Perception and Resistance Mechanism of some Metal-drug Complexes and Their Roles as Antibacterial

Metal-based drugs have undergone much development and application for therapeutic and diagnostic purposes for many decades since the huge success of cisplatin and other successful metal-drug complexes in the clinical stages. Furthermore, this metal-based drug has come up with a lot of signs of resistance and side-effects in their uses. This review points to some of the resistance natures and mechanisms of previously synthesized complexes in the field of chemistry

A Green Synthesized SnO2 Photo-Catalyst for Effective Degradation of Biomedical Industrial Waste

Using a green synthesis approach, we have synthesized SnO2 nanoparticles. The morphology of the nanoparticles are characterise by scanning electron microscopy. The UV-vis spectroscopy technique was used to study the optical characteristics. The different parameters such as dosage of catalyst, initial concentration of drugs, effect of pH and other parameters were estimated. The Visible light was irradiated over sample solution at different pH values, and the photo-catalytic effect of the SnO2 nano-particle was observed for degradation of ciprofloxacin drugs. The absorption spectra showed a stronger absorption peak at 273 nm representing the ciprofloxacin drugs. The photo-generated electron of nano-particles degradation drugs, which shows decrease absorption intensity. The results revealed that the photo-catalytic degradation process works well at pH 7. The higher degradation efficiency was observed by following the pseudo-first-order kinetics

Synthesis, characterization, crystal structure and antimicrobial studies of a novel Cu(II) complex based on itaconic acid and nicotinamide

A novel complex was synthesized from Cu(II), nicotinamide and itaconic acid and is formulated as [Cu(C5H4O4)2(C6H6N2O)2(H2O)2·2(H2O)] (1). The compound was characterized by elemental analysis, FTIR spectroscopy, UV-Vis and single crystal X-ray diffraction. The complex crystallizes in the triclinic P-1 space group, with a = 7.5111(2) Å, b = 9.8529(3) Å, c = 10.5118(4) Å, α = 116.244(3)°, β = 90.291(3)°, γ = 103.335(3)°, V = 673.81(4) Å3, Z = 1.The octahedral geometry around the copper(II) ion is of the form CuN2O4 consisting of two molecules of nicotinamide acting as monodentate ligand through the nitrogen atoms, two molecules itaconate ligand and two coordinated water molecules each coordinating through the oxygen atoms. The structure of 1 showed infinite chains build up linking the molecules together via strong OH⋯O and NH⋯O intermolecular hydrogen bonds generating a two dimensional network sheet along c axis. The antimicrobial study of the synthesized complex 1 was investigated and showed higher antibacterial activity against all the organisms comparing with Copper(II) nicotinamide 2 and Copper(II) itaconate 3.Peer Reviewe

Zinc(II) Complex of <i>Meso</i>-Tetraphenylporphyrin With 4-Methoxyaniline: Crystal Structure and Antimicrobial Activities of 4-Methoxyaniline-5, 10, 15, 20-Tetraphenyl-Porphyrinatozinc (II)

<div><p>4-Methoxyaniline-5,10,15,20-tetraphenylporphyrinatozinc(II), [(ZnTPP(MOAN)] <b>1</b> was synthesized (MOAN = 4-methoxyaniline) and characterized by elemental analysis and spectroscopic techniques. The molecular structure of <b>1</b> was determined by single-crystal X-ray crystallography. The structure revealed a triclinic crystal system and the space group <i>P</i>1 with the central metal adopting slightly distorted square pyramidal geometry with 4-methoxyaniline in the axial position. The antimicrobial activities were carried out using a well diffusion method and the zone of inhibition of four bacteria and two fungi was measured.</p></div

Synthesis, thermal properties and biological study of metal(II) nicotinamide complexes containing fumarate dianion and fumaric acid: crystal structure of [Ni(H 2 O) 4 (nia) 2 ](fum)·(H 2 fum)

New divalent transition metal nicotinamide (nia) complexes containing fumarate (fum) dianion and fumaric acid (H2fum), [M(H2O)4(nia)2](fum)·(H2fum) [M = Co (1), Cu (2) and Ni (3)] have been synthesized. The compounds were characterized by elemental analyses, IR, UV-vis, XRPD and TGA. Structural analysis of 3 using single crystal X-ray diffraction technique revealed that the Ni(II) ion is coordinated by four aqua and two nicotinamide ligands in an octahedral geometry. The structure of 3 is completed with fumarate (fum²⁻) dianion acting as counter-ion while fumaric acid (H2fum) is present as a molecule of solvation. The three complexes were investigated for biological activities