Modelling the effect of land use change on hydrological model parameters via linearized calibration method in the upstream of Huaihe River Basin, China

Conceptual rainfall–runoff models have become a basic tool for evaluating effects of land use/cover changes on the hydrologic processes in small-scale as well as large watersheds. The runoff-producing mechanism is influenced by land use/cover changes. In this study, we analysed the effect of land use change on hydrological model parameters by calibrating the model parameters of different time periods with different land use via a linearized calibration method. The parameter calibration of a conceptual model usually involves the construction of objective function and optimization methods for good performance of observed data. However, the objective function of the minimum-sum-squared error will introduce an unrelated optimum solution for the parameter calibration problem of a conceptual model, which belongs to a highly complex nonlinear system. Thus, a linearized parameter calibration method, which searches for the optimal value on a parameter surface, is presented, based on the analysis of the problems of the objective function of the minimum-sum-squared error. Firstly, an ideal model is shown that illustrates the efficiency and applicability of this method. Secondly, the novel method is demonstrated for solving the Xinanjiang daily model parameter calibration. Finally, 50 years of data are divided into 4 different periods for parameter comparison, through which the effects of land use/cover changes on runoff in Dapoling watershed are evaluated. The results show that the linearized parameter calibration method is convergent, reasonable and effective. For example, the model parameter of evapotranspiration coefficient KC varied considerably, from 0.658 to 0.922, in response to land use/cover change within the watershed.Keywords: land use/cover change; parameter calibration; linearized; upper Huaihe River Basi

Long-term latitudinal effects of precipitation change in global monsoon regions

Global paleomonsoon precipitation evolution is confined to asynchronous responses to global monsoons to shared forcings, including summer insolation, sea surface temperature, atmospheric circulation coupling, and ocean circulation. However, most studies are based on conclusions drawn from single or a few discrete records or deduced from top-down climate models, which limits our ability to understand the latitudinal effect of monsoon precipitation. In particular, precipitation is a locally constrained climate factor. Here, we present a comprehensive assessment of global monsoon precipitation over the last 12,000 cal year BP based on modern observations, paleoclimate simulations, paleoclimate records, and monsoon precipitation reconstructions over the past 12,000 cal year BP based on a bottom-up algorithm called climate field reconstruction approaches. The results show that the middle latitude monsoon precipitation is in line with the evolution of the insolation and significant long-term decreasing (increasing) trends in low latitude monsoon precipitation have not occurred over the last 12,000 years BP. For modern monsoon evolution, the monsoon precipitation also changes along the meridional direction, with overall decreasing precipitation in the global monsoon region and increasing precipitation in the monsoon margin area. Monsoon systems at different latitudes all record eight Holocene weak precipitation events, including the Younger Dryas (12,900 cal year BP to 11,700 cal year BP), which can be considered a strong effect caused by a significant reduction or collapse of a meridional ocean circulation system, namely, the Atlantic Meridional Overturning Circulation. Moreover, the low- and middle-latitude monsoon precipitation lags by approximately 2,000 years behind the onset of North Atlantic warming. Taken together, our findings provide important insights into the latitudinal effect of monsoon precipitation at different locations

Research progress of the impact of nonalcoholic fatty liver disease on chronic hepatitis B infection

Chronic hepatitis B (CHB) is an infectious disease caused by persistent infection with the hepatitis B virus (HBV) and is highly prevalent worldwide. Non-alcoholic fatty liver disease (NAFLD) is a group of liver diseases related to metabolic abnormalities, excluding those caused by alcohol consumption or other liver injury factors. In recent years, with improvement of living standards and changes in lifestyle, the incidence of NAFLD has been increasing substantially, becoming the most common type of liver diseases in China and Western countries, and the second leading cause of liver transplantation in the West. The rising prevalence of NAFLD has also led to an increase in the incidence of NAFLD in patients with chronic HBV infection. However, there is considerable controversy both domestically and internationally regarding the relationship between these two diseases, including the disease progression, pathogenesis, impact on antiviral treatment efficacy, and prognosis of these concomitant CHB and NAFLD patients. Currently, both domestic and international guidelines lack detailed descriptions of diagnostic and treatment strategies for these conditions. This article summarizes the recent research progress in concomitant CHB and NAFLD, including epidemiology, diagnostic criteria, the impact of NAFLD on the virology of HBV infection, potential mechanisms of NAFLD-induced negative regulation of HBV, the effect of NAFLD on antiviral therapy efficacy, and prognosis. This article aims to gain a deeper understanding of the diseases themselves and provide new insights for basic and clinical research as well as diagnostic and treatment approaches

Testing a Conceptual Lumped Model in Karst Area, Southwest China

Karst aquifers are known for their heterogeneous physical properties and irregular complex flow patterns which make it a challenge to describe the hydrological behavior and to quantitatively define the distribution of river flow components using hydrologic models. In this paper, a conceptual lumped hydrologic model, Xin’anjiang model (XAJ), was applied in Sancha River, which is a karst basin in southwest China, for the simulation of streamflow. The performance of XAJ model was evaluated based on the model’s ability to reproduce the streamflow and baseflow. Percentage of bias (PBIAS), Nash-Sutcliffe efficiency (NSE), coefficient of determination (R2), and standard deviation (RSR) were calculated between the simulated and measured flow for both calibration and validation period. The low PBIAS and RSR (2.7% and 0.367 for calibration period, 1.3% and 0.376 for validation period) and the high NSE and R2 (0.866 and 0.866 for calibration period, 0.858 and 0.860 for validation period) indicate that the model structure and parameters are of reasonable validity. Furthermore, streamflow was separated to baseflow and surface flow using the “baseflow programme,” and the calculated results indicate that the model could also reproduce the response of baseflow in such karst system

New insights into autophagy in inflammatory subtypes of asthma

Asthma is a heterogeneous airway disease characterized by airway inflammation and hyperresponsiveness. Autophagy is a self-degrading process that helps maintain cellular homeostasis. Dysregulation of autophagy is involved in the pathogenesis of many diseases. In the context of asthma, autophagy has been shown to be associated with inflammation, airway remodeling, and responsiveness to drug therapy. In-depth characterization of the role of autophagy in asthma can enhance the understanding of the pathogenesis, and provide a theoretical basis for the development of new biomarkers and targeted therapy for asthma. In this article, we focus on the relationship of autophagy and asthma, and discuss its implications for asthma pathogenesis and treatment

Evaluation of the green development efficiency of marine fish culture in China

Green development efficiency (GDE) is an important criterion for measuring the level of green development. GDE considers not only economic development efficiency but also environmental costs. In China, marine fish culture, as one of the pillar industries of mariculture, promotes green development and industrial transformation and upgradation. Based on data from the field surveys of marine fish farmers (2017–2019) and the China Fishery Statistical Yearbook (2018–2020), this study establishes an evaluation index system and uses the super-slack-based measure model (Super-SBM) to evaluate the GDE of marine fish culture. The results show that the average GDE of marine fish culture in China was 0.9529, which was in an inefficient state. As for culture species, golden pompano (Trachinotus ovatus) and cobia (Rachycentron canadum) were the two species farmed in an efficient state, with a GDE of 1.2107 and 1.0659, respectively. Regarding culture modes, green modes (offshore cage aquaculture, industrial recirculating aquaculture, and engineering pond aquaculture) were in an efficient state, with a GDE of 1.2310, 1.0827, and 1.0401, respectively. Traditional modes (industrial flow-through aquaculture, ordinary cage aquaculture, and ordinary pond aquaculture) were in an inefficient state, with their GDE being 0.9884, 0.8746, and 0.8248, respectively. Green modes have higher GDE than traditional modes. In contrast, the production and culture areas of green modes were less than those of traditional modes because the profits of the same species in green modes were lower than those in traditional modes. The results of this study present an objective assessment of the GDE of marine fish culture in China and provide valuable insights for analyzing the mechanisms to improve the GDE of marine fish culture

Human MCTS1-dependent translation of JAK2 is essential for IFN-γ immunity to mycobacteria.

Human inherited disorders of interferon-gamma (IFN-γ) immunity underlie severe mycobacterial diseases. We report X-linked recessive MCTS1 deficiency in men with mycobacterial disease from kindreds of different ancestries (from China, Finland, Iran, and Saudi Arabia). Complete deficiency of this translation re-initiation factor impairs the translation of a subset of proteins, including the kinase JAK2 in all cell types tested, including T lymphocytes and phagocytes. JAK2 expression is sufficiently low to impair cellular responses to interleukin-23 (IL-23) and partially IL-12, but not other JAK2-dependent cytokines. Defective responses to IL-23 preferentially impair the production of IFN-γ by innate-like adaptive mucosal-associated invariant T cells (MAIT) and γδ T lymphocytes upon mycobacterial challenge. Surprisingly, the lack of MCTS1-dependent translation re-initiation and ribosome recycling seems to be otherwise physiologically redundant in these patients. These findings suggest that X-linked recessive human MCTS1 deficiency underlies isolated mycobacterial disease by impairing JAK2 translation in innate-like adaptive T lymphocytes, thereby impairing the IL-23-dependent induction of IFN-γ