Dopamine- and tyramine-based derivatives of triazenes. Activation by tyrosinase and implications for prodrug design

We report the synthesis of triazene derivatives, and their evaluation as substrates for tyrosinase. The conversion of prodrugs to the ortho-quinone was confirmed by LC-MS

Supercritical fluid impregnation of a biocompatible polymer for ophthalmic drug delivery

Supercritical fluid impregnation was tested to prepare a new ophthalmic drug delivery device. Poly(methylmethacrylate-co-ethylhexylacrylate-co-ethyleneglycoldimethacrylate), P(MMA-EHA-EGDMA) has been proposed by Mariz [M. Mariz, Preparação de uma lente intra-ocular dotada de um sistema de libertação controlada de fármaco, Master Thesis, Universidade de Coimbra, 1999] as a promising matrix to be used for intraocular delivery of anti-inflammatory drugs used in eye surgery. This matrix was successfully impregnated with flurbiprofen, a non-steroidal anti-inflammatory agent.http://www.sciencedirect.com/science/article/B6VMF-4N02J5M-1/1/ee8d7c5effb50ccf2b99656a67b77da