561 research outputs found
Network strategies to understand the aging process and help age-related drug design
Recent studies have demonstrated that network approaches are highly
appropriate tools to understand the extreme complexity of the aging process.
The generality of the network concept helps to define and study the aging of
technological, social networks and ecosystems, which may give novel concepts to
cure age-related diseases. The current review focuses on the role of
protein-protein interaction networks (interactomes) in aging. Hubs and
inter-modular elements of both interactomes and signaling networks are key
regulators of the aging process. Aging induces an increase in the permeability
of several cellular compartments, such as the cell nucleus, introducing gross
changes in the representation of network structures. The large overlap between
aging genes and genes of age-related major diseases makes drugs which aid
healthy aging promising candidates for the prevention and treatment of
age-related diseases, such as cancer, atherosclerosis, diabetes and
neurodegenerative disorders. We also discuss a number of possible research
options to further explore the potential of the network concept in this
important field, and show that multi-target drugs (representing
"magic-buckshots" instead of the traditional "magic bullets") may become an
especially useful class of age-related future drugs.Comment: an invited paper to Genome Medicine with 8 pages, 2 figures, 1 table
and 46 reference
Centrality and transverse momentum dependence of elliptic flow of multi-strange hadrons and meson in Au+Au collisions at = 200 GeV
We present high precision measurements of elliptic flow near midrapidity
() for multi-strange hadrons and meson as a function of
centrality and transverse momentum in Au+Au collisions at center of mass energy
200 GeV. We observe that the transverse momentum dependence of
and is similar to that of and , respectively,
which may indicate that the heavier strange quark flows as strongly as the
lighter up and down quarks. This observation constitutes a clear piece of
evidence for the development of partonic collectivity in heavy-ion collisions
at the top RHIC energy. Number of constituent quark scaling is found to hold
within statistical uncertainty for both 0-30 and 30-80 collision
centrality. There is an indication of the breakdown of previously observed mass
ordering between and proton at low transverse momentum in the
0-30 centrality range, possibly indicating late hadronic interactions
affecting the proton .Comment: 7 pages and 4 figures, Accepted for publication in Physical Review
Letter
Measurement of the mass difference and the binding energy of the hypertriton and antihypertriton
According to the CPT theorem, which states that the combined operation of
charge conjugation, parity transformation and time reversal must be conserved,
particles and their antiparticles should have the same mass and lifetime but
opposite charge and magnetic moment. Here, we test CPT symmetry in a nucleus
containing a strange quark, more specifically in the hypertriton. This
hypernucleus is the lightest one yet discovered and consists of a proton, a
neutron, and a hyperon. With data recorded by the STAR
detector{\cite{TPC,HFT,TOF}} at the Relativistic Heavy Ion Collider, we measure
the hyperon binding energy for the hypertriton, and
find that it differs from the widely used value{\cite{B_1973}} and from
predictions{\cite{2019_weak, 1995_weak, 2002_weak, 2014_weak}}, where the
hypertriton is treated as a weakly bound system. Our results place stringent
constraints on the hyperon-nucleon interaction{\cite{Hammer2002,
STAR-antiH3L}}, and have implications for understanding neutron star interiors,
where strange matter may be present{\cite{Chatterjee2016}}. A precise
comparison of the masses of the hypertriton and the antihypertriton allows us
to test CPT symmetry in a nucleus with strangeness for the first time, and we
observe no deviation from the expected exact symmetry
Azimuthal anisotropy in U+U and Au+Au collisions at RHIC
Collisions between prolate uranium nuclei are used to study how particle
production and azimuthal anisotropies depend on initial geometry in heavy-ion
collisions. We report the two- and four-particle cumulants, and
, for charged hadrons from U+U collisions at =
193 GeV and Au+Au collisions at = 200 GeV. Nearly fully
overlapping collisions are selected based on the amount of energy deposited by
spectators in the STAR Zero Degree Calorimeters (ZDCs). Within this sample, the
observed dependence of on multiplicity demonstrates that ZDC
information combined with multiplicity can preferentially select different
overlap configurations in U+U collisions. An initial-state model with gluon
saturation describes the slope of as a function of multiplicity in
central collisions better than one based on Glauber with a two-component
multiplicity model.Comment: Final paper version accepted for publication in Phys. Rev. Lett. New
version includes comparisons to a constituent quark glauber mode
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