2,470 research outputs found
Asymptotic Level Density of the Elastic Net Self-Organizing Feature Map
Whileas the Kohonen Self Organizing Map shows an asymptotic level density
following a power law with a magnification exponent 2/3, it would be desired to
have an exponent 1 in order to provide optimal mapping in the sense of
information theory. In this paper, we study analytically and numerically the
magnification behaviour of the Elastic Net algorithm as a model for
self-organizing feature maps. In contrast to the Kohonen map the Elastic Net
shows no power law, but for onedimensional maps nevertheless the density
follows an universal magnification law, i.e. depends on the local stimulus
density only and is independent on position and decouples from the stimulus
density at other positions.Comment: 8 pages, 10 figures. Link to publisher under
http://link.springer.de/link/service/series/0558/bibs/2415/24150939.ht
Investigation of top mass measurements with the ATLAS detector at LHC
Several methods for the determination of the mass of the top quark with the
ATLAS detector at the LHC are presented. All dominant decay channels of the top
quark can be explored. The measurements are in most cases dominated by
systematic uncertainties. New methods have been developed to control those
related to the detector. The results indicate that a total error on the top
mass at the level of 1 GeV should be achievable.Comment: 47 pages, 40 figure
3D-4D Interlinkage Of qqq Wave Functions Under 3D Support For Pairwise Bethe-Salpeter Kernels
Using the method of Green's functions within a Bethe-Salpeter framework
characterized by a pairwise qq interaction with a Lorentz-covariant 3D support
to its kernel, the 4D BS wave function for a system of 3 identical relativistic
spinless quarks is reconstructed from the corresponding 3D form which satisfies
a fully connected 3D BSE. This result is a 3-body generalization of a similar
2-body result found earlier under identical conditions of a 3D support to the
corresponding qq-bar BS kernel under Covariant Instaneity (CIA for short). (The
generalization from spinless to fermion quarks is straightforward).
To set the CIA with 3D BS kernel support ansatz in the context of
contemporary approaches to the qqq baryon problem, a model scalar 4D qqq BSE
with pairwise contact interactions to simulate the NJL-Faddeev equations is
worked out fully, and a comparison of both vertex functions shows that the CIA
vertex reduces exactly to the NJL form in the limit of zero spatial range. This
consistency check on the CIA vertex function is part of a fuller accounting for
its mathematical structure whose physical motivation is traceable to the role
of `spectroscopy' as an integral part of the dynamics.Comment: 20 pages, Latex, submitted via the account of K.-C. Yan
Paracrine delivery of therapeutic biologics for cancer
A fundamental goal of cancer drug delivery is to achieve sufficient levels within the tumour without leading to high systemic concentrations that might cause off-target toxicities. In situ production of protein-based therapeutics by tumour cells provides an attractive alternative to treatment with repeated high bolus injections, as secretion by the tumour itself could provide high local
concentrations that act in a paracrine fashion over an extended duration. For this purpose, we have developed a non-oncolytic adenoviral delivery system that allows for targeting of Ad5 to discrete cell types by redirecting viral tropism to cell surface biomarkers through the use of interchangeable adapters. Furthermore, we recently described the engineering of a protein-based ‘shield’ that is coated on the Ad5 capsid, which, together
with the retargeting adapters, allows for improved tumour specificity
and prevention of viral clearance. To test this delivery
strategy in vivo, SCID-beige mice bearing orthotopic BT474
xenografts were treated with three doses of either a cancerspecific,
non-replicative Ad5 that encodes a secreted anti-HER2
antibody, trastuzumab, in its genome, or with the protein therapeutic
itself (Herceptin®). We have employed state-of-the-art
whole tumour clearing and imaging with confocal microscopy at
high spatial resolution in 3D to assess biodistribution, and large
volumetric imaging has revealed that the secreted therapeutic
diffuses significantly throughout the tumour leading to a therapeutic
effect and delayed tumour outgrowth. Moreover, the systemic
concentration of antibody is significantly reduced with viral
delivery, suggesting that paracrine delivery may be a promising
strategy for delivery of biologics with narrow therapeutic indices
Black carbon as an additional indicator of the adverse health effects of airborne particles compared with PM10 and PM2.5.
Current air quality standards for particulate matter (PM) use the PM mass concentration [PM with aerodynamic diameters ≤ 10 μm (PM(10)) or ≤ 2.5 μm (PM(2.5))] as a metric. It has been suggested that particles from combustion sources are more relevant to human health than are particles from other sources, but the impact of policies directed at reducing PM from combustion processes is usually relatively small when effects are estimated for a reduction in the total mass concentration
Cascades with Adjoint Matter: Adjoint Transitions
A large class of duality cascades based on quivers arising from non-isolated
singularities enjoy adjoint transitions - a phenomenon which occurs when the
gauge coupling of a node possessing adjoint matter is driven to strong coupling
in a manner resulting in a reduction of rank in the non-Abelian part of the
gauge group and a subsequent flow to weaker coupling. We describe adjoint
transitions in a simple family of cascades based on a Z2-orbifold of the
conifold using field theory. We show that they are dual to Higgsing and produce
varying numbers of U(1) factors, moduli, and monopoles in a manner which we
calculate. This realizes a large family of cascades which proceed through
Seiberg duality and Higgsing. We briefly describe the supergravity limit of our
analysis, as well as a prescription for treating more general theories. A
special role is played by N=2 SQCD. Our results suggest that additional light
fields are typically generated when UV completing certain constructions of
spontaneous supersymmetry breaking into cascades, potentially leading to
instabilities.Comment: 29 pages, a few typos fixed, improved discussion, added figure; now
there is 1 figur
Monopoles and Knots in Skyrme Theory
We show that the Skyrme theory actually is a theory of monopoles which allows
a new type of solitons, the topological knots made of monopole-anti-monopole
pair,which is different from the well-known skyrmions. Furthermore, we derive a
generalized Skyrme action from the Yang-Mills action of QCD, which we propose
to be an effective action of QCD in the infra-red limit. We discuss the
physical implications of our results.Comment: 4 pages. Phys. Rev. Lett. in pres
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