivity of MSL10 compared to close homolog MSL8 may be attributed to F563, but other channel characteristics appear to be dictated by more global differences in structure. Finally, MSL10 F553V and MSL10 G556V provided the necessary tools to establish that MSL10\u27s ability to trigger cell death is independent of its ion channel function