STS and social inequality:editors' Introduction

Editoria

Sunscreen sales, socio-economic factors, and melanoma incidence in Northern Europe:a population-based ecological study

In this ecological study, we drew upon recently published melanoma prevalence data, and compared them with historical market data and published socio-economic data to test for an association between historical sunscreen sales (1997-1999) and recent melanoma incidences (2008 and 2012) in 24 countries in Northern Europe. We also explored associations between current melanoma incidences and historical data on the following socio-demographic indicators: income, urbanization, and population aging. Melanoma incidences were higher in high-income countries where sales of sunscreen were also higher. Our results show that, at the population level, income was significantly associated with melanoma incidences, β = 0.0003, t(19) = 3.104, p < .006, and that increased sunscreen sales has not prevented higher income populations from being at higher risk of melanoma

Coaching to augment mentoring to achieve faculty diversity:a randomized controlled trial

Purpose: The Academy for Future Science Faculty (the Academy) is a novel coaching intervention for biomedical PhD students designed to address limitations in previous efforts to promote faculty diversity. Unlike traditional research mentoring, the Academy includes both group and individual coaching, coaches have no research or evaluation roles with the students, and it is based on social science theories. The authors present a qualitative case study of one of the coaching groups and provide statistical analyses indicating whether one year in the Academy effects students’ perceptions of the achievability and desirability of an academic career. Method: The authors tested (July 2012–July 2013), with Northwestern University ethical approval, the Academy via a longitudinal randomized controlled trial. Participants were 121 latter-stage biomedical PhD students. The authors collected data via questionnaires, interviews, and meeting recordings. Results: The case study shows how group career coaching can effectively supplement traditional one-to-one research mentoring; provide new role models for underrepresented minority students; and provide theory-based lenses through which to engage in open conversations about race, gender, and science careers. Repeated-measures analysis of variance showed that perceived achievability increased in the Academy group from baseline to one-year follow-up (mean, 5.75 versus 6.39) but decreased in the control group (6.58 versus 5.81). Perceived desirability decreased significantly less (P < .05) in the Academy group (7.00 versus 6.36) than in the control group (7.83 versus 5.97). Conclusions: Early results suggest that an academic career coaching model can effectively supplement traditional research mentoring and promote persistence toward academic careers

Sleep behaviour relates to language skills in children with and without communication disorders

BACKGROUND: Sleep problems are common in children with autism spectrum disorder (ASD). There is also emerging evidence that sleep quality influences language learning in typical development. However there is a gap within the literature in regards to sleep and developmental language disorder in children (DLD). OBJECTIVES: The aims of this study were to: i) compare sleep patterns of children with communication disorders to the sleep patterns of their typical peers, and ii) ascertain whether sleep patterns related to language in this sample. METHOD: The relationship between sleep and language was investigated via parental questionnaires. There were sixty-five child participants in total aged between 3-18 years. Parents reported on 28 children with a developmental communication disorder (CD; ASD n=8 or DLD n=20) and 37 who were typical developing. RESULTS: The children with a developmental communication disorder showed more sleep problems than their typical peers particularly in terms of getting to sleep and early waking. Furthermore, significant correlations were found between sleep behaviour and language for children in both groups. CONCLUSION: Children with CD may have poorer sleep patterns than their typical peers which could compound developmental language difficulties

Introducing the citizens’ POLIS: a new approach to online citizen participation in political decision-making

Recently, arguments for the extension of citizen participation into decision-making processes have become a vogue within political discourses. Governments in a number of countries, including the UK, have stated the need for new processes of inclusion to be explored practically. Such statements are rooted in social science theory, and it can be argued that social scientists should play a central role in experimenting with new methods of implementing citizen participation. At the same time, the rise of e-democracy has suggested new means and new media across which participation can occur. This paper discusses one such participation experiment – the Citizens’ POLIS (Participatory On-Line Interactive System). The Citizens’ POLIS is a multi-phase, multi-method, hypermedia participation process. This working paper seeks to introduce the general methodological assumptions and practical features of the Citizens’ POLIS, on which the author’s empirical research, currently in progress, is based

Crystallization, X-ray diffraction analysis and preliminary structure determination of the TIR domain from the flax resistance protein L6

The Toll/interleukin-1 receptor (TIR) domain is a protein-protein interaction domain that is found in both animal and plant immune receptors. In animal Toll-like receptor signalling, both homotypic TIR-domain interactions between two receptor molecules and heterotypic interactions between receptors and TIR-domain-containing adaptors are required for initiation of an innate immune response. The TIR domains in cytoplasmic nucleotide-binding/leucine-rich repeat (NB-LRR) plant disease-resistance proteins are not as well characterized, but recent studies have suggested a role in defence signalling. In this study, the crystallization, X-ray diffraction analysis and preliminary structure determination of the TIR domain from the flax resistance protein L6 (L6TIR) are reported. Plate-like crystals of L6TIR were obtained using PEG 200 as a precipitant and diffracted X-rays to 2.3 angstrom resolution. Pseudo-translation complicated the initial assignment of the crystal symmetry, which was ultimately found to correspond to space group P2(1)2(1)2 with two molecules per asymmetric unit. The structure of L6TIR was solved by molecular replacement using the structure of the TIR-domain-containing protein AT1G72930 from Arabidopsis as a template

Luminescent 1,8-Naphthalimide-Derived ReI Complexes: syntheses, spectroscopy, X-ray structure and preliminary bioimaging in fission yeast cells

A series of picolyl-functionalised, fluorescent 1,8-naphthalimide ligands (L) have been synthesised and coordi-nated to ReI to form luminescent cationic complexes of the general form fac-[Re(phen)(CO)3(L)]BF4. The complexes were characterised by using a range of spectroscopic and analytical techniques. One example of a complex was also characterised in the solid-state by using single-crystal X-ray diffraction, reveal-ing a distorted octahedral coordination sphere at ReI and Re– C/Re–N bond lengths within the expected ranges. All ligands were shown to be fluorescent, with the 4-amino derivatives showing intramolecular charge transfer in the visible region (511–534 nm). The complexes generally showed a mixture of ligand-centred and/or 3MLCT emission depending upon the na-ture of the coordinated 1,8-naphthalimide ligand. For selected complexes, confocal fluorescence microscopy was undertaken by using fission yeast cells (Schizosaccharomyces pombe) and showed that the structure of the 1,8-naphthalimide ligand influ-ences the uptake and localisation of the rhenium complex