Safety, pharmacokinetics, and pharmacodynamics of escalating repeat doses of GSK249320 in patients with stroke.

Background and purposeRestorative therapies have the potential to improve function and reduce disability after stroke with a wide therapeutic window. The current study evaluated GSK249320, a monoclonal antibody that blocks the axon outgrowth inhibition molecule myelin-associated glycoprotein and also protects oligodendrocytes.MethodsPatients with mild-moderate stroke were randomized to intravenous GSK249320 (1, 5, or 15 mg/kg per infusion, in escalating cohorts of 8-9 subjects) versus placebo (n=17). Infusion 1 was 24 to 72 hours after stroke; infusion 2 was 9 ± 1 days later. The primary objective evaluated safety and tolerability, and the secondary objectives evaluated immunogenicity, pharmacokinetics, biomarkers, neurophysiology, and motor function.ResultsBaseline (n=42) characteristics were similar across treatment groups. No safety concerns were found based on adverse events, examination, vital signs, ECG, nerve conduction tests, brain imaging, motor function testing, and laboratory studies. Two of the 25 subjects dosed with GSK249320 developed transient antidrug antibodies after infusion 1. The pharmacokinetics profile was as expected for an IgG1 type monoclonal antibody. Serum levels of the biomarker S100β did not differ between groups. Global outcome measures were similar across groups. Modality-specific end points could be consistently measured in the first few days after stroke, and one of these, gait velocity, demonstrated a trend toward improvement with GSK249320 compared with placebo.ConclusionsGSK249320 was generally well tolerated. No major safety issues were identified in this first study of a monoclonal antibody to modulate the neurobiology of brain repair after stroke. Future studies might explore the efficacy of GSK249320 as a restorative therapy for stroke. Clinical Trial Registration- URL: http://www.clinicaltrials.gov. Unique Identifier: NCT00833989

First Administration of the Fc-Attenuated Anti-beta Amyloid Antibody GSK933776 to Patients with Mild Alzheimer's Disease: A Randomized, Placebo-Controlled Study

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The lived religion of Rome’s Roman Catholics

The Author reflects on a segment of the complex and multifaceted experience of Italian Catholicism provided by the analysis of the life stories of 29 Roman Catholics from Rome, gathered during the year 2016. Socialisation appears to be the fundamental mode of transmission of religious values, together with a personalization and re-elaboration of religious beliefs.La Autora reflexiona sobre un fragmento del complejo y multifacético catolicismo italiano a partir del análisis de 29 historias de vida de católicos romanos recogidas durante el 2016. La socialización aparece como el modo fundamental de transmisión de los valores religiosos, junto a una interiorización y reelaboración personal de las creencias religiosas.L'Autrice riflette su un frammento del complesso e poliedrico mondo del cattolicesimo italiano a partire dall’analisi di 29 interviste a cattolici romani, raccolte nel 2016. La socializzazione si conferma modalità fondamentale nella trasmissione dei valori religiosi accanto, però, ad una interiorizzazione e rielaborazione personale del credo religioso

Gli immigrati extracomunitari in Italia (1985-1995) e i diritti di cittadinanza: un'analisi di contenuto delle riviste italiane di sociologia.

Dottorato di ricerca in sociologia. 9 Ciclo. Coordinatore e tutore Franco LeonardiConsiglio Nazionale delle Ricerche - Biblioteca Centrale - P.le Aldo Moro, 7, Rome; Biblioteca Nazionale Centrale - P.za Cavalleggeri, 1, Florence / CNR - Consiglio Nazionale delle RichercheSIGLEITItal

Orfeo tra gli animali nella cripta della Basilica di Aquileia. Fortuna iconografica del mitico cantore tra antichità e medioevo

Il presente contributo propone una riflessione sull'enigmatico cantore con la lira tra gli animali dipinto nel velario medievale della cripta della Basilica di Aquileia. La critica storico-artistica ha delineato due ipotesi interpretative divergenti, volte a identificare il soggetto come il pagano Orfeo o Davide salmista. Nella prospettiva di fornire una corretta lettura dell'immagine, si vuole indagare la fortuna iconografica del cantore citaredo nel repertorio antico e medievale

Space and time: dimensions of captive apes well-being

SPACE AND TIME: DIMENSIONS OF CAPTIVE APES WELL-BEING Monica Carosi1, Barbara Simeoni1, Cristina Sagnotti2, Pietro Ciaccia2, Maria Ricotta5, Ilaria Orlando6 1 Roma Tre University, 2 Safari Ravenna, 3 University of Florence, 4 Zoosafari di Fasano In captivity space and time represent two main axes around which the quality of life and variability of social interactions may find the proper amount of degrees of freedom to express. Environmental enrichment, arising from a proper space/time interplay, should aim at allowing an animal behavioral choice, therefore increasing sense of control, which in turn may lower stress and grant well-being. These are the stories of four chimpanzees (Pan troglodytes verus) who have been rescued from an inhibited and human-like life, and the last gorilla (Gorilla gorilla) left in Italy. In collaboration with the hosting safaris (Safari Ravenna and Zoosafari di Fasano, Italy) we provided them enriched space and time. We carried out a strictly planned environmental enrichment program and studied ape behavioral response over a control and an enrichment period. Enrichment included varied substrates for locomotion; an assorted diet; diversified food provisioning and unpredictable schedule; chances to freely express agonistic behaviors (chimps), and interaction-with-operator sessions (gorilla). Behavioral categories analyzed were displacement activities, abnormal behaviors (including stereotypies), prosocial behavior, agonism and activity budget (AB), with air temperature, amounts of public and noise as covariates. Although high chimpanzee inter-individual variability and differences in housing and social conditions between species, two main common outcomes of enrichment were: changes in AB (mainly locomotion), and the decrease of stress as measured by both displacement activities and abnormal behaviors. Further success for the gorilla was the healing of a long lasting self-induced wound