The Identification of Conductor-Distinguished Functions of Conducting

The purpose of the present study was to identify whether conductors distinguish functions of conducting similarly to functions implied in previous research. A sample of 84 conductors with a full range of experience levels (M = 9.8) and of a full range of large ensemble types and ensemble age levels rated how much they pay attention to 82 research-derived conducting considerations as they conduct. The subject-to-variable ratio was smaller than advisable for factor analysis, yet the representatively diverse sample provided reliable ratings (a = .95) and factor results that corroborate traditional music-related functions—Mechanical Precision Function and Expressive Function—and nontraditional musician-oriented functions—Motivational Function, Physical Technique Function, Psychosocial Function, and Unrestrained Tone Function. Functions were discovered to divide based on opposing aims to control precise mechanics, musician attention, and musician energy and range of motion versus to release expression, tension and control of tone and tempo, and control of musicians in favor of sharing control with musicians. The six functions bring new clarity to the trends of conducting research and establish a potential new standard for conducting. Future research is needed to evaluate construct validity and determine reliable and valid measures of these six conducting functions

Atrioventricular block: Natural history after permanent ventricular pacing

The preimplantation status, postimplantation morbidity and causes of late mortality were summarized for 246 patients who underwent pacing for atrioventricular (A-V) block at the University of Michigan for the 14 years from 1961 to 1974. The survival rate at 1, 5 and 10 years was 88, 61 and 49 percent, respectively. Risk of death was greatest among patients with antecedent ischemic or hypertensive heart disease or congestive heart failure in the period before pacemaker implantation, patients older than 74 years at initial implantation and those receiving a pacemaker before 1965. Forty-two percent of the 109 deaths were related to apparent progression of underlying cardiac disease. Pacing system malfunction was a contributing documented cause of only 3 deaths. Even with permanent pacemaker implantation, patients with A-V block have a higher age-specific mortality rate than the general U.S. population. Survival improved steadily over the period of study. This change is attributed to apparent improvements in treatment of cardiovascular disease including more effective treatment of congestive heart failure and valve replacement for selected patients as well as elimination of immediate postoperative mortality.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/22653/1/0000204.pd

The matallicities of star-forming galaxies at intermediate redshifts 0.47 < z < 0.92

Estimates of the [O/H] metallicity of the star-forming gas in a sample of 66 CFRS galaxies between 0.47 < z < 0.92 have been made based on the flux ratios of bright emission lines. Most galaxies (> 75%) have the [O/H] ~ 8.9 metallicities that are seen locally in galaxies of similar luminosities. However, a minority (< 25%) appear to have significantly lower metallicities [O/H] < 8.6 as indicated by high values of the Pagel R23 parameter. The high metallicities of the majority of the galaxies suggest that they do not fade to be low metallicity dwarf galaxies today. Only one of the 66 galaxies has an optical emission line spectrum similar to the few Lyman break galaxies recently observed at z ~ 3, emphasizing the differences with that population. The inferred emission line gas [O/H] metallicity broadly correlates with luminosity in both the rest B- and J-bands but with considerable scatter introduced. The metallicity does not appear to correlate well with galaxy size, H-beta strength or, with the very limited data available, the kinematics. The metallicity does correlate well with the continuum optical-infrared colors in a way that could be explained as a combination of effects, none of which should produce large variations in the M/L ratio. These results support a "down-sizing" picture of galaxy evolution rather than a "fading dwarf" picture in which the luminous active galaxies at high redshift are highly brightened dwarf galaxies. The overall change in metallicity of star-forming galaxies over the last half of the age of the Universe appears to have been modest, Delta[O/H] = 0.08 +/- 0.06. This is consistent with the age-metallicity relation in the Galactic disk and is broadly consistent with models for the chemical evolution of the Universe, especially those that consider different environments.Comment: 26 pages, accepted for publication in Astrophysical Journal (July 10 2003

Dosimetric implications of the potential radionuclidic impurities in 153Sm-DOTMP

https://openworks.mdanderson.org/articleip/1000/thumbnail.jp

Machine Learning Based Classification of Deep Brain Stimulation Outcomes in a Rat Model of Binge Eating Using Ventral Striatal Oscillations

Neuromodulation-based interventions continue to be evaluated across an array of appetitive disorders but broader implementation of these approaches remains limited due to variable treatment outcomes. We hypothesize that individual variation in treatment outcomes may be linked to differences in the networks underlying these disorders. Here, Sprague-Dawley rats received deep brain stimulation separately within each nucleus accumbens (NAc) sub-region (core and shell) using a within-animal crossover design in a rat model of binge eating. Significant reductions in binge size were observed with stimulation of either target but with significant variation in effectiveness across individuals. When features of local field potentials (LFPs) recorded from the NAc were used as predictors of the pre-defined stimulation outcomes (response or non-response) from each rat using a machine-learning approach (lasso), stimulation outcomes could be predicted with greater accuracy than expected by chance (effect sizes: core = 1.13, shell = 1.05). Further, these LFP features could be used to identify the best stimulation target for each animal (core vs. shell) with an effect size = 0.96. These data suggest that individual differences in underlying network activity may contribute to the variable outcomes of circuit based interventions and that measures of network activity have the potential to individually guide the selection of an optimal stimulation target and improve overall treatment response rates

The Impact of Tumour pH on Cancer Progression; Strategies for Clinical Intervention

Dysregulation of cellular pH is frequent in solid tumours and provides potential opportunities for therapeutic intervention. The acidic microenvironment within a tumour can promote migration, invasion and metastasis of cancer cells through a variety of mechanisms. Pathways associated with the control of intracellular pH that are under consideration for intervention include carbonic anhydrase IX, the monocarboxylate transporters (MCT, MCT1 and MCT4), the vacuolar-type H(+)-ATPase proton pump, and the sodium-hydrogen exchanger 1. This review will describe progress in the development of inhibitors to these targets

Peak Oxygen Uptake during and after Long-duration Space Flight

Aerobic capacity (VO2peak) previously has not been measured during or after long-duration spaceflight. PURPOSE: To measure VO2peak and submaximal exercise responses during and after International Space Station (ISS) missions. METHODS: Astronauts (9 M, 5 F: 49 +/- 5 yr, 175 +/- 7 cm, 77.2 +/- 15.1 kg, 40.6 +/- 6.4 mL/kg/min [mean +/-SD]) performed graded peak cycle tests ~90 days before spaceflight, 15 d (FD15) after launch and every ~30 d thereafter during flight, and 1 (R+1), 10 (R+10), and 30 d (R+30) after landing. Oxygen consumption (VO2) and heart rate (HR) were measured from rest to peak exercise, while cardiac output (Q), stroke volume (SV), and arterial-venous oxygen difference (a-vO2diff) were measured only during rest and submaximal exercise. Data were analyzed using mixed-model linear regression. Body mass contributed significantly to statistical models, and thus results are reported as modeled estimates for an average subject. RESULTS: Early inflight (FD15) VO2peak was 17% lower (95% CI = - 22%, -13%) than preflight. VO2peak increased during spaceflight (0.001 L/min/d, P = 0.02) but did not return to preflight levels. On R+1 VO2peak was 15% (95% CI = -19%, -10%) lower than preflight but recovered to within 2% of preflight by R+30 (95% CI = -6%, +3%). Peak HR was not significantly different from preflight at any time. Inflight submaximal VO2 and a-vO2diff were generally lower than preflight, but the Q vs. VO2 slope was unchanged. In contrast, the SV vs. VO2 slope was lower (P < 0.001), primarily due to elevated SV at rest, and the HR vs. VO2 slope was greater (P < 0.001), largely due to elevated HR during more intense exercise. On R+1 although the relationships between VO2 and Q, SV, and HR were not statistically different than preflight, resting and submaximal exercise SV was lower (P < 0.001), resting and submaximal exercise HR was higher (P < 0.002), and a-vO2diff was unchanged. HR and SV returned to preflight levels by R+30. CONCLUSION: In the average astronaut VO2peak was reduced during spaceflight and immediately after landing but factors contributing to lower VO2peak may be different during spaceflight and recovery. Maintaining Q while VO2 is reduced inflight may be suggestive of an elevated blood flow to vascular beds other than exercising muscles, but decreased SV after flight likely reduces Q at peak exertion

A cobalt complex of a microbial arene oxidation product

We report the first synthesis of a cobalt Cp diene complex wherein the diene is derived by microbial dearomatising dihydroxylation of an aromatic ring. The complex has been characterised crystallographically and its structure is compared to that of an uncomplexed diene precursor

Evaluation of pre-analytical factors affecting plasma DNA analysis.

Pre-analytical factors can significantly affect circulating cell-free DNA (cfDNA) analysis. However, there are few robust methods to rapidly assess sample quality and the impact of pre-analytical processing. To address this gap and to evaluate effects of DNA extraction methods and blood collection tubes on cfDNA yield and fragment size, we developed a multiplexed droplet digital PCR (ddPCR) assay with 5 short and 4 long amplicons targeting single copy genomic loci. Using this assay, we compared 7 cfDNA extraction kits and found cfDNA yield and fragment size vary significantly. We also compared 3 blood collection protocols using plasma samples from 23 healthy volunteers (EDTA tubes processed within 1 hour and Cell-free DNA Blood Collection Tubes processed within 24 and 72 hours) and found no significant differences in cfDNA yield, fragment size and background noise between these protocols. In 219 clinical samples, cfDNA fragments were shorter in plasma samples processed immediately after venipuncture compared to archived samples, suggesting contribution of background DNA by lysed peripheral blood cells. In summary, we have described a multiplexed ddPCR assay to assess quality of cfDNA samples prior to downstream molecular analyses and we have evaluated potential sources of pre-analytical variation in cfDNA studies

Small-scale stellar haloes: detecting low surface brightness features in the outskirts of Milky Way dwarf satellites

Dwarf galaxies are valuable laboratories for dynamical studies related to dark matter and galaxy evolution, yet it is currently unknown just how physically extended their stellar components are. Satellites orbiting the Galaxy's potential may undergo tidal stripping by the host, or alternatively, may themselves have accreted smaller systems whose debris populates the dwarf's own stellar halo. Evidence of these past interactions, if present, is best searched for in the outskirts of the satellite. However, foreground contamination dominates the signal at these large radial distances, making observation of stars in these regions difficult. In this work, we introduce an updated algorithm for application to Gaia data that identifies candidate member stars of dwarf galaxies, based on spatial, color-magnitude and proper motion information, and which allows for an outer component to the stellar distribution. Our method shows excellent consistency with spectroscopically confirmed members from the literature despite having no requirement for radial velocity information. We apply the algorithm to all $\sim$60 Milky Way dwarf galaxy satellites, and we find 9 dwarfs (Bo\"otes 1, Bo\"otes 3, Draco 2, Grus 2, Segue 1, Sculptor, Tucana 2, Tucana 3, and Ursa Minor) that exhibit evidence for a secondary, low-density outer profile. We identify many member stars which are located beyond 5 half-light radii (and in some cases, beyond 10). We argue these distant stars are likely tracers of dwarf stellar haloes or tidal streams, though ongoing spectroscopic follow-up will be required to determine the origin of these extended stellar populations.Comment: 24 pages, 13 figures, 4 tables, submitted to MNRA