187 research outputs found
Activité glutamate deshydrogénase Nadp+ d'une fraction antigénique immunogénique de Trypanosoma cruzi
Identification of cytoplasmic soluble antigens related to the major surface antigens of Leishmania braziliensis braziliensis and L. donovani chagasi
Circulation and behaviour of two major clones of Trypanosoma cruzi in Bolivian cycles
On the basis of isoenzyme studies and population genetic interpretation, we have previously designed a molecular identification tool of two major clones of #Trypanosoma cruzi based on both kDNA PCR amplification and southern hybridization using clone specific probes. These tools allow the direct identification of two genetic sub-groups of clones, genetically unrelated in biological samples. In the main vector of Chagas' disease in Bolivia (#Triatoma infestans) we show that these two groups of clones are wide spread over large geographic distances and infect 92% of triatomes. We also observe high rates of mixed infections, ranging from 7.7% to 85.7% according to the localities. In a high endemic area, we show a significant difference of clone distribution between vectors and chagasic children. We have some arguments to think that both groups of clones are not selected during the transmission to man but that later, the control of parasitemia would be more effective over one of the two groups of clone. The second potential vector in Bolivia is #Triatoma sordida in some areas. Both groups of clones are occasionally found in this vector, but the large majority of clones are genetically unrelated to them. These data support, a sylvatic origin of both groups of clones further catch by #T. infestans domestic vector, the scarity of present contacts between both cycles sylvatic and domestic. (Résumé d'auteur
Données isoenzymatiques pour onze souches boliviennes de Trypanosoma cruzi : interprétation génétique et calcul de distances
Random by Amplified Polymorphic DNA Analysis of Sylvatic Trypanosoma cruzi Isolates Infers from French Guiana Accurate Phylogeny
Association between Trypanosoma cruzi zymodemes and specific humoral depression in chronic chagasic patients
Résultats préliminaires en faveur de l'existence d'un antigène majeur de surface, spécifique de LEISHMANIA BRAZILIENSIS BRAZILIENSIS
L'Etude comparative des antigènes de surface de 10 souches boliviennes de référence de la sous-espèce L. B. Braziliensis a permis de mettre en évidence une grande homogénéité au sein de ce groupe. Les souches éprouvées possèdent des profils antigéniques où domine un antigène de 72kD. (Résumé d'auteur
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