Improving Data Transmission Rate with Self Healing Activation Model for Intrusion Detection with Enhanced Quality of Service

Several types of attacks can easily compromise a Wireless Sensor Network (WSN). Although not all intrusions can be predicted, they may cause significant damage to the network and its nodes before being discovered. Due to its explosive growth and the infinite scope in terms of applications and processing brought about by 5G, WSN is becoming more and more deeply embedded in daily life. Security breaches, downed services, faulty hardware, and buggy software can all cripple these enormous systems. As a result, the platform becomes unmaintainable when there are a million or more interconnected devices. When it comes to network security, intrusion detection technology plays a crucial role, with its primary function being to constantly monitor the health of a network and, if any aberrant behavior is detected, to issue a timely warning to network administrators. The current network's availability and dependability are directly tied to the efficacy and timeliness of the Intrusion Detection System (IDS). An Intrusion-Tolerant system would incorporate self-healing mechanisms to restore compromised data. System attributes such as readiness for accurate service, supply identical and correct data, confidentiality, and availability are necessary for a system to merit trust. In this research, self-healing methods are considered that can detect intrusions and can remove with intellectual strategies that can make a system fully autonomous and fix any problems it encounters. In this study, a new architecture for an Intrusion Tolerant Self Healing Activation Model for Improved Data Transmission Rate (ITSHAM-IDTR) is proposed for accurate detection of intrusions and self repairing the network for better performance, which boosts the server's performance quality and enables it to mend itself without any intervention from the administrator. When compared to the existing paradigm, the proposed model performs in both self-healing and increased data transmission rates.

ANTIFUNGAL PROPERTIES OF SECONDARY METABOLITES OF AZADIRACHTA INDICA AND LAWSONIA INERMIS – AN IN SILICO STUDY

Objective: This study was aimed to inhibit the sulfite reductase using naturally obtained secondary metabolites of common plants Azadirachta indica and Lawsonia inermis.Methods: The active ingredients of neem and henna were selected and the.sdf files of these were downloaded from PubChem database. Converted the.sdf files to.pdb files with the help of OPENBABEL software which is prerequisite to dock. The three-dimensional structure was incurred from the template of homology of sulfite reductase using MODELLAR software version 9.0. Docking of sulfite reductase with the ligands was performed using iGEMDOCK and Autodock Vina softwares. The physicochemical, pharmacokinetic, drug-likeness, lead-likeness, and toxicological properties were obtained by SWISSADME and admetSAR online tools.Results: The active ingredients show an excellent affinity with the sulfite reductase which obtained was tabulated and the significant properties of a ligand were showing that these can be an investigational new drug entity.Conclusion: In this research, it can concluded that the secondary metabolites obtained from plants were inhibiting the induction of sulfite reductase thereby inhibiting Sulfite Assimilation Pathway leads to commove the amino acid metabolism of organism which shows unique in fungi

Processing and Characterization of Non-Speech Human Sounds -- A Step Towards Automatic Reporting of Respiratory Disease Symptoms

Non-speech human sounds, such as coughing and wheezing are common symptoms of many respiratory diseases, including chronic obstructive pulmonary disease (COPD), asthma, and COVID-19. Thereby, an objective reporting of these symptoms from smartphone microphones can help physicians to monitor and treat patients with different respiratory diseases. However, most often audio recordings from smartphones come with different types of background noises and other non-desired sounds, such as laughing, crying, and snoring. Therefore, it is crucial to first process the raw audio clips to extract desired events, such as coughing and wheezing. In our work, we use the Audacity desktop application to process raw audio clips obtained from various publicly available datasets, including COUGHVID and Environmental Sound Sense (ESC-50). While processing, we consider both visual and auditory inspection to extra the desired events. Next, we consider different data visualization techniques using the Audacity toolbox to analyze the processed audio signals and find the differences among various non-speech human sounds. These findings will help us to develop machine learning models and artificially intelligent systems that can be deployed on smartphones to detect various objective symptoms, such as coughs and wheezes, in real-time and can help physicians and healthcare providers to assess patient conditions remotely and promptly

Dendritic Cells Release HLA-B-Associated Transcript-3 Positive Exosomes to Regulate Natural Killer Function

NKp30, a natural cytotoxicity receptor expressed on NK cells is critically involved in direct cytotoxicity against various tumor cells and directs both maturation and selective killing of dendritic cells. Recently the intracellular protein BAT3, which is involved in DNA damage induced apoptosis, was identified as a ligand for NKp30. However, the mechanisms underlying the exposure of the intracellular ligand BAT3 to surface NKp30 and its role in NK-DC cross talk remained elusive. Electron microscopy and flow cytometry demonstrate that exosomes released from 293T cells and iDCs express BAT3 on the surface and are recognized by NKp30-Ig. Overexpression and depletion of BAT3 in 293T cells directly correlates with the exosomal expression level and the activation of NK cell-mediated cytokine release. Furthermore, the NKp30-mediated NK/DC cross talk resulting either in iDC killing or maturation was BAT3-dependent. Taken together this puts forward a new model for the activation of NK cells through intracellular signals that are released via exosomes from accessory cells. The manipulation of the exosomal regulation may offer a novel strategy to induce tumor immunity or inhibit autoimmune diseases caused by NK cell-activation

Evaluation of awareness about obesity among general public visiting the tertiary care hospital

Background: Obesity is one of the fastest growing threats of health and well-being for both developed and developing countries. The aim of the study was to evaluate the awareness about obesity among general public.Methods: After obtaining institutional ethics committee approval and written informed consent from the participants, anthropometric measures like height, weight, hip and waist circumference for computing body mass index and waist hip ratio were taken. Using portable bioelectric impedance analyzer body fat percentage was measured. A validated questionnaire including socio demographic details and questions evaluating the awareness about obesity were given to the participants.Results: Totally 100 participants were evaluated, of which majority being female. Mean height of the male and female participants was 164 and 152cm respectively. Similarly, mean weight was found to be 72 and 65 kg. Based on the body mass index only 19% participants were within normal range, remaining 81% were overweight and obese. Percent body fat and waist hip ratio was found to be increased in both sexes. Majority of the participants were aware that obesity is associated with health problems but most of them were unaware how it is measured and the dietary foods to be taken to reduce obesity. However 64% participants think that obesity can reduce the life expectancy of the individual.Conclusions: Majority of the participants were obese and overweight while awareness about preventive measures was still lacking. Hence health care personnel need to take greater effort to educate and inform people about the implications

Comparative Study of Iron Supplements in South Indian Antenatal Women with Iron Deficiency Anemia

BACKGROUND: Iron deficiency anemia is the most common nutritional disorder in the world. It is a major public health problem particularly among pregnant women with adverse effects on the mother and the new born. Iron supplementation is universally recommended to correct or prevent iron deficiency. AIMS & OBJECTIVE: The present study was conducted to compare the efficacy and tolerability of three oral iron preparations in anemic pregnant women of more than 14 weeks of gestation. MATERIALS AND METHODS: Randomized Control trial, done at Tagore Medical College and Hospital, Chennai. 60 antenatal women were selected; they were divided into three groups, 20 in each group. They were treated with Carbonyl iron, ferrous sulphate and ferrous fumarate. Hemoglobin estimation was done at 0 day, 30th and 60th day. Adverse effects were monitored. RESULTS: Data analysis showed an increase in haemoglobin levels in all three groups after the 30th day (p<0.05). Carbonyl iron showed highly significant increase (p<0.05) in the haemoglobin level as compared to the other two drugs at the end of the 60th day. CONCLUSION: Carbonyl iron is superior in efficacy when compared to ferrous sulphate and ferrous fumarate and is better tolerated. So carbonyl iron is safe in pregnancy and can be given as a supplement to treat iron deficiency anemia during pregnancy

Dynamin interacts with members of the sumoylation machinery

Dynamin is a GTP-binding protein whose oligomerization-dependent assembly around the necks of lipid vesicles mediates their scission from parent membranes. Dynamin is thus directly involved in the regulation of endocytosis. Sumoylation is a post-translational protein modification whereby the ubiquitin-like modifier Sumo is covalently attached to lysine residues on target proteins by a process requiring the concerted action of an activating enzyme (ubiquitin-activating enzyme), a conjugating enzyme (ubiquitin carrier protein), and a ligating enzyme (ubiquitin-protein is opeptide ligase). Here, we show that dynamin interacts with Sumo-1, Ubc9, and PIAS-1, all of which are members of the sumoylation machinery. Ubc9 and PIAS-1 are known ubiquitin carrier protein and ubiquitin-protein isopeptide ligase enzymes, respectively, for the process of sumoylation. We have identified the coiled-coil GTPase effector domain (GED) of dynamin as the site on dynamin that interacts with Sumo-1, Ubc9, and PIAS-1. Although we saw no evidence of covalent Sumo-1 attachment to dynamin, Sumo-1 and Ubc9 are shown here to inhibit the lipid-dependent oligomerization of dynamin. Expression of Sumo-1 and Ubc9 in mammalian cells down-regulated the dynamin-mediated endocytosis of transferrin, whereas dynamin-independent fluid-phase uptake was not affected. Furthermore, using high resolution NMR spectroscopy, we have identified amino acid residues on Sumo-1 that directly interact with the GED of dynamin. The results suggest that the GED of dynamin may serve as a scaffold that concentrates the sumoylation machinery in the vicinity of potential acceptor proteins

Analgesic activity of Cissus quadrangularis linn with Zingiber officinale rosc in male wistar rats

Background: The global scenario, human beings are using various forms of treatment for relief of pain; among them, medicinal plant products have gained popularity because of its wide range of use and less side effects.Methods: Adult Albino rats of either sex were selected and divided into 5 groups. The Eddy’s hot plate was used and maintained temperature (55±0.5ºC), the animals were placed on the hot plate and the time taken for paw licking or jumping was recorded and considered as nociceptive response. The reaction time was observed on 0, 30, 60, and 90 minute.Results: The hot plate reaction time in sec was collected in the intervals of 0, 30, 60 and 90 minutes in all groups. Reaction times as follows: group III (Cissus quadrangularis Linn.) were 2.18±0.04, 3.13±0.05**, 5.83±0.05**, 5.39±0.04**;  Group IV (Zingiber officinale Rosc.) were 2.12±0.03, 4.13±0.04**, 7.43±0.07**, 7.16±0.06**; Group V Cissus quadrangularis Linn+ Zingiber officinale Rosc.) were 2.21±0.75, 4.67±0.98**, 8.15±0.89**, 9.02±0.75**; Group II (Dexamethasone) were 2.14±0.05, 5.53±0.05**, 8.14±0.06**, 10.08±0.10** respectively, Results are presented as mean±SEM, (n=6), *p<0.01, **p<0.05 dunnet test used as compared to control.Conclusions: Present study reveals that, the combination treatment of Zingiber officinale Rosc. + Cissus quadrangularis Linn. has been shown significant analgesic effect. High analgesic effect was observed with combination therapy; the effect was shown same as standard drug dexamethasone

Decorrelation of user-defined function invocations in queries

Systems, methods, and computer-readable medium, are disclosed for transforming user-defined-function invocations in a query-based environment. A user-defined-function (UDF) and a query invoking the UDF are received. The UDF is parsed into a plurality of statements. A first expression tree corresponding to the UDF and a second expression tree corresponding the query are constructed, and merged using an operator to generate a transformed expression. The transformed expression is simplified, using transformation rules, if it is determined that is can be simplified

Compromised BRCA1-PALB2 interaction is associated with breast cancer risk.

The major breast cancer suppressor proteins BRCA1 and BRCA2 play essential roles in homologous recombination (HR)-mediated DNA repair, which is thought to be critical for tumor suppression. The two BRCA proteins are linked by a third tumor suppressor, PALB2, in the HR pathway. While truncating mutations in these genes are generally pathogenic, interpretation of missense variants remains a challenge. To date, patient-derived missense variants that disrupt PALB2 binding have been identified in BRCA1 and BRCA2; however, there has not been sufficient evidence to prove their pathogenicity in humans, and no variants in PALB2 that disrupt either its BRCA1 or BRCA2 binding have been reported. Here we report on the identification of a novel PALB2 variant, c.104T>C (p.L35P), that segregates in a family with a strong history of breast cancer. Functional analyses showed that L35P abrogates the PALB2-BRCA1 interaction and completely disables its abilities to promote HR and confer resistance to platinum salts and PARP inhibitors. Whole-exome sequencing of a breast cancer from a c.104T>C carrier revealed a second, somatic, truncating mutation affecting PALB2, and the tumor displays hallmark genomic features of tumors with BRCA mutations and HR defects, cementing the pathogenicity of L35P. Parallel analyses of other germline variants in the PALB2 N-terminal BRCA1-binding domain identified multiple variants that affect HR function to varying degrees, suggesting their possible contribution to cancer development. Our findings establish L35P as the first pathogenic missense mutation in PALB2 and directly demonstrate the requirement of the PALB2-BRCA1 interaction for breast cancer suppression